tirzepatide

  1. Nelson Vergel

    GLP-1 Medications: Preventing Muscle Loss During Treatment & Weight Regain After Discontinuation

    GLP-1 Therapy Clinical Guide Preventing Muscle Loss During Treatment & Weight Regain After Discontinuation Evidence-Based Strategies with Annotated References Executive Summary GLP-1 receptor agonists (semaglutide, tirzepatide, liraglutide) have revolutionized obesity treatment, producing weight...
  2. O

    Trouble Finishing (GLP-1 & TRT protocol discussion)

    Newly joined member here but have been lurking for 6mo learning and absorbing as much as I can here. Appreciate what an incredible resource this site is and the members contributing. I fell into the trap of eating poorly, drinking often, and spiraling my weight out of control in the last few...
  3. Nelson Vergel

    Optimizing Fat Loss and Muscle Preservation: Tirzepatide + Oxandrolone + TRT + Protein & Exercise

    This article outlines a comprehensive strategy for optimizing fat loss and muscle preservation, primarily discussed within the context of an online forum dedicated to men's health, ExcelMale.com. The core of the strategy involves a multi-faceted approach combining specific pharmacotherapies...
  4. Nelson Vergel

    Website that compares prices of GLP-1 weight loss medications (Ozempic, Mounjaro, Compounded)

    Sabina Hemmi was taking a compounded obesity medicine, when the price jumped from $550 a month to $875 a month. "I was like, 'What the hell?' " She started shopping around, but found it confusing. Most telehealth sites offering compounded obesity drugs didn't list prices and wouldn't reveal...
  5. Nelson Vergel

    GLP-1 Medications (Semaglutide, etc.) Decrease Sex Drive

    Study at a Glance Title: “Assessing the Impact of GLP-1 Receptor Agonists on Sexual Desire: A Qualitative Review” Authors: H. Quaile & R. Horwitz Journal: Journal of Sexual Medicine — published 1 April 2025 Why This Matters Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) such as...
  6. Nelson Vergel

    Empower Pharmacy CEO Shaun Noorian Challenges Big Pharma Over GLP-1 Drug Access and Pricing

    Everyone is talking about GLP-1s. As these so-called "miracle drugs" for weight loss exploded in popularity, shortages quickly followed. That’s when compounding pharmacies stepped in, offering lower-cost, customizable versions of these medications. But are patients really getting the same...
  7. Pacman

    Tirzepatide: additives, alternative sources, and how to deal with the ban?

    I just found out about the whole ban on compounded tirzepatide (I been living under a rock apparently). My provider presents these options to me now: Empower Pharmacy (Tirzepatide/Niacinamide) Strive (Tirzepatide/Glycine/B12) Southend Pharmacy (Tirzepatide/B6) Red Rock (Tirzepatide/Glycine) I...
  8. madman

    The Golden Era of GLP-1 Drugs

    Chapters: 0:00—Introduction to GLP-1 Drugs 08:48—Obesity as a Major Health Concern 11:52—Diabetes: The Original Indication for GLP-1 15:26—Cardiovascular Implications of GLP-1 20:16—Kidney Health and GLP-1 Mechanisms 24:02—Exploring GLP-1 Effects on Mental Health 29:27—Challenges and Side...
  9. Nelson Vergel

    Tirzepatide vs Semaglutide: Pros and Cons

    Tirzepatide and semaglutide are both injectable medications used for weight loss and type 2 diabetes management, but they differ in their mechanisms of action and effectiveness. Here's a comparison of the two drugs: Mechanism of Action Tirzepatide: Dual glucose-dependent insulinotropic...
  10. B

    DPP-4 inhibitors - blocking the breakdown of GLP-1

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7011940/?fbclid=IwAR2tVliRNZld3ui2Kp70UeUrWFWsRaG5vphx8EF13fdB4aUn-vBc0v1aEKY_aem_AbqXSwyVpOvYCcYGlesCJW4UniV_Gzu02SPO3aX-qfs_8EF0ogIva-jCpe-_fAOuAmA#:~:text=In%20conclusion%2C%2024%2Dweek%20treatment,induced%20improvement%20of%20glycemic%20control
  11. madman

    Pros & Cons of GLP-1 Weight Loss Drugs

    In this video, Mark Scholz and Mark Moyad discuss the pros and cons of weight loss drugs, particularly those that have shown significant weight loss results in patients. They emphasize that these drugs are not for cosmetic purposes, but for individuals with severe weight-related health issues...
  12. madman

    Tirzepatide Bests Semaglutide For A1c, Weight Loss

    https://www.hcplive.com/view/tirzepatide-bests-semaglutide-for-a1c-weight-loss-in-indirect-comparison-of-clinical-trial-data A network meta-analysis suggests tirzepatide may be more effective than semaglutide in reducing HbA1c and body weight in type 2 diabetes but may increase gastrointestinal...
  13. M

    Lean mass loss on GLP-1 receptor agonists: a downside of the “miracle drugs”

    Has anyone done a DEXA scan before and during use of any GLP-1 agonists (semaglutide, tizepatide) to assess body composition? In Peter Attia's recent blog, he eludes to the fact the GLP-1 agonists can cause loss of lean mass (in addition to fat loss), of particular concern in non-obese persons...
  14. madman

    Anti-Obesity Medications and Investigational Agents

    Anti-Obesity Medications and Investigational Agents: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2022 Harold E. Bays, Angela Fitch, Sandra Christensen, Karli Burridge, Justin Tondt ABSTRACT Background: This “Anti-Obesity Medications and Investigational Agents: An...
  15. madman

    Tirzepatide - First in a new class of diabetes medication (Part 2)

    Tirzepatide is a new class of medication for t2d that activates GIP and glp1 receptors. Endocrinologist Dr. Thomas Blevins (MD, FACE) from Texas Diabetes and Endocrinology, Austin, TX, presents data and practical information for clinicians.
  16. madman

    Tirzepatide - First in a new class of diabetes medication (Part 1)

    Tirzepatide is a new class of medication for t2d that activates GIP and glp1 receptors. Endocrinologist Dr. Thomas Blevins (MD, FACE) from Texas Diabetes and Endocrinology, Austin, TX, presents data and practical information for clinicians.
  17. madman

    Once-Weekly Tirzepatide for Obesity

    Here are the key points from the video titled "Once-Weekly Tirzepatide for Obesity | NEJM": Study Objective: The trial investigated the effectiveness of the type 2 diabetes drug, tirzepatide, in inducing weight reduction in adults with obesity or overweight plus a weight-related complication...
  18. madman

    Tirzepatide Once Weekly for the Treatment of Obesity

    Tirzepatide Once Weekly for the Treatment of Obesity (2022) Ania M. Jastreboff, M.D., Ph.D., Louis J. Aronne, M.D., Nadia N. Ahmad, M.D., M.P.H., Sean Wharton, M.D., Pharm.D., Lisa Connery, M.D., Breno Alves, M.D., Arihiro Kiyosue, M.D., Ph.D., Shuyu Zhang, M.S., Bing Liu, Ph.D., Mathijs C...
  19. madman

    Tirzepatide: A New Treatment for Diabetes

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