kisspeptin

Curated By Nelson Vergel | ExcelMale.com | Updated June 2026 If you've been on TRT for a while and still deal with flat libido or low motivation - even with testosterone in a solid range - there may be more happening than your T levels alone can explain. One underappreciated piece of that...

* Within the arcuate nucleus, a specialized subset of kisspeptin neurons, known as KNDy (Kisspeptin/Neurokinin B/Dynorphin) cells, functions as a “pulse generator,” coordinating rhythmic bursts of activity that drive the pulsatile release of GnRH [3, 4]. * Three healthy adult men received a...

Hey yall Stopping TRT of 100mg Cypionate E5D (peaks 1500 and lows of 1000 test) to have babies. I’m in a peptide mood, studying it a lot and wanna give a shot for them in my PCT but not risking it. Planning to start 20days after last cypionate shot. I have in my hands hCG, ovidrell (real...

* The discovery of kisspeptin neurons in the early part of this century revolutionized our understanding of reproductive regulation. These neurons project to and control GnRH neuronal excitability. More recently, arcuate kisspeptin neurons (KNDy) have been identified as the command neurons...

https://www.obesity-abstracts.org/ob/0005/ob0005oc1 Background Male obesity-related secondary hypogonadism (MOSH) affects two-thirds of men with BMI ≥40 kg/m2 and is associated with increased mortality. Animal models suggest decreased hypothalamic function in obesity-related hypogonadism...

* We demonstrate the clinical potential for intranasal kisspeptin delivery as the first non-invasive method to robustly and safely stimulate gonadotropins with kisspeptin and potentially transform the management of reproductive disorders. * In summary, we provide the first human evidence...

Figure 1. Effects of kisspeptin on reproductive behavior in rodents and humans. Figure illustrates the diverse roles of kisspeptin in modulating behaviors related to sexual partner preference, sexual motivation, arousal/copulatory behaviors, pair bonding, and mood (anxiety/depression) in male...

I have read in this and other forums that taking clomid, gonadorelin, or kisspeptin while on TRT is a waste - that those things are used more for PCT, to regain testicular function. But why is it wasteful, or even contraindicated, to use those medications while on TRT? How does one harm the...

The role of testosterone, the androgen receptor, and hypothalamic-pituitary–gonadal axis in depression in ageing Men https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789012/ Best review on this topic I have seen so far. Might be also very interesting for non-depressed ageing and young men. "In...

Howdy y'all, As I've posted about in the past, I've been taking HCG Monotherapy for low T for about seven years now with good results - my last bloodwork had my total T at 707ng/dL with no change to my total weekly dosage since I started in 2017 (just tweaks to my dosing protocol)...

Enjoyed this one. Pay close attention! (36:00-39:45) Thank you for tuning in to our video discussing the love neuropeptide and what is the role of kisspeptin in sexual behavior. In this video, we delve into the question of what is the role of kisspeptin in sexual behavior. Join us as we...

https://academic.oup.com/endo/article-abstract/165/2/bqad194/7505543?redirectedFrom=fulltext&login=false Abstract There is considerable evidence that synchronized activity within a reciprocally connected population of cells in the arcuate nucleus (ARC) coexpressing kisspeptin, neurokinin B...

https://www.endocrine-abstracts.org/ea/0094/ea0094oc4.4 Background Kisspeptin is a potent regulator of GnRH neurons with the potential to treat reproductive and psychosexual disorders. However, administration is limited to the subcutaneous or intravenous routes. These invasive routes limit...

https://www.yourhormones.info/resources/digital-library/student-video-awards-2023/kisspeptin-s-promising-role-in-treating-hypoactive-sexual-desire-disorder/

https://open.spotify.com/episode/2K3K2Sq0oZgzMGWfCrCr50

Kisspeptin (KP) and neurokinin B (NKB) regulate the reproductive endocrine axis by influencing GnRH activity and secretion. Inactivating variants in KP or NKB signaling can lead to hypogonadotropic hypogonadism and pubertal development failure. KP and NKB offer potential therapeutic applications...

Kisspeptin is looking increasingly promising for improving libido and sexual function. Check out this new study: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898824/ Can anyone (@readalot ?) help me figure out what 1 nmol/kg of kisspeptin translates to in micrograms? That is the dose per...

Big n-1 results update. With all the gym bros telling me for the last 10 years that GH secretatgogue peptides are a scam and a waste of $$$$ - and that good ol' GH is superior and the only way to go - - - Let me preface this post by saying that these peptides do work. I repeat. THESE PEPTIDES...

The arcuate kisspeptin neuron population in a coronal brain slice. Image courtesy of the Herbison laboratory For many years, the ‘KNDy hypothesis’ has been the main mechanistic explanation of the pulsatile secretion of gonadotropin hormones. New research in Cell Reports proposes an...

What is kisspeptin and why are men using it? ExcelMale's guide covers how kisspeptin works, reported benefits for testosterone and libido, and dosing protocols. Novel therapeutic avenues for kisspeptin (2022) Jovanna Tsoutsoukia, Ali Abbarab, and Waljit Dhillo Abstract Kisspeptin is a...

I have a simple question about kisspeptin-10 for you. Does kisspeptin-10 administration cause suppression or shutdown of our kisspeptin endogenous production? If so I wonder, When endogenous kisspeptin is suppressed or shut down during the half-life of kisspeptin-10, can occur neuronal atrophy...

I was speaking to a doc the other day who is in to Hormones and peptides , he said he had a lot of patients who increased their T a lot on Kisspeptin, they however were not on TRT. I wondered if anyone one here was using it with success while on TRT. The reason I am interested in this is that...

Reproductive Hormone Secretion is Increased by Intranasal Kisspeptin in Humans (2022) Edouard G Mills, MBChB MRCP, Magda Swedrowska, Ph.D., Layla Thurston, MRCP, Maria Phylactou, MRCP Ph.D., Bijal Patel, MRCP, Lisa Yang, MRCP Ph.D., Sophie A Clarke, MRCP Ph.D., Beatrice Muzi, MSc, Emma...

Kisspeptin Restores Sexual and Attraction Brain Processing in Women with Hypoactive Sexual Desire Disorder (2022) Layla Thurston, MRCP, Tia Hunjan, MD, Natalie Ertl, MSc, Matt Wall, Ph.D., Edouard Mills, MRCP, Sofiya Suladze, BSc, Emma Alexander, MBBS, Beatrice Muzi, MSc, Bijal Patel, MRCP, Paul...

Kisspeptin Increases Penile Tumescence and Sexual Brain Processing in Men with Hypoactive Sexual Desire Disorder (2022) Ali Abbara, Paul Bech, Alexander N Comninos, Waljit S Dhillo, Natalie Ertl, Dena Ettehad, David Goldmeier, Jonathan Howard, Tia Hunjan, Beatrice Muzi, Bijal Patel, Maria...

Hello all, HCG is getting harder to get. Or also 3x more expensive if you can get the generic brand. A new clinic in town offers Kisspeptin-10. Is this a good alternative? Has anyone here used it before and care to share your results? Greatly appreciate it.

TD;LR: Kisspeptin may affect how we act and feel. It seems plausible that a TRT-induced reduction in this hormone is a problem for some men. I’d previously asked if suppression of GnRH by TRT is a problem. The literature at least hints that it is possible. The situation with kisspeptin may be...

After doing some digging since a clinic i know is no longer using hCG, a called a few pharmacies and found out they are going to be offering Gonadorelin and NOT Kisspeptin. Kisspeptin is a peptide and it is NOT approved to be compounded and states like California will not approve it, while...