spermatogenesis

* Fertility preservation remains an important consideration in the management of hypogonadal men. While exogenous testosterone therapy effectively alleviates symptoms, it suppresses the HPG axis and impairs spermatogenesis. Alternative therapeutic strategies—including short- acting formulations...

* To our knowledge, this is the first report demonstrating alterations in spermatogenesis as intratesticular morphological changes, specifically enlargement of seminiferous tubules, by US. Ultrasonographic Seminiferous Tubule Changes Track Gonadotropin Response in Azoospermia The provided text...

* Human chorionic gonadotropin (hCG) therapy can be co-administered with TTh to maintain spermatogenesis, testicular size, or libido, but no study has assessed associated 17-OHP levels in these men on concurrent TTh and hCG therapy. levels in men on TTh. * In our practice, hCG 1500 IU...

* In HH males, the best results in terms of sperm production are achieved with the co-administration of human chorionic gonadotropin (hCG) and FSH [2, 4]. * Intratesticular testosterone (ITT) binds intracellular androgen receptors located on Sertoli cells, stimulating the secretion of...

This systematic review aimed to assess the most effective treatment approaches for male infertility caused by the abuse of Anabolic Androgenic Steroids (AAS). The review followed the PRISMA guidelines and included studies that compared various protocols for restoring spermatogenesis in...

Human in vitro spermatogenesis as a regenerative therapy — where do we stand? (2023) Meghan Robinson, Sydney Sparanese, Luke Witherspoon & Ryan Flannigan Abstract Spermatogenesis involves precise temporal and spatial gene expression and cell signaling to reach a coordinated balance between...

Hi all, Is it possible that HCG run along with TRT could impact sperm motility? I had a decent count when running both, but motility was very low, could FSH be needed in sperm production to maintain adequate motility or is it something different? Currently off Test and running clomid to restore...

https://www.sciencedirect.com/book/9780128216767/human-gonadotropins#book-description Function of follicle-stimulating hormone and the follicle-stimulating hormone receptor (2022) Grace Whiteley, Peter G. Lindner, Kathryn Schmiech, and Micah Hill Follicle-stimulating hormone (FSH)...

Hypogonadism is a deficiency in one of the testes’ two major functions: (a) testosterone secretion (endocrine function) and (b) spermatogenesis (reproductive function). The two types are known as primary (hypergonadotrophic) hypogonadism (testis failure) and secondary (hypogonadotrophic)...

https://www.clinicaltrials.gov/ct2/show/study/NCT05381831 Study Description Brief Summary: This is a prospective, non-blinded study of hypogonadal men with a history of testosterone therapy who became azoospermic or severely oligospermic and wish to avoid symptoms of hypogonadism during...

Fertility in men with Klinefelter’s syndrome (2022) Ingrid Plotton, Lucie Renault, Marion Lapoirie, Damien Sanlaville, René Ecochard, Sandrine Giscard d’Estaing, Beatrice Cuzin, Frederique Dijoud, Bruno Salle, Hervé Lejeune Abstract Patients with Klinefelter syndrome (KS), defined by a 47...

The study provides strong evidence that once-a-week gonadotropin therapy (HCG + HMG) is a viable and effective alternative to the traditional twice-a-week regimen for inducing spermatogenesis in male HH patients. Its comparable efficacy across key outcomes (sperm production, time to appearance...

Understanding and managing the suppression of spermatogenesis caused by testosterone replacement therapy (TRT) and anabolic–androgenic steroids (AAS) (2022) Ankit Desai , Musaab Yassin, Axel Cayetano, Tharu Tharakan, Channa N. Jayasena and Suks Minhas Abstract The use of testosterone...

Suppression of Spermatogenesis by Exogenous Testosterone (2021) Ferdinando Fusco, Paolo Verze, Marco Capece and Luigi Napolitano Abstract Sperm production starts from puberty in the seminiferous tubules providing testosterone production by the Leydig cells that take place in the interstice of...

This would be after the normal 4-6 week hcg run after coming off testosterone, so would doing another run of HCG 12-16 weeks after stopping testosterone, slow the recovery process ?? I know it can take 9+months to fully recover