Neurosteroids

DEEP DIVE: Strategies to Increase Allopregnanolone A Comprehensive Review for Mental Health Support 1. What is Allopregnanolone? Allopregnanolone (ALLO) is a neurosteroid synthesized from progesterone that acts as a potent positive allosteric modulator of GABA-A receptors. [1,2] Its potency at...

I noticed today my testicles are moving again just as they did in 2019 after stopping TRT and earlier in life. My testicles are constantly moving, twisting and rotating around each other. I do have some testicular pain on and off. I'm starting to wonder if this was my original medical issue...

Testosterone deficiency can be a devastating condition associated with adverse emotional and physical conditions, but it should not be the first answer to the problem. Understanding that trauma induced neuroinflammation and medication such as Ibuprofen can cause testosterone deficiency. A...

Abstract Rates of alcohol use disorder (AUD) are increasing in men and women and there are high rates of concurrent posttraumatic stress disorder (PTSD) and AUD. AUD and PTSD synergistically increase symptomatology and negatively affect treatment outcomes; however, there are very limited...

Has anybody been able to overcome brain fog from ptsd and depression? If so how did you do it? What helped the most? How did you get your energy back and ability to focus? Thank you

Allopregnanolone: Regenerative therapeutic to restore neurological health (2023) Gerson D. Hernandez, Roberta D. Brinton ABSTRACT Chronic stress has been proposed as a driver of altered brain structure and function, including the pathogenesis of neurodegenerative diseases, and a driver of...

PPD: Postpartum depression MDD: Major Depressive Disorder This webcast features presentations that examine the diverse pathophysiologic mechanisms that may contribute to MDD and PPD and the resultant implications for therapeutic targeting, including the GABAergic signaling pathway.