cortisol

  1. B

    New to TRT

    Hi all, I am 9 weeks in. Any ideas as to why my cortisol crashed 50% and T4 dove as well? I must say that I have pretty lazy with the pregnolone... could that be it? thanks, Mike 1. Testosterone cypionate 200mg/mL, 0.3mL twice weekly, 2. Anastrozole 0.5mg/mL mixed in with the testosterone...
  2. D

    How does Trt affect cortisol, and sexual function?

    How does TRT affect cortisol? I had my AM cortisol checked last Thursday and it was a little high: 23.5 mcg/dL (4.0-22.0 lab range). Should I be concerned or is this basically normal? I've had trouble getting clear answers about what constitutes a high AM cortisol level and what I can do about...
  3. A

    Estradiol stimulates cortisol production

    I was looking for something else, when I came across this study: Estradiol stimulates cortisol production by adrenal cells in estrogen-dependent primary adrenocortical nodular dysplasia. - PubMed - NCBI It's an old study and it has been performed on a single patient with ACTH-independent...
  4. DragonBits

    What are good optional blood / metabolic tests to take?

    I was looking at tests that are beyond the one's typically needed for TRT. I already get the the typical TRT tests that are recommended by Defy and most doctors. I do tend to have trouble staying asleep and in keeping my LDL chol low, but I am looking for health wellness in test in general...
  5. M

    Testosterone propionate for TRT

    Hey guys, I just want to report my experience with testosterone Propionate. I would love to hear anyone else’s experience. I had been on TRT for two years. I was on Test Cyp for 2 years. I felt better on than of first it but I would get flu like symptoms with it, fatigue, no recovery for...
  6. lemonflavor

    Case Challenge: Chronic Opioid Use Causing Adrenal Insufficiency

    Case Challenge: Chronic Opioid Use Causing Adrenal Insufficiency Sickle cell anemia patient develops opioid-induced endocrinopathy while on chronic opioid therapy. I found this interesting even without the opioid component. Lab numbers are included in the article. She was either at the low end...
  7. M

    Nandrolone, oxandrolone effect on HPA

    Hey guys, I’m curious if anyone knows that anabolics such as oxandrolone and nandrolone effect on cortisol is? I know that oxandrolone disturbs signaling between AR and GR thus decreasing cortisol from binding to receptors but I wonder if it affects mostly muscle tissue uptake of cortisol...
  8. lemonflavor

    I found some old cortisol lab results - thoughts?

    I'm going to be getting ACTH and the 4x a day saliva cortisol test done ASAP. I really hope this might shed light on some problems, and hopefully help, but we'll see. I don't want to post a whole story, but I've dealt with depression, fatigue, anxiety, etc. most of my life and recently feel...
  9. Will Brink

    Lower Cortisol/reduce stress with whey?

    Whey protein never fails to amaze and surprise me for its long list of potential benefits. One unexpected benefit of whey may be that of a mood elevator and antidepressant. This effect of whey is actually not a new finding. I wrote about that in an article on how whey may assist weight loss in...
  10. Nelson Vergel

    The effects of six-day SSRI administration on diurnal cortisol secretion in healthy volunteers

    Send to Psychopharmacology (Berl). 2018 Dec;235(12):3415-3422. doi: 10.1007/s00213-018-5050-1. Epub 2018 Oct 3. The effects of six-day SSRI administration on diurnal cortisol secretion in healthy volunteers Ronaldson A1, Carvalho LA2, Kostich K3, Lazzarino AI3, Urbanova L3, Steptoe A3...
  11. N

    22y/o - sudden weight gain on trt

    Wondering if this is a cortisol issue 22 yrs old, TRT + HCG for about 7 months Background: suffered from all symptoms of low test except for issues with weight. I was tested 6 months prior to starting trt at serum 490ng/dL (low for my age but not devastating) tested again a month before...
  12. V

    Should I bother with figuring out the DHEA Pregnenolone Cortisol puzzle with Test should I choose to use a PED?

    Hello everyone. Recently, I have been trying to figure out why despite taking 200 mg/ml test in 1 ML dosages split twice a week, I still feel like shit a lot of times. On top of regular psychological issues, Im trying to figure out what I could be doing to get to the fabled golden zone that...
  13. A

    Cortisol issues with HCG ?

    We know the chain is HCG-->pregnenolone--->progesterone---->17-hydroxyprogesterone, which converts to cortisol. Is this why it is common to have issues with HCG? Seems people on the forum are moving away from HCG.
  14. C

    33 yo w/ Free T/SHBG of an 85 yo guy & no libido for 2 years - help!

    Hi everybody! Stefan here - longtime reader and fan of this forum and web site. I've got some real puzzling libido/testosterone issues and have reached an impasse about what to do next. I'm 33 years old, married, have kids and would like more. Body fat somewhere between 15% and 20%. Main...
  15. A

    Results of 4-speciment salivary cortisol test

    Hi there, I introduced myself in this thread. Here is the result of my cortisol test. Assuming the lab has not screwed up the samples, they are in this order: 1-Ten minutes after spontaneusly waking up around 3 am. (Yes my slep is that screwed up.) 2-After coming home from a long hike, 1 pm...
  16. H

    Pregnenolone (cream) + Test Cyp + HCG. Start together or not?

    Dr. Saya just put me on Test Cyp + HCG and Pregnenolone/DHEA cream (my first consultation). But I forgot to ask him during the consultation if I should start Test / HCG first to feel it out, symptoms wise, before introducing another variable (pregnenolone cream - for low noon cortisol...
  17. G

    Low morning temps

    My morning temps have been low for a long time. Usually around 96.2F. Afternoon and evening temps don’t even go above 97.6F. I’ve had an immense amount of brain fog for 3 years now. Is thyroid and low cortisol usually the reasons for low basal temps, or is there other reasons I should know...
  18. B

    What tests should I request for my symptoms?

    Symptoms: - difficultly getting going each morning - crash between the hours of 1-4PM every day - perk up in the evenings Suspect some sort of adrenal dysfunction. DHEA-S: 424.5 ug/dL (102.6 - 416.3) Progesterone: 2.62 ng/mL (<1.40) 40 y.o. male, 6'1", 200#, 15 mg Clomid ED. 5000IU D-3...
  19. Nelson Vergel

    Late-night salivary cortisol accurate test for Cushing's syndrome in obesity, PCOS

    “Late-night salivary cortisol measurement has recently gained widespread acceptance as a non-invasive, reliable and easy-to-perform test in the diagnosis of Cushing's syndrome,” Hande Mefkure Ozkaya, MD, of the department of endocrinology and metabolism at Cerrahpasa Medical School, University...
  20. Nelson Vergel

    Cortisol Regulation (an Overview)

    By James Wilson, DC, ND, PhD Cortisol is responsible for many life-sustaining functions. Although cortisol is secreted by the zona fasciculata in the adrenal glands, it is regulated primarily by the brain. The amount of cortisol circulating at any particular moment is regulated by a complex...
  21. Nelson Vergel

    One capsule of fish oil daily lowers cortisol levels

    One capsule of fish oil daily lowers cortisol levels A modest dose of one gram of fish oil per day lowers cortisol levels, write Italian researchers in Molecular Nutrition & Food Research. http://www.ergo-log.com/one-capsule-of-fish-oil-daily-lowers-cortisol-levels.html
  22. Nelson Vergel

    Cortisol, Testosterone, and Coronary Heart Disease

    Abstract Background— There is a popular belief that chronic stress causes heart disease through psychoneuroendocrine mechanisms. We have examined whether an elevated circulating cortisol-to-testosterone ratio increases the risk of ischemic heart disease. Methods and Results— We undertook a...
  23. R

    How to increase cortisol?

    I have adrenal fatigue. I have panic attacks at night. My doctor told to me I have panic attack at night because my cortisol is low at night. I think he is right because cortisol = water retention. and I noticed I lose water when i had panic attack. btw, I have always water retention and my...
  24. Nelson Vergel

    Water Retention Caused by Testosterone May Have Nothing to Do with Estradiol

    I get a lot of emails from men on testosterone replacement therapy (and/or HCG) that feel they have water retention (some with ankle swelling) and they are puzzled that their estradiol is low or below 35 micrograms/ml. They may have tried anastrozole treatment without any success in decreasing...
  25. Nelson Vergel

    Tired of Being Tired?- A New Fatigue Exploration Panel Can Help

    Fatigue is can be very frustrating for many people since it can have several causes. There's the normal tiredness we feel at the end of every day, the tiredness that comes from being a hard-working person. But sometimes that fatigue goes beyond just the "norm". It pervades your muscles, fogs up...
  26. Nelson Vergel

    Morning cortisol rules out adrenal insufficiency

    BOSTON &#8211; A random morning serum cortisol above 11.1 mcg/dL safely rules out adrenal insufficiency in both inpatients and outpatients, according to a review of 3,300 adrenal insufficiency work-ups at the Edinburgh Centre for Endocrinology and Diabetes. The finding could help eliminate the...
  27. J

    High Cortisol Question

    I recently had some 8 am blood work done. My cortisol came back fairly high at 21.5(ref range 3.1-22.4 ug/dl. Has anyone else had a high cortisol reading? I haven't started trt yet. I've read where trt can lower cortisol.
  28. N

    Cortisol results interpretation and stress issues

    My salivary cortisol results are as follows: 200ng/dL 6am 200ng/dL 11am <50ng/dL 5pm <50ng/dL 10pm I'm curious if these level are adequate for a normal response to stress. I am having a difficult time coping with stress.
  29. Nelson Vergel

    Sugar-sweetened beverages suppress cortisol, stress responses in brain

    Sugar sweetened beverages suppress cortisol,stress responses in brain. Tyron MS, et al. J Clin Endocrinol Metab. 2015&#894;doi:10.1210/jc.2014*4353.April 16, 2015 The hormone cortisol and stress responses were suppressed with the consumption of sugar* sweetenedbeverages, according to recent...
  30. Okian

    Thyroid test and dexamethasone suppression test!

    I have done a scan for adrenal glands, and doc said everything looks perfect, no need to worry about any tumor or something like that..also a dexamethasone suppression test and thyroid as well, I would appreciate your thoughts on the following please : Thyroid : FT4 - 20.87 pmol/L (10.6 -...
  31. Nelson Vergel

    Are you tired even with normal testosterone? Adrenal fatigue may be the problem.

    Adrenal fatigue is a collection of signs and symptoms called a functional somatic syndrome where there are imbalances that cause the reserve present in the adrenal gland to be depleted below the necessary level. When evaluating healthy adults, some studies have found that 40 percent of people...
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