Can Kisspeptin be a new treatment for sexual dysfunction?

[madman]

 

[madman]

Figure 1.

 

[madman]

Outstanding questions

 

[madman]

Thread 'Kisspeptin Peptide: Benefits, Dosing & Therapeutic Uses for Men'

Dec 9, 2022

What is kisspeptin and why are men using it? ExcelMale's guide covers how kisspeptin works, reported benefits for testosterone and libido, and dosing protocols.

Novel therapeutic avenues for kisspeptin (2022)
Jovanna Tsoutsoukia, Ali Abbarab, and Waljit Dhillo


Abstract

Kisspeptin is a hypothalamic neuropeptide that acts via the hypothalamus to stimulate hypothalamic gonadotrophin-releasing hormone secretion and downstream gonadotrophin release. In health, kisspeptin induces normal puberty and modulates ovulation in healthy women. Hypothalamic kisspeptin expression...

• madman
• Hssd kisspeptin Reproduction Testostreone
• Replies: 15
• Forum: hCG, Clomid & Others for Fertility, PCT or Low T

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[madman]

This needs to be stressed here especially to all those bros jumping the gun here!

 

[BadassBlues]

This needs to be stressed here especially to all those bros jumping the gun here!



View attachment 55017

Very true sadly... I tried this a year or so ago with limited results, mainly a slight mood elevation. Also, can you elaborate on the differences between those on TRT and those that are not?

I recall that there may be some evidence that Kisspeptin has a hard time crossing the BBB, but don't remember the details.

 

[madman]

* As previous studies have varied in the isoform of kisspeptin used and their pharmacokinetics[50, 51], it is important to remember that kisspeptin-10 and − 54 may differ with respect to thresholds for receptor saturation and desensitization.


* In summary, while our study reinforces previous observations that kisspeptin-10 infusion initially stimulates the hypothalamic-pituitary-gonadal axis, it remains unclear whether prolonged exposure duration will attenuate kisspeptin receptor signaling in eugonadal male. Modulation of kisspeptin receptor signaling in humans is likely to be both time- and dose-dependent.

Thread 'Dynamic Modulation of LH Secretion by Continuous Kisspeptin Infusion in Healthy Men'

Mar 26, 2026

* Within the arcuate nucleus, a specialized subset of kisspeptin neurons, known as KNDy (Kisspeptin/Neurokinin B/Dynorphin) cells, functions as a “pulse generator,” coordinating rhythmic bursts of activity that drive the pulsatile release of GnRH [3, 4].


* Three healthy adult men received a continuous intravenous infusion of kisspeptin-10 at a dose of 12.5 mcg/kg/h for 24 hours


* Continuous administration of kisspeptin resulted in an immediate increase in LH levels, 5 to 10-fold above baseline, which were sustained for several hours...

• madman
• hypogonadism kisspeptin Lh/fsh testosterone
• Replies: 3
• Forum: Testosterone and Men's Health Articles