Lh/fsh

In this episode of Better Edge, Robert Brannigan, MD, president of the American Society for Reproductive Medicine (ASRM), discusses key updates from ASRM’s 2026 committee opinion on fertility preservation. Dr. Brannigan outlines what urologists should know about early identification, rapid...

Curated By Nelson Vergel | ExcelMale.com | Updated June 2026 If you've been on TRT for a while and still deal with flat libido or low motivation - even with testosterone in a solid range - there may be more happening than your T levels alone can explain. One underappreciated piece of that...

* We evaluated, for the first time in humans, whether chronic subcutaneous (SC) administration of kisspeptin-10 (KP10) can sustain gonadotropin secretion without desensitization. * This study provides the first evidence that chronic SC KP-10 administration can sustain gonadotropin secretion in...

Join us for a live AMA on male fertility and sperm health! Urologist Dr. Andrew Sun (Urology Partners of North Texas) and reproductive endocrinologist Dr. Noorhasan (CCRM DFW) are teaming up to answer your questions — no topic off limits. From semen analysis and lifestyle factors to...

Justin Dubin, M.D. Urologist Director of Men’s Sexual Health Baptist Health Miami Cancer Institute

15:01 - Diagnosis, Assessment and Evaluation Male factor infertility accounts for nearly half of all infertility cases, yet male evaluation is often delayed or overlooked. In this episode of BackTable Urology, Dr. Robert Brannigan joins guest host Dr. Catherine Nam to unpack the 2024...

* In male infants, luteinizing hormone (LH) and testosterone during minipuberty are present at levels similar to those in adults but subsequently become undetectable. This phenomenon was shown in infant boys more than 50 years ago. https://www.nejm.org/doi/full/10.1056/NEJMra2305989

Abstract INTRODUCTION AND OBJECTIVES: Clomiphene citrate has been used off-label to treat male hypogonadism by stimulating endogenous gonadotropin secretion. Enclomiphene, the trans-isomer of clomiphene, is increasingly prescribed, but comparative data remain limited. We aimed to assess whether...

* Randomized trials in obese hypogonadal men showed benefits including increased muscle mass, reduced fat, higher HDL, improved erectile function, and elevated TT. Older age (>55 years) was linked to reduced androgenic response. In late-onset hypogonadism, CC discontinuation led to relapse...

* Within the arcuate nucleus, a specialized subset of kisspeptin neurons, known as KNDy (Kisspeptin/Neurokinin B/Dynorphin) cells, functions as a “pulse generator,” coordinating rhythmic bursts of activity that drive the pulsatile release of GnRH [3, 4]. * Three healthy adult men received a...

https://drarthurburnett.com/press-releases/ Infertility is not just a women’s issue, male fertility plays a role in up to 50% of cases.In this episode of HealthYouniversity, renowned urologist and men’s health expert Arthur Burnett breaks down what’s really happening with male...

* Fertility preservation remains an important consideration in the management of hypogonadal men. While exogenous testosterone therapy effectively alleviates symptoms, it suppresses the HPG axis and impairs spermatogenesis. Alternative therapeutic strategies—including short- acting formulations...

In this video, Dr. Jonathan Clavell—board-certified urologist and men’s health specialist in Houston, Texas—breaks down exactly how testosterone works, where it comes from, how it’s regulated, and how we test and treat it. Learn about: • The connection between your brain and testicles that...

https://pmc.ncbi.nlm.nih.gov/articles/PMC12544852/pdf/bvaf149.2003.pdf Author Block: Ashley Kieran Clift, Jeff Foster, David R. Huang. Manual (Menwell Ltd), London, United Kingdom. Disclosure Block: A.K. Clift: I am an employee of Manual (Menwell Ltd), a healthcare provider that provides...

* Gonadotropin treatment has dual roles, including hCG effects on Leydig cell luteinizing hormone (LH) receptors to increase testosterone production and FSH causes proliferative effects on Sertoli cells to support spermatogenesis within the seminiferous tubules [5]. * Treatment‐related...

* Data from 166 men seeking first medical help for primary MFI with low sperm counts who were prescribed CC 50 mg QD, with a second semen analysis available at follow-up after treatment initiation, were analyzed * CC effectively increases both sperm concentration and total testosterone levels...

* In men with TD, lower LH levels and higher TT levels were a predictors of CC response. Clinicians can incorporate this into their treatment discussions with patients with TD. https://academic.oup.com/jsm/article/22/Supplement_4/qdaf320.156/8375133 PREDICTORS OF CLOMIPHENE CITRATE...

* Samples of venous blood were obtained from 22 healthy adult males age 19-26 before and after the im injection of testosterone in aqueous suspension (Oreton©). * The administration of the 12.5 and 25.0 mg of testosterone daily was reflected by markedly higher levels of serum testosterone...

ABSTRACT Clomiphene Citrate (CC), a selective estrogen receptor modulator, represents a valuable therapeutic option for addressing male hypogonadism and infertility. This article reviews practical approaches to CC prescription, emphasizing its use both as monotherapy and in combination with...

Hot off the press, Nelson's domain is where it's at! *30 patients with TRT induced infertility were treated with doses of HCG ranging from 500 to 3000 IU every MWF. Nine patients were lost to follow up. Median length of follow-up was 4 months (1-10 month range). Average length of TRT use was...

Abstract Kisspeptin-10 is a peptide hormone capable of increasing circulating follicle stimulating hormone, luteinizing hormone and testosterone levels in humans. Clinically, these effects suggest its use as a treatment for infertility. However, its testosterone-increasing effect indicates...

Are there significant difference between Clomiphene citrate and Enclomiphene citrate to warrant using one over the other? I will explain some of the Pros and Cons of each and then discuss our outcome experiences and side-effects in over 800+ clients. I address our 2014, three-year clinical...

After nearly 15 years of providing clomiphene citrate as an initial alternative approach to testosterone replacement therapy for hypogonadism, I am releasing the article "The Application of Clomiphene citrate in the Management of Hypogonadism Secondary to Concussive and Subconcussive Brain...

INTRODUCTION AND OBJECTIVE The predictive metrics for assessing fertility outcomes following clomiphene citrate (CC) treatments are understudied. Our objective was to delineate the pretreatment sex hormones that exhibit the strongest correlation withsemen parameter improvements in CC-treated...

The pharmacological regimen increased E2 levels for more than 24 hours, affecting the HPG axis, LH, FSH, P4, TST, DHT, SHBG, and IGF-1. While E2 had similar effects to longer-term treatments, SHBG levels did not increase. TST and DHT changes could confound the effects of E2. These hormones have...

Male infertility and gonadotropin treatment: What can we learn from real-world data? (2022) Sandro C. Esteves, Arnold P.P. Achermann, Manuela Simoni, Daniele Santi, Livio Casarini Abstract Gonadotropin therapy to treat specific male infertility disorders associated with hypogonadotropic...

Reproductive Hormone Secretion is Increased by Intranasal Kisspeptin in Humans (2022) Edouard G Mills, MBChB MRCP, Magda Swedrowska, Ph.D., Layla Thurston, MRCP, Maria Phylactou, MRCP Ph.D., Bijal Patel, MRCP, Lisa Yang, MRCP Ph.D., Sophie A Clarke, MRCP Ph.D., Beatrice Muzi, MSc, Emma...