metabolism

Curated By Nelson Vergel | ExcelMale.com | Updated June 2026 If you've been on TRT for a while and still deal with flat libido or low motivation - even with testosterone in a solid range - there may be more happening than your T levels alone can explain. One underappreciated piece of that...

* Estrogen signaling: Estradiol binds nuclear and membrane receptors to regulate gene expression and mitochondrial function; it enhances insulin sensitivity and browning in fat cells, with receptors like ER-alpha feminizing fat distribution. The biology of fat tissue, estrogen's role in...

* The discovery of kisspeptin neurons in the early part of this century revolutionized our understanding of reproductive regulation. These neurons project to and control GnRH neuronal excitability. More recently, arcuate kisspeptin neurons (KNDy) have been identified as the command neurons...

I’ve covered this issue in many posts, but I thought it would be helpful to put more information in one thread and expand on the topic. TL;DR: Under TRT, free testosterone is proportional to the dose rate and inversely proportional to the metabolic clearance rate. The liver accounts for most of...

Objectives Hyperprolactinemia has been proven to induce hypogonadism and metabolic derangements in both genders ,while the consequences of prolactin (PRL) deficiency have been poorly investigated. The aim of the study is to systematically review and analyze data from clinical studies focusing...

I really enjoy Lustig. a lot of good data. you need to watch the whole thing.

Kisspeptin (KP) and neurokinin B (NKB) regulate the reproductive endocrine axis by influencing GnRH activity and secretion. Inactivating variants in KP or NKB signaling can lead to hypogonadotropic hypogonadism and pubertal development failure. KP and NKB offer potential therapeutic applications...

Historically, been on cypionate for years. New NP (who I recently decided to dump due to perceived incompetence and carelessness) just switched me to enanthate. The relevant info here is that I metabolize meds super fast. Doctors never believe me unless they see it (in hospital, surgical...

CHANGES IN METABOLIC PARAMETERS AND BONE MARKERS WITH ORAL VERSUS TOPICAL TESTOSTERONE (2022) Fiona Yuen, Ronald S Swerdloff, Robert Dudley, and Christina Wang The Lundquist Institute at Harbor-UCLA Medical Center, Torrance, CA; Clarus Therapeutics, Northbrook, IL Background: Oral testosterone...