erythrocytosis

Understanding Polycythemia

Hot off the press! 25th Annual Fall Scientific Meeting of SMSNA! Grapevine, Texas! Great presentation! 1:29:40-1:43:30 Conclusions

* Venesection is not recommended except for clonal erythrocytosis, due to its potential pro-thrombotic effects. * Repeated venesection can lead to decreased tissue oxygen pressure (pO2) and depletion of iron stores; factors which activate biological pathways that may paradoxically promote the...

https://www.physiciansweekly.com/frequency-of-testosterone-induced-erythrocytosis-in-trt/ The following is a summary of “Prevalence and predictive factors of testosterone-induced erythrocytosis: a retrospective single center study,” published in the January 2025 issue of Endocrinology by...

FIGURE 2 Management of erythrocytosis (Source: adapted from BSH guidelines 2019).6 Abstract An absolute erythrocytosis is present when the red cell mass is greater than 125% of the predicted. This is suspected when the hemoglobin or hematocrit is above the normal range. An erythrocytosis...

* When there is a medical history of cardiovascular disease a lower cut-off value for phlebotomy could be applicable (e.g. 0.52) but this is case specific and should be considered on an individual level. Dutch Society for Endocrinology...

https://ec.bioscientifica.com/view/journals/ec/aop/ec-24-0283/ec-24-0283.xml Therapeutic Phlebotomy: A Double-Edged Sword? Current Guidelines: "Several endocrine organizations mention therapeutic phlebotomy as a means of treating TTh–induced erythrocytosis, commonly with a hematocrit cutoff...

https://emedicine.medscape.com/article/205039-overview?form=fpf Practice Essentials In secondary polycythemia, the number of red blood cells (RBCs) is increased as a result of an underlying condition. Secondary polycythemia would more accurately be called secondary erythrocytosis or...

https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgae434/7697829?redirectedFrom=fulltext&login=false Conclusions We conclude that hypogonadal men have reduced erythrocyte lifespan and acute androgen-induced increase in circulating erythrocyte lifespan may contribute...

ABSTRACT Objective Elevated hematocrit (Hct) can result in increased risk of major adverse cardiac events(MACE) in men receiving testosterone therapy (TTh). However, the impact of the magnitude of the change in Hct from baseline after starting TTh has never been assessed. Methods To assess...

https://auanews.net/issues/articles/2024/february-extra-2024/obstructive-sleep-apnea-and-its-impact-on-mens-health Obstructive sleep apnea (OSA) is a progressively prevalent condition characterized by recurrent episodes of partial (hypopnea) or total (apnea) upper airway collapse during sleep...

I am currently on Natesto and while it works it is ultimately insufficient w/ a peak testosterone only around 400. I have covered studies on gels and pill options and it appears that pills are a very good approach with the softest effect on hematocrit. There is some debate in the literature and...

Shane M. Kelleher, *InfiniT Men’s Health Clinic, Burleson, TX76028, USA Abstract The goal of this study was to determine how to minimize the secondary polycythemia effect observed in patients on testosterone replacement therapy (TRT). Patient hemoglobin, estradiol (E2), and total...

https://academic.oup.com/jsm/article/21/Supplement_1/qdae001.084/7600775 Abstract Introduction Sustained treatment with elevated levels of exogenous testosterone (T) has been linked to various adverse events, particularly concerning cardiovascular risks. However, there is currently a lack of...

Abstract Background A growing prevalence of male hypogonadism has led to increased interest in the most common adverse event, erythrocytosis. Defined by hematocrit (HCT) > 49-51%, the incidence varies depending on the testosterone formulation.3 The formulations with the lowest risk of...

Men’s Sexual Health: why it matters, what can go wrong, and how to fix it Mohit Khera interviewed by Peter Attia MD Mohit Khera, M.D., M.B.A., M.P.H., Professor, is the Director of the Laboratory for Andrology Research at McNair Medical Institute, Baylor College of Medicine. He is also the...

32:10-44:58

Testosterone Therapy and Men’s Health – Demystifying the Hype with Science to Provide Cutting-Edge Treatment for Your Patients (2021) Summary 25:10-43:34 (Endocrine Society 2018 Guidelines) https://t4leducation.com/video/other-risks-with-testosterone-therapy-and-how-to-manage-them/

Prevalence of secondary erythrocytosis in men receiving testosterone therapy: A matched cohort analysis of intranasal gel, injections, and pellets (2023) Rohit Reddy*, Parris Diaz*, Ruben Blachman-Braun, Justin Loloi, Farah Rahman, Jesse Ory, Alexandra Dullea, Isaac Zucker, Daniel C. Gonzalez...

Living at higher elevation with higher hematocrit may decrease cardiovascular risk! https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525493/...

Management of Erythrocytosis in Men Receiving Testosterone Therapy: Clinical Consultation Guide (2022) Pranjal Agrawal, Sajya M. Singh, Taylor Kohn 1. Introduction Testosterone deficiency, previously known as male hypogonadism, affects approximately 25% of all men, with a prevalence that...

I just wanted to get a feel for everyone's different level and what they are comfortable with as I've noticed the difference is big. I would like my HGB to stay in the 17's and HCT to be very low 50's, but I'm seeing that even 4mg daily is too much. 3 weeks ago my RBC was 5.87, HGB 17.7 and...

Erythrocytosis in Subcutaneous Testosterone Replacement Therapy Author links open overlay panel (2022) TWilliamson, JTrussler, AMcCullough Introduction Intramuscular (IM) testosterone replacement therapy (TRT) is commonly administered to treat symptomatic male hypogonadism and can result in...

Testosterone therapy and secondary erythrocytosis (2021) Joshua White, Francis Petrella, and Jesse Ory Secondary erythrocytosis is one of the most common adverse events associated with testosterone therapy (TT). Upon encountering this, clinicians will often either adjust TT dosing, stop...

This is my experience after studying and dealing with high hematocrit due to TRT. It worked for me maybe it might work for others. Me like many users here had the problem of high hematocrit and the need for frequent blood donations and dealing with low ferritin. I tried everything and nothing...

I have been using testosterone cyp injections for the last 6 years to treat low T levels. I inject 0.66 ml once per week. I recently had to get a new Dr. because my regular GP retired. I live on the Big Island, where it is very hard to find good doctors. Long story short, my new Doc ordered lots...

So my understanding is that if it is TRT raising your hematocrit levels, this is erythrocytosis not Polycythemia (Poly). Poly can cause a stroke but can erytho? I should be watching platelet counts and not hematocrit/hemoglobin?.. my platelets have not gone up in the 4 years on TRT That...