serm

  1. M

    Nolvadex severe sides?

    Hello I hope this is the right place I'm new here. I self administered TRT for 8 months and decided it was too hard to manage on my own even with getting regular labs etc. it seemed like no matter what I did it would spike anxiety. I already have anxiety issues so I didn't see the benefits...
  2. M

    Advice on PCT Protocol After 3 Years on TRT?

    Hi everyone, I’m looking for advice on the best way to structure my PCT after being on TRT for about 3 years, specifically whether enclomiphene should overlap with HCG or only after HCG is discontinued. Here’s my full background and current plan: TRT History On TRT for ~3 years total Started...
  3. R

    Can enclomiphene or tamoxifen have favorable effects on intratesticular testosterone

    Background to question: There are primarily 2 indications for using medication to increase LH stimulation of the testes during TRT: 1. Preservation of spermatogenesis (Fertility) 2. Preservation of intrinsic testicular production of testosterone (and estradiol) (avoidance of testicular...
  4. madman

    Clomiphene or enclomiphene citrate for the treatment of male hypogonadism: a systematic review and meta-analysis of RCTs

    https://www.aem-sbem.com/article/clomiphene-or-enclomiphene-citrate-for-the-treatment-of-male-hypogonadism-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials/ ABSTRACT Objective This study aimed to evaluate the efficacy and safety of selective estrogen receptor modulators...
  5. madman

    The Cost of Clomiphene for Male Infertility Treatment: Compounded vs Brand name

    Hot off the press, Nelson's domain is where it's at! * The weighted mean price per pill for clomiphene 25mg, clomiphene 50mg, and Clomid were $2.21 ± 1.24; $2.60 ± 1.49; and $8.41 ± 1.53, respectively, from compounding pharmacies. In comparison, the national Clomid retail pharmacy average...
  6. madman

    Absolute Pharmacy - Enclomiphene Citrate

    https://absoluterx.com/ https://direct.absoluterx.com/home
  7. K

    Permanent ED from tamoxifen?

    Hello. So my doctor gave me tamoxifen for low t and I only took 5 pills (20mg) eod. Didn’t help with the symptoms only gave me severe loss of libido, ed and anhedonia. Then we changed to sustanon 250mg every 10 days. My doctor said symptoms of tamoxifen will go away in “couple of weeks” And I...
  8. Pnw0031

    Raising SHBG using raloxifene

    Curious if anyone has raised shbg using a SERM like raloxifene, a new blood test shown my shbg was even lower- 11! It’s likely my shbg was lowered via Proviron given to me by my endo (she is an idiot but that’s besides the point). I do have some raloxifene I’d like to use to raise my shbg to...
  9. madman

    ENCLOMIPHENE IS ASSOCIATED WITH HIGHER PREGNANCY RATES WHEN COMPARED TO CLOMIPHENE IN INFERTILE MEN WITH LOW T

    MP43-13 ENCLOMIPHENE IS ASSOCIATED WITH HIGHER PREGNANCY RATES WHEN COMPARED TO CLOMIPHENE IN INFERTILE MEN WITH LOW TESTOSTERONE (2023) Jordan Kassab, Juan Torres-Anguiano*, John Lindsey, Houston, TX; Jabez Gondokusumo, Sabine Itani, Mohamad Jabin, Bryan, TX; Larry Lipshultz, Houston, TX...
  10. madman

    THE EFFECT OF CLOMIPHENE CITRATE ON PATIENT REPORTED OUTCOME MEASURES

    PD11-12 THE EFFECT OF CLOMIPHENE CITRATE ON PATIENT-REPORTED OUTCOME MEASURES (2023) Jessica Schardein*, Kia Fendereski, Zane Randell, Soren Keihani, Joshua Horns, James Hotaling, Salt Lake City, UT INTRODUCTION AND OBJECTIVE Clomiphene Citrate (CC) is a medication that can be used in...
  11. madman

    Novel androgen therapies including SARMs

    Novel androgen therapies including selective androgen receptor modulators (2022) Jungwoo Kang, Foundation Year 1 Doctor, Runzhi Chen, Medical student, Tharu Tharakan, Urology Registrar, Suks Minhas, Professor of Urology Male hypogonadism is associated with reduced quality of life and the...
  12. madman

    Clomiphene May Take 9 Months to Fully Restore Sperm Count

    Temporal Changes of Clomiphene on Testosterone Levels and Semen Parameters in Subfertile Men (2022) Tommy Jiang, John T. Sigalos, Vadim Osadchiy, Alvaro Santamaria, Michael H. Zheng, Neilufar Modiri, Keith V. Regets, Jesse N. Mills, Sriram V. Eleswarapu Purpose: Clomiphene citrate (CC) is...
  13. J

    Trying to do a HPTA restart with my doc…29 days in my total T is only 18:(

    My labs are attached. Total T is only 18, and free T is only .3!!! Okay have no libido whatsoever. My dick gets hard, but I have no interest in using it, and I don’t orgasm at all. I was on TRT for nearly 2 years, and tried to come off recently. I stopped my test Cypionate injections 29 days...
  14. B

    Standalone SERM as monotherapy??

    Hey guys (and Admins) I'm looking for some pick me up. I'm 44 and have lowish test; my libidio and work drive are down these last few years. Will a standalone SERM help?? I'm a 2 times a week gym goes. 6'2 230lb ex athlete. I've never done anything more than protein powder before. I've...
  15. H

    SERM instead of HCG for TRT

    I have read some posts about the possibility of using a SERM like clomid or tamoxifen instead of HCG in order to keep tests functioning while on TRT. I did an experiment and just wanted to post my results (take the information as is and hopefully it helps to answer some questions you might...
  16. Nelson Vergel

    A SERM (fispemifene) increases testosterone but not sex drive

    Shares of San Diego-based Apricus Biosciences were crushed this morning after the biotech reported that its experimental testosterone-boosting drug had failed both the primary and secondary endpoints in a Phase IIb study among men with secondary hypogonadism and sexual dysfunction. And the...
  17. R

    The endocrinologist's guide to managing self-treating patients

    Male Central Hypogonadism Secondary to Exogenous Androgens Clin Endocrinol. 2015;82(5):624-632. In this paper a group of clinicians acknowledges that practitioners are encountering an increasing number of patients seeking help with recovery from self-administered anabolic steroids. [...
  18. Nelson Vergel

    A New SERM to Raise Testosterone : Fispemifene

    SAN DIEGO, June 1, 2015 (GLOBE NEWSWIRE) -- Apricus Biosciences, Inc. (Nasdaq:APRI), a biopharmaceutical company advancing innovative medicines in urology and rheumatology, today announced that it has begun enrolling patients in a Phase 2b clinical trial to evaluate Apricus' novel product...
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