progesterone

  1. C

    Extremely high estrogen and progesterone on ”TRT”

    Hello! I did my bloodwork today after having ED problems for about 2 months. I noticed my estrogen is abnormally high and also the progesterone. I Can understand the high levels of estrogen, but not the progesterone. What could be the culprit to cause it? The weird thing is that. I have no...
  2. C

    Pregnenolone pathways and outcomes

    I want to start by saying I'm really enjoying the discussions I'm seeing here along with the anecdotes. I believe I've reviewed all of the prior discussions on here regarding pregnenolone but I still have some questions. Does anyone habe any idea why an individual with undetectable...
  3. madman

    Testosterone in Women: What Does Testosterone Do? How Do Testosterone and Hormones Impact Fertility?

    Double board certified OBGYN and REI, Dr. Natalie Crawford discusses testosterone in women, its role in hormone balance, and its impact on fertility. She explains how testosterone interacts with estrogen and progesterone, why random testosterone level measurements can be misleading, and how...
  4. madman

    Ultra-Sensitive LC-MS/MS Method for Progesterone Quantification in Serum: Establishing Reference Intervals in Men

    * Mean progesterone was 170 pmol/L, with 2nd and 97.5th percentiles were 71 and 316 pmol/L, respectively. https://www.endocrine-abstracts.org/ea/0109/abstracts/poster-presentations/adrenal-and-cardiovascular/ea0109p42/ Introduction Progesterone is a steroid hormone commonly measured...
  5. S

    Pregnenolone or Progesterone?

    Pregnenolone serum 87ng (range 22 - 237) My 17-OHP (Progesterone) saliva came out LOW 13 (range 19.5 - 25.9) DHEA serum 110 (range 93 - 415) DHEA saliva 0.37 (0.10 to 1.60) DHEA urine metabolites LOW way below range Cortisol urine metabolites LOW way below range Cortisol saliva perfectly normal...
  6. T

    Is this a cause for concern

    Zero libido - Poor EQ Is there any what to lower progesterone how much of a problem is high progesterone? My prolactin, whilst elevated is this a value I should be concerned about? 140mg test E pinned daily. (I have single digit SHBG since I started TRT.
  7. G

    High Progesterone, Androstenedione and Dhea/s. Not sure what this could mean 34/M

    Long story short, around 10 years ago I took a supplement called 7-keto dhea which gave me panic attacks, and I have had issues ever since. This was the only test I could find that tested for that hormone metabolite. Although I'm a lot better than I was 10 years ago I'm still suffering from the...
  8. madman

    Unraveling the impact of sex hormones on cardiometabolic health

    Abstract This review thoroughly explores the multifaceted roles of sexual hormones, emphasizing their impact beyond reproductive functions and underscoring their significant influence on cardiometabolic regulation. It analyzes the broader physiological implications of estrogen, testosterone...
  9. Gianluca

    Injectable Progesterone SC may not be the best route of administration

    @Cataceous @Gman86 @JA Battle I would like to know your opinion on this I noticed that when I was on the 1,5mg or even worse at 2.5mg dose of Progesterone SC, I would experience some side effects such as being emotional, and way too much on the 2.5mg, and also more body hair growth, crazy...
  10. R

    Progesterone 280% higher, SHBG high, DHEA low, T normal -- should I start TRT?

    Hi. I would appreciate any analysis of my blood tests. Background: - 34yo male (5ft9 & 132lbs /180cm & 60kg) - never been a vegetarian. I eat mostly animal food, no sugar, no gluten. Severe chronic illness since 2013: - extreme tissue fatigue/weakness - super-easily injured - unable to heal...
  11. Gianluca

    Is there a better absorbed subQ injection site?

    Im wondering if all subQ injection site yield to same absorption/levels of injectable medication. I would guess yes, but especially curios to hear anecdotes Im about to start Progesterone subQ but didn’t have good luck with testosterone SubQ, I was injecting on the upper outer part of the...
  12. H

    Pregnenolone levels staying low despite supplementation -blood work incuded; Please Help

    Hello everyone- according to recent blood work I have low pregnenolone levels despite taking the expensive brand of PURE Encapsulations off of amazon ($0.30+/per dose). After taking 60mg for about a month I went from undetectable to still low levels of pregnenolone . I also had my DHEA levels...
  13. Gianluca

    has anyone tried Progest-E for progesterone?

    Hi Guys, Progest-E was formulated by Ray Peat, it is combined with Vitamin E, and should by pass the first pass in the liver. I'm wondering if anyone has tried this before. To my knowledge this is the only oral Progesterone product that skip that first pass in the liver Dr. Peat's Progest E...
  14. madman

    Menopause Myths Debunked

    Dr. Heather Hirsch breaks down myths and misconceptions about menopause.
  15. JayD

    Guidance with Progesterone(Dutchtest results)

    What are most guys using to raise progesterone these days. Or is it not really worth worrying about. Below is my recent Dutch test results. I tried a Nootropics Depot 5mg sublingual tab for the last week but can barely tolerate even 2.5mg per day. Makes me feel on edge and seems to make me talk...
  16. W

    High progesterone levels from blood work

    Hi guys, Looking for some advice following some recent blood work I’ve had. I’ve been suffering with erecitle dysfunction for a very long time now. Pretty much since I was sexually active in my early 20s which makes me believe I have some fairly major hypogonadism. I never could really...
  17. B

    Need some help with dosing Progesterone. Did I over shoot the mark?

    Hi Gents, Have been a long time reader of the forum but this is my first post and just hoping to get some insight and advice around Progesterone supplementation. It has only been fairly recently I decided to investigate and look into the possible other missing parts of my TRT protocol. I was...
  18. madman

    Menopausal hormone therapy with estradiol and progesterone vs other estrogensand progestins

    Review of menopausal hormone therapy with estradiol and progesterone versus other estrogens and progestins (2022) Shelli Graham, David F. Archer, James A. Simon, Kathleen M. Ohleth & Brian Bernick ABSTRACT Objective: The objective of the present document was to review/summarize reported...
  19. BradockTRT

    dose of progesterone

    oi gente que está usando creme de progesterona qual a dose que você está usando?
  20. FunkOdyssey

    TRT doesn't cause deficiency of Preg/DHEA/Prog and HCG doesn't fix it

    That is the bold claim made by this user on Reddit: What do you guys think? Is this why most men on TRT are doing well without supplementing the upstream hormones?
  21. madman

    British Menopause Society update on HRT supply

    https://thebms.org.uk/news/british-menopause-society-update-on-hrt-supply/ The British Menopause Society has issued an update on HRT supply to provide guidance to BMS members and clinical practitioners on the current availability of HRT products. The British Menopause Society very much...
  22. Gianluca

    Pregnenolone IR vs SR

    Curios to know if anyone has noticed some differences between the two. My Progesterone increases more with IR compared with SR, .4/.5 compared to .7/.8.
  23. madman

    Progestogen-mediated neuroprotection in central nervous system disorders

    Progestogen-mediated neuroprotection in central nervous system disorders (2022) Bassani TB, Bartolomeo CS, Oliveira RB, Ureshino RP Abstract Neuroactive steroids can be synthetic or endogenous molecules produced by neuronal and glial cells and peripheral glands. Examples include estrogens...
  24. madman

    Feeling confident prescribing HRT and Reclamation of Testosterone

  25. G

    Does Progestelle bio identical progesterone oil show up on serum blood tests?!

    I ask because I got labs back today showing my progesterone actually went down from.5 to .3 from my last test a year ago. I’m reading conflicting information on this and on the material that Progestelle provided it states that “Progesterone will not show up on serum testing, only saliva testing”...
  26. R

    On TRT and low lobido

    Hi Guys, I’ve been on TRT for a while now and take the following meds regularly. Current meds I’m on: Test Cyp - 0.3ml x 2 times a week 200 mg/ml (so thats 60mg twice a week) Anastrozole - 0.5mg x 2 times a week I’ve noticed that I have been lacking in sexual desire most of the time. I can...
  27. M

    Could progesterone use crash estrogen or cause joint pain?

    Hello, for the past 2 weeks I’ve been using progesterone cream, one pump scrotal application per day. Over this weekend I started to notice my joints were achy, felt sort of dry, popping a bit. I’ve actually been feeling pretty good (libido and mentally) but thinking I may have overdone it with...
  28. M

    Men: What has been your experience with progesterone?

    Sorry, I know there are a ton of other threads on progesterone, but seems like a lot of them get derailed and you have to filter through like 12 pages of comments and studies people posted. I just want to know straight up, what has been your experience with progesterone? For me, I’m on day 5...
  29. A

    Progesterone as Anti-Estrogen

    Hi All, this is my second post here and it is going to be a long one so please bear with me. I am amazed at the quality and depth of information available here, and grateful for the advice and help that experienced men on TRT provide here. Bloodwork : (After 3 months on TRT) Total...
  30. G

    Progesterone and fertility in males

    Does anyone know whether exogenous progesterone increases or decreases fertility in males?
  31. E

    Any men here take progesterone orally?

    What's your dose?
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