Advice on PCT Protocol After 3 Years on TRT?

[Member456]

Hi everyone,

I’m looking for advice on the best way to structure my PCT after being on TRT for about 3 years, specifically whether enclomiphene should overlap with HCG or only after HCG is discontinued.

Here’s my full background and current plan:

TRT History​

• On TRT for ~3 years total
• Started with a 20-week blast, during which I used HCG
• After that, I cruised at 150 mg/week test-cyp for 3 years
• Used HCG inconsistently during this cruise phase (not continuously)

Wanting To Go Off TRT Now​

• I reintroduced HCG at 1300IU EOD on: 11 December 2025
• My last testosterone cypionate injection was on: 23 December 2025
• I began HCG on 11 December before my last test injection to help reawaken the testes

Current Plan PCT Protocol​

• HCG
  • Dose: 1300 IU EOD
  • Started: December 11
  • Planned duration: 8 weeks
  • Last HCG injection: February 6
• Enclomiphene
  • Dose: 25 mg ED
  • Duration: 50 days
  • Planned start: January 15 (uncertain)

Main Question​

My question is about timing and overlap:

• Should I:
  • Wait until the last HCG injection and then start enclomiphene?
  • or
  • Run enclomiphene together with HCG (overlapping from Jan 15 to Feb 6)?

HCG acts directly on the testes while enclomiphene works centrally via LH/FSH signaling, so I’m unsure whether overlapping them would be synergistic or counterproductive for the best possible outcome of natural testosterone recovery. While some say the synergy is better for testicle size and fertility recovery, others say using them seperately is better for overall HPTA recovery and higher test levels post recovery.

Considerations​

• Waiting too long after the last testosterone cypionate injection before starting enclomiphene could leave me feeling significantly hypogonadal once test clears completely out of my system, and that overlapping HCG and enclomiphene might provide a smoother transition rather than an abrupt drop.
• Using HCG and enclomiphene together may be more effective for sperm production and testicular size recovery compared to strictly sequential use, which might be a valid reason for overlapping them instead.

My Main Goal​

• Restoring fertility parameters as effectively as possible
• Restoring testicular function and size as effectively as possible
• Restoring natural testosterone production as effectively as possible
• Avoid unnecessary suppression or a prolonged “crash” during recovery

Any insight, experience, or reasoning would be greatly appreciated.

In order to help others I will update this thread regularly.

Thanks in advance for the help.

 

[Member456]

Today is 15 January and I’m debating whether I should start enclomiphene now or wait until testosterone is fully out of my system (and HCG as well).

I was running testosterone cypionate, with my last injection on 23 December. Given an ~8-day half-life, that puts me at roughly 17% remaining as of today (~3 weeks later).

I also started HCG on 11 December, so I’ve been on it for about 5 weeks now, with ~3 weeks left to go.

Looking for input on timing enclomiphene — start now vs waiting until exogenous test is fully cleared.

@Nelson Vergel

 

[Member456]

@Nelson Vergel !!

 

[Tnguy]

@Nelson Vergel !!

I actually stopped TRT on December 18, 2025 after 9 yrs. I took hcg 0.5ml twice a week for a few weeks and titrated down my dose and stopped it. I was already taking enclomiphine 3 days a week on MWF. The hcg will help your hand off from TRT to enclomiphine but the reach I did said to start enchlomiphine before or immediately upon stopping trt. Your circulating trt in your blood stream will take many day if not weeks to get out of your system and allow your total testosterone to drop down to a threshold that enclomiphene will actually start stimulating your testicles to wake up. You may experience a very harsh “rock bottom” to be aware of. My total test dropped to 73 while taking 12.5 mg daily for the first couple weeks and we double the dose to 25mg daily and after 3 weeks total t was at 525, free t 85, shbg 40, estradiol 30 and LH and FSH into mid levels. I am getting new labs tomorrow 3/23/2026 to see what all levels have topped out at on 25mg. I was not expecting the physiological and mental test this handoff was going to be like. My doctors really didn’t articulate it very well other than yo say you may have some low T symptoms. This was low life symptoms, zero libido, chemical castration for a few weeks until things came back online. Thank goodness I took hcg for all these years because my system is rebooting well. I must say, i have gained 10 lbs in 3 months during this process, with water bloating and fat around my belly and love handles. I also look crazy inflated. I have worked seriously for 20 years and can’t believe how different I looked and felt in a matter of a month or so. Make sure you keep some open communication with your wife to protect your marriage. It has been rough. I hope you do not have the same symptoms that I have had. Understand that just because your lab values get better and look normal, you may not feel normal or as you think you should. I would wait 6 weeks between labs to give your body time to adjust and possibly the lagging symptoms to settle so you have a better picture of symptoms vs labs to base decisions on. I plan to drop my 25mg daily dose back to 12.5 tomorrow and not draw labs again for 6 weeks. The 25mg enclomiphene dose can suppress estrogen to much and make you feel incredibly flat and emotionless as well cause some botible ED issues. You may be able to have sex but you won’t enjoy it, that type thing. 12.5 mg usually provides the same total test numbers as 25mg with much less estrogen suppression so I am going this helps me feel better, happier, and sexual function resembles my normal. With low estrogen from a SERM or an estrogen blocker like anestrozole you can tank your E and have perfect numbers everywhere else and feel like total crap. I am very sensitive to anestrozole so I figured that is why I am struggling on this higher estrogen blocking effects at 25mg. I am 48 and not planning on any more kids and only went down this habit hole trial to fix a terrible blood donation leading to low ferritin loop that was also making me feel terrible. For years my trt dose was between .06-.08 ml daily subq. This worked great for a long time but last year I made some tweeks and also went thru a breast cancer diagnosis of my wife and I think the stress and distraction lead me to loose track of my levels and they crept up fast. If my hematocrit ferritin had not been in the terrible loop I would not have stopped trt. Moving forward I believe I am going to give my self a shot at 2-6 weeks of a lower dose on Enclomephine and I may actually go back to trt. My blood work profile is perfect. PSA dropped to .78 from 1.30 which was in range but had been slightly rising year to year. All other values to include ferritin and hematocrit where perfect very quickly after stopping trt. So I will have to better manage my microdosing numbers/amount. On .07ml daily subq my total test levels were around 780 and that was my sweet spot. 580 didnt feel like enough and over 800 I started to get higher hemtocit symptoms. So if I return to trt I am going to aim for 700 and see how things level and better manage hydration, rest, and cardio. I mainly did resistance training and sprint interval training but not enough zone 2-3 30 minutes of just cardio work for circulation and heart health despite the weight training that does benefit the heart. If you have more questions or concerns please message me. I noticed there were not as many articles in the forums more recently on enclomiphine. It was a hot topic in 2020 and then died off. I am I tersted if it because guys just didn’t like the result as much as trt. I think I am one of those guys despite how much I would like to think my body naturally can get me the same feeling and physical results. But not everyone has those genetics. I am not sure I can stay the course for months to figure it out. I will be interested if anyone chimes in. Hope some of this helps and best of luck.