hpta

* We evaluated, for the first time in humans, whether chronic subcutaneous (SC) administration of kisspeptin-10 (KP10) can sustain gonadotropin secretion without desensitization. * This study provides the first evidence that chronic SC KP-10 administration can sustain gonadotropin secretion in...

* Fertility preservation remains an important consideration in the management of hypogonadal men. While exogenous testosterone therapy effectively alleviates symptoms, it suppresses the HPG axis and impairs spermatogenesis. Alternative therapeutic strategies—including short- acting formulations...

In this video, Dr. Jonathan Clavell—board-certified urologist and men’s health specialist in Houston, Texas—breaks down exactly how testosterone works, where it comes from, how it’s regulated, and how we test and treat it. Learn about: • The connection between your brain and testicles that...

Increased prescription of opioid medications like oxycodone and hydrocodone has led to widespread misuse of both prescription and non-prescription opioids. But did you know that opioid misuse can significantly impact the endocrine system? The Endocrine Society recently published a scientific...

https://pmc.ncbi.nlm.nih.gov/articles/PMC12544852/pdf/bvaf149.2003.pdf Author Block: Ashley Kieran Clift, Jeff Foster, David R. Huang. Manual (Menwell Ltd), London, United Kingdom. Disclosure Block: A.K. Clift: I am an employee of Manual (Menwell Ltd), a healthcare provider that provides...

https://academic.oup.com/jsm/article/21/Supplement_6/qdae161.205/7916870 Abstract Introduction The management of male infertility, particularly that induced by the use of anabolic androgenic steroids (AAS), presents a significant challenge in andrology and urology. Anabolic steroids are...

* Samples of venous blood were obtained from 22 healthy adult males age 19-26 before and after the im injection of testosterone in aqueous suspension (Oreton©). * The administration of the 12.5 and 25.0 mg of testosterone daily was reflected by markedly higher levels of serum testosterone...

39 male. Mixed training for 15+ years. Have run a few 6-8 week test/var/and SARMS cycles (rad140, mk2866). Regularly cycle GHRH/GHRP cycles for anti-ageing and skin. Have experimented with Enclo and kisspeptin to increase LH/FSH with some success. Love Proviron. Never been on TRT. Very sensitive...

This is gold really enjoyed this one! Worthy of a sticky! Spermatogenesis Induction: A Comprehensive Guide to Male Fertility Treatment Professor Dimitrius Goulis delivers an expert overview of when and how to induce spermatogenesis in men with hypogonadism Introduction Male...

Hot off the press, Nelson's domain is where it's at! *30 patients with TRT induced infertility were treated with doses of HCG ranging from 500 to 3000 IU every MWF. Nine patients were lost to follow up. Median length of follow-up was 4 months (1-10 month range). Average length of TRT use was...

I noticed today my testicles are moving again just as they did in 2019 after stopping TRT and earlier in life. My testicles are constantly moving, twisting and rotating around each other. I do have some testicular pain on and off. I'm starting to wonder if this was my original medical issue...

Testosterone deficiency can be a devastating condition associated with adverse emotional and physical conditions, but it should not be the first answer to the problem. Understanding that trauma induced neuroinflammation and medication such as Ibuprofen can cause testosterone deficiency. A...

Are there significant difference between Clomiphene citrate and Enclomiphene citrate to warrant using one over the other? I will explain some of the Pros and Cons of each and then discuss our outcome experiences and side-effects in over 800+ clients. I address our 2014, three-year clinical...

After nearly 15 years of providing clomiphene citrate as an initial alternative approach to testosterone replacement therapy for hypogonadism, I am releasing the article "The Application of Clomiphene citrate in the Management of Hypogonadism Secondary to Concussive and Subconcussive Brain...

TL;DR: Some research suggests that echinacoside may complement a SERM in reducing TRT-induced negative HPT-axis feedback at the hypothalamus. Background: In testosterone replacement therapy, elevated levels of testosterone and estradiol apply negative feedback to the hypothalamus. This...

Gonadotropin-Releasing Hormone (GnRH) is a peptide controlling reproductive functions. It binds to GNRHR receptors and has diverse effects. GnRH plays a role in infertility, reproductive disorders, assisted reproduction technology, endometrium, ovary, prostate physiology, tumor transformation...

When the HPTA shuts down due to mono TRT does the pituitary shut down entirely? Or does only the part that controls LH and FSH shut down?

Recovery of male reproductive endocrine function after ceasing prolonged testosterone undecanoate injections (2022) David J Handelsman, Reena Desai, Ann J Conway, Nandini Shankara-Narayana, Bronwyn G A Stuckey, Warrick J Inder, Mathis Grossmann, Bu Beng Yeap, David Jesudason, Lam P Ly, Karen...

Triptorelin is used clinically to produce castration by suppressing LH and FSH, being agonistic but constant stimulation produces the opposite effect. It has been claimed that a single dose of 100 mcg would be fine to restore HPTA. I would like to have some input on this...

Read this chapter. Chapter 12 - Hypothalamo-Pituitary Unit, Testis, and Male Accessory Organs https://www.sciencedirect.com/science/article/pii/B9780323479127000123?via%3Dihub From https://www.sciencedirect.com/book/9780323479127/yen-and-jaffes-reproductive-endocrinology

I'm attempting an HPTA restart, in the past when I used to cycle, the norm was to take Nolvadex and Clomid together. I've had pretty good success with that but I haven't done that in years. I'm seeing a lot of people suggest and clomiphene only when they decide to attempt a restart. I'm...

Hi everyone. I will be attempting to have my wife achieve pregnancy after being on TRT for long over a decade WHILE continuing to stay on TRT. I’ll be doing 50mg SQ TC shots twice a week (M-Th) while taking 300ius of HCG three times a week. I plan on doing this for 8-9 months then adding HMG...

I was on trt then got off and recovered successfully with clomid after four months. I then made the decision to get back on trt after I had fully recovered. It has been six months now and I can tell I’m still low t, and I’ve been struggling with the idea of getting on trt permanently but I...

I made a post about this on another forum, but decided to make one here too, in case someone cares haha. I quit trt on June last year, and started hcg. Was on testosterone injections for few years. I was on hcg for a bit over 6 months, and one month ago I switched it to clomid. This is all...

When I plan on discontinuing TRT and restarting my HPTA so I can get fertile. Do I need to take anything to combat gyno. I plan on 3000mg HCG three times a week with 20mg Clomid daily. I want to make sure I don’t get gyno doing this. Can anyone recommend what I should I do?

Does anyone have any experience with doing an HPTA restart while staying on Propecia? I Plan on using HCG, CLOMID, Nolvadex, HMG and was wondering if anyone was successful at achieving fertility while not discontinuing Propecia. Please no comments about dropping the Propecia. I haven’t come this...

What effects, if any, does TRT have on neurotransmitters, particularly on serotonin? I know that in the initial stages of TRT, there is a pronounced effect on dopamine - I have been told that this is what causes the "honeymoon" that many guys experience. Are there neurotransmitter imbalances...

I've been on HCG from June 15, for an attempt to restart my own testosterone production. My trt doctor prescribed a huge amount of 5000iu 2x week. I did that first, and then spared it out to 2500iu EOD after few weeks, because of the huge 5000iu dose at once seemed to give me elevated heart rate...

Admittedly the last thing we need is some other nebulous danger to worry about that may not even exist. Read on at your peril. TL;DR: Testosterone replacement therapy suppresses the production of GnRH. Receptors for GnRH are found in places besides the pituitary. One animal model suggests GnRH...

I am attempting a restart after a long and thoughtful discussion with my doc. I was advised to take pregnenolone and DHEA during the restart but I was under the impression that this would be suppressive to my HPTA? I always assumed supplementing those two were fine if on TRT, but suppressive if...