dopamine

Curated By Nelson Vergel | ExcelMale.com | Updated May 2026 Key Takeaways • Adderall withdrawal is a neurobiological process, not a willpower failure - your brain physically downregulates dopamine receptors during chronic use. • Full recovery of the dopamine...

I started .5mg twice a week and have noticed noticeable improvement in sensitivity/libido/orgasms Anyone on this? What dose? How's it been for you long term? Wondering if this is something you can take sporadically and still get an effect? I have selegine on hand and thought about trying a low...

Does anyone have experience with crushing their prolactin levels down to almost nothing? My prolactin levels have always sat mid range and as I get older I’ve noticed my refractory period isn’t quite as great as it used to be. It’s got me curious about prolactin and whether I should try...

I came across this paper and found it a great reminder of how refined the dopamine system actually is. Below is a concise, plain-English summary you can skim. Big picture The paper asks not just how much dopamine (DA) is released, but where, when, and how precisely it acts in the brain. Old...

Again would tread lightly on how high you run your trough/steady-state FT level! This can easily backfire in the long-run for many especially when it comes to mood, libido and erectile function! Too high a FT level can be just as bad in many ways as having too low a FT level. Libido starts in...

Hello, Does anyone have any protocols with supplements for conservative dopamine agonism? Also, how do you cycle these? I am not ready to take the plunge with something more aggressive like the Parkinson's medications or Selegeline. I am just looking for a slight lift with dopamine. I am well...

In this video, Dr. Soania Mathur interviews Dr. Michael Okun about emerging therapies for Parkinson’s, including continuous infusion levodopa, cell replacement research, repurposed diabetes medication, and more! Chapters: 0:00 - Introduction 2:27 - Advances in Carbidopa and Levodopa 9:48 -...

USE OF THE CNS AGENT BREMELANOTIDE IN MEN WITH SEXUAL DYSFUNCTION: RESULTS FROM A SEWXUAL MEDICINE CLINIC Sue W. Goldstein, Irwin Goldstein*, San Diego, CA INTRODUCTION AND OBJECTIVE Bremelanotide is FDA approved for premenopausal women with generalized, acquired hypoactive sexual desire...

https://academic.oup.com/jsm/article-abstract/21/3/197/7614825?redirectedFrom=fulltext Introduction Hyperprolactinemia, defined by elevated levels of prolactin,has a significant negative impact on sexual function through effects such as reduced sexual desire in men and women and erectile...

Not sure what thread to put this under— I have gained about 51 pounds since 2018 of mostly abdominal fat. I have noticed at a higher weight, I am not feeling as though my TRT is working long enough. I’m guessing it is getting converted into E2 and/or not hitting the receptor sites as my Free T...

Dr. Khera! Abstract Introduction Anorgasmia is a poorly understood phenomenon defined as either a lifelong or acquired consistent inability to achieve ejaculation. Despite the prevalence of anorgasmia, there is currently no established treatment for the condition. Aims To report a unique...

Thought I would start a discussion about this awesome lesser known peptide, yet one of the peptides with quite a few actual human studies behind it. So I'll start with my experience before getting to the science: I have done a few cycles (they last 5-7 days of 8-10 mg) of it this year and...

https://podcasts.apple.com/gb/podcast/228-goat-dr-irwin-goldstein/id1495710329?i=1000627359948 Great interview with one of the all time greats! Fellow Canadian. He is the director of San Diego Sexual Medicine. Dr. Goldstein has had a long career providing medical help to those with sexual...

Ive been circling around this for a while now. When I started(2020) TRT it was remarkable. I could inject 200mg a week. Sometimes 250-300 a week. Last year it all started spiraling down hill. I didnt notice that it was the trt, so I changed up numerous other things I was doing. Sex drive went...

In this clip, Dr. Wayne Hellstrom explains how dopamine agonists can improve men's sexual performance if taken properly and weigh potential side effects.

This is more of what’s everyone’s opinion. When changes are made to testosterone dosages, let’s say lowering it for this instance. How much of those depressed, anxiety, no drive or libido type of feelings that come following a reduction in dosage, do you believe are mainly from the brain...

Surgery as a first-line option for prolactinomas (2022) Adam Mamelak ABSTRACT Introduction: Treatment of prolactinomas with dopamine agonists has been the established first-line treatment option for many years, with surgery reserved for refractory cases or medication intolerance. This...

Hey guys, I wanted to ask if anyone has any tips on lowering norepinephrine levels. I read a thread in regards to doxazosin here on EM, I don’t have a PCP to ask in regards to an Rx to attempt, and I also fear that being only 28 and attempting to ask for this script I would get rejected. So I...

I have kept a crude TRT journal over the last several years, adding notes every week or so. On occasion, I will review the journal to spot any patterns or conclusions that I can draw with a reasonably high degree of certainty. This is how I often find myself repeating the same mistakes over...

Hi all, Andrew Huberman and Derek from more plates more dates on YouTube have collabed to make a hormonal based podcast that is 3 hours long. In addition Huberman lab podcast has a wealth of new health protocols that one can follow to optimize everything from hormones to dopamine baseline...

What effects, if any, does TRT have on neurotransmitters, particularly on serotonin? I know that in the initial stages of TRT, there is a pronounced effect on dopamine - I have been told that this is what causes the "honeymoon" that many guys experience. Are there neurotransmitter imbalances...

As with anything in life, one size does not fit all. So the following is anecdotal as in my subjective experience with Nandrolone Decanoate. When in last December chatter on the forum started to become louder on people adding Nandrolone to their protocol, I decided to go to my local friendly...

After taking it for less than 2 weeks, I've given up TRT androgel testosterone therapy since hair loss is a symptom I cannot risk possessing. Recently I read an article about a med that docs prescribe to boost dopamine levels in the brain that in turn boosts libido. Sadly I can't find this...

Hello ! I'm 33 years old. I've chronic fatigue, depression and no libido (and no morning erections. Erections are good if I get horny.) all of my life. I often feel nervous too much and experience anxiety (including social. I'm an introvert). I have apathy which progresses with time. Also I...

I was talking to my doctor about lack of motivation due to no available stimulants to get me going hard in the gym... I have taken Modafinil in the past but it took about 300 to 400 mg's to get an effect which felt like old-school ephedra but I'd end up awake for a few days... and then it...

Without dopamine, we wouldn't be able to feel pleasure or motivation. It is also very important for our emotional responses, movement, pain, and the brain's pleasure and reward center. Many people seek out artificial sources of dopamine, which can lead to addiction. Read this post to learn about...

Dopamine is an important neurotransmitter, one whose functions is myriad and includes motor control, pleasure response, and habit reinforcement. Levels of dopamine in the brain have long been linked to a feeling of well-being, impulsivity control, and creativity. In a study in Behavioral...

'Dopamine is the neurotransmitter that seems to make life itself rewarding. In this post, I'll teach you how to fuel your brain with dopamine supplements. Dopamine is the motivation molecule. It makes your favorite activities exhilarating and life accomplishments satisfying. Optimizing the...

IN BRIEF Using electric headphones, I zapped my brain's pleasure center. Here's what that's like. ALL OF THE FUN, NONE OF THE WORKOUT If you think about it, every company exhibiting at CES is trying to sell the same thing: happiness. But of the booths I visited last week at the yearly...

This a very good read: "Dopamine. It's at the core of our sexual drives and survival needs, and it motivates us to do just about everything. This mechanism within the reward center of the primitive brain has been around for millions of years and has not changed. Rats, humans indeed, all mammals...