estrogen

Women’s sex lives are being quietly destroyed, and their doctors don’t even know it… Sexual medicine specialist Dr Rachel Rubin reveals the hidden hormone crisis, how prescription drugs can impact sex, and the treatments most doctors aren't prescribing like Hormone Replacement Therapy. Dr...

In this episode of Pearls & Perspectives, host Amy Pearlman, MD, is joined by Larry Lipshultz, MD, and Rachel Rubin, MD, on the sidelines of the 2026 American Urological Association (AUA) Annual Meeting in Washington, DC, for a wide-ranging conversation on advocacy, sexual medicine, and the...

In this episode of unPAUSED, Dr. Mary Claire Haver sits down with Dr. Kelly Casperson, a urologist, author, and host of the podcast “You Are Not Broken”. Dr. Casperson trained in a specialty that treats both men and women, which gave her an early and clear view of the gender gap in sexual...

Hello! I did my bloodwork today after having ED problems for about 2 months. I noticed my estrogen is abnormally high and also the progesterone. I Can understand the high levels of estrogen, but not the progesterone. What could be the culprit to cause it? The weird thing is that. I have no...

A major shift just happened in menopause care. With the FDA removing outdated boxed warnings on hormone therapy—first announced in November 2025 and finalized in February 2026—we’re entering a new era. But what’s actually changed, and what does it mean for patients and clinicians? Join Dr...

https://www.auanet.org/about-us/media-center/press-center/aua-hhs-fda-cdc-to-launch-landmark-womens-health-partnership BALTIMORE, March 12, 2026 (GLOBAL NEWSWIRE) — The American Urological Association (AUA), together with the Urology Care Foundation (UCF), is proud to announce a new formal...

In this episode, Dr Louise Newson is joined by urologist, educator and hormone health advocate Dr Kelly Casperson to challenge some of the most persistent myths surrounding testosterone and women’s health. Drawing on both clinical experience and scientific evidence, they explore why testosterone...

Hey guys, Would appreciate some input on this pattern. I’ve been experiencing ongoing low energy for the past few years — mainly a lack of morning drive and waking up feeling flat or unmotivated. I wouldn’t describe it as depression, but my baseline motivation definitely feels lower than it...

* Estrogen signaling: Estradiol binds nuclear and membrane receptors to regulate gene expression and mitochondrial function; it enhances insulin sensitivity and browning in fat cells, with receptors like ER-alpha feminizing fat distribution. The biology of fat tissue, estrogen's role in...

* The investigators plan to explore the direct role of these sex-specific hormones in regulating blood flow to the brain by blocking hormone production in healthy males and females and giving back testosterone and estrogen, respectively. The investigators will then conduct a range of tests to...

The FDA just held a hearing on menopause—and experts say it’s time to rethink hormone labels. Dr. James Simon joins Fempower Health to explain what needs to change and what it means for women. Chapters: 00:00 Intro – Why This Conversation Matters 00:14 Why Estrogen Labels Matter 00:20...

Hey folks - new here, long time lurker though! Started TRT around 9 weeks ago. 42 yrs old. 120 a week of cypionate, 500 x 2 hCG weekly. So far, feeling good. My starting stats in SI units: Total test: 10.4 nmol/L Free test: 248 pmol/L Estradiol: 59 pmol/L At a recent blood test around 8...

FDA Commissioner and subject matter experts from the Center for Drug Evaluation and Research discuss the agency's recent announcement regarding removal of the “black box warning” for hormone replacement therapy. Proposed Changes Related to Safety Information Labeling Proposed...

Dr. Davis cutting deep here! 27:30 HRT loses its black box warning 29:29 The harm of over prescribing and big dose HRT There is a lot we don’t know about the menopause. It’s a stage of life that can be difficult to navigate for many women - especially since the advice online is all over...

Dr. Rachel Rubin and Dr. Kelly Caspersen discuss with FDA Commissioner Dr. Marty Makary the significant impact of hormone replacement therapy (HRT) on women's health, particularly in the context of recent FDA changes to black box warnings. They explore the misconceptions surrounding HRT, the...

Hi guys, ive been in trt for 4 years. Last 2 years ive been using 18-20mg/daily of cypionate. My estrogen during all This time has been fluctuating between 50-70. The liver enzymes, specially alt, has been high too (60-90). My doctor says the estrogen is ok, and he like as high as posible. On...

Researchers proposed the idea of an “testosterone deficiency syndrome” in menopausal women more than 20 years ago. This was before testosterone had been measured across women’s lifespans and before robust studies of the relationships between blood testosterone levels and specific symptoms. Our...

Cindy Eckert, CEO and Founder of Sprout Pharmaceuticals, made history by bringing Addyi — the first and only FDA-approved drug for hypoactive sexual desire disorder (HSDD) in women, also known as low libido — to market. In 2015, Eckert sold Sprout Pharmaceuticals for a record-breaking $1...

Preally really need help! Im battling this for the past year! My sleep is horrid and im getting suicidal because i cannot sleep, i feel trapped, it feels like there’s no end. My sleep is like 1 hr sleep, wake up, 1 hr sleep, 4 hrs awake, 30mins sleep. Did enclomiphene in Aug 2024 - few weeks &...

Dr. Alison Shea hosts an audience Q&A on menopause at the Women's Health Symposium in Calgary, presented by Calgary Health Foundation, the University of Calgary’s O’Brien Institute, and the Sex, Gender, and Women’s Health Research Hub.

In this episode of You Are Not Broken, Dr. Kelly Casperson sits down with Dr. Carrie Cashel to explore the overlooked connections between testosterone, mental health, and women's wellness. From the impact of hormones like testosterone and DHEA on brain health to the hidden role of mast cell...

This was a very important meeting with top experts that are trying to change guidelines. This FDA panel recently recommended removing the warning (“black box”) labels on menopausal HRT, citing potential benefits like reduced heart attack and bone fracture risk—and arguing the warning discourages...

Dr. Sheryl Kingsberg discusses the most prevalent sexual health concern for women of all ages (HSDD). She offers tips on how to open the discussion, reviews the various screening tools, and outlines the treatment options.

* injections can be very hard to titrate to get to the right amount The Side Effects of Testosterone in Menopause and Perimenopause // Have you been considering testosterone but also wondered about the possible side effects? In this video, I break down the most common side effects of...

Double board certified OBGYN and REI, Dr. Natalie Crawford discusses testosterone in women, its role in hormone balance, and its impact on fertility. She explains how testosterone interacts with estrogen and progesterone, why random testosterone level measurements can be misleading, and how...

After trying many protocols over the last 3yrs, I've ended up trying compounded testosterone cream. My initial starting dose was 75mg (2 clicks) morning and evening. I believe this starting dose was given because I was previously on 150mg cypionate a week. I went to get my thyroid test...

https://www.endocrine-abstracts.org/ea/0109/ea0109p341 Introduction HSDD is characterized by long-term decrease in sexual desire (low-libido) causing personal distress. HSDD predominantly affects postmenopausal women or following oophorectomy. Despite the clear indication that testosterone...

In this informative video, Dr. James Simon, a renowned expert in women's health, discusses significant advancements in menopause management as of 2024. He highlights four notable publications from 2024 that delve into the latest research on menopause, providing valuable insights for both...

Hello everyone, Desperate for some help. I’m 23 years old. I’ve been bodybuilding for 8 years, and started competing at 21. I was prepping to compete at nationals this summer before everything went wrong. I was on a test only cycle around June and started to get some gyno symptoms. All I...

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