shbg

I’ve searched this forum and several others trying to find a situation that matches mine, but I haven’t found anything that really lines up, so I’m posting here hoping someone sees something obvious that I’m missing. I’m a boxer with 15+ years of training. For the last 4 years I’ve been battling...

Hey guys, I just recently got my blood results back and I think I’ve figured out why I’ve been feeling bad. My DHEA is low, while the rest of my bloodwork looks pretty solid. Results: DHEA-S: 4.2 (reference range 5.7–13.4) Testosterone: 41.0 nmol/L (reference range 8.64–29.0) SHBG: 32.5 nmol/L...

I have been hammering this home on the forum over the years! Again the only way to know where your FT truly sits is to have it tested using the most accurate assay the gold standard Equilibrium Dialysis especially in cases of altered SHBG! * This case highlights a critical diagnostic pitfall...

Abstract INTRODUCTION AND OBJECTIVES: Total testosterone (TT) measurement is widely used to diagnose male hypogonadism (MH). However, TT may be normal despite androgen deficiency when sex hormone-binding globulin (SHBG) is elevated, a condition often associated with ageing and chronic...

Hello can I get some help Symptoms from brain fog and tiredness And feeling like a zombie please any guidance is appreciated it

30 years old, been on TRT for a year. Looking for similar experiences. Before starting TRT, my free T levels were around 0.150 nmol/L, I was clearly deficient. Labs: Total T: 20.78 nmol/L Free T: ~0.641 nmol/L SHBG: 10 nmol/L (below range) Estradiol: 63 pmol/L DHT: never tested LH/FSH...

Bright future! Big things coming soon! Yuvna Jain, a Biological Systems Engineering student at Plaksha University, is currently a research intern at Brigham and Women’s Hospital, Harvard Medical School, Boston, through the Khorana Scholars Program. Working in the lab of Dr. Shailendra...

Sorry for the long trainwreck of a post but I have never been so scared in my life as I’ve been the last 2mos. Before that I’d say I barely ever had anxiety at all, about anything. I’m usually the one who likes taking risks and is always level-headed and calm/confident. I think I’ve been messing...

Hey guys, Would appreciate some input on this pattern. I’ve been experiencing ongoing low energy for the past few years — mainly a lack of morning drive and waking up feeling flat or unmotivated. I wouldn’t describe it as depression, but my baseline motivation definitely feels lower than it...

Low SHBG issues dialing in, So I started TRT again after taking a year off from it, pre try my leveled where 402 TT, 9FT, e2 24 had issues with libido , ED and morning wood nonexistant, plus some bad crash when i took proviron a couple times, felt horrendous like low T and low E2, Tried clomid...

I've have a lot of ups and down on this journey but I am settling in at sub Q 80mg weekly, 2x (40mg/40mg). After switching dosing to many times, I have been settled in around 78-80mg for a few months now. I was on 3x a week, split since the summer and after trying 90mg, 84mg, and then 78mg...

High SHBG reducing your free testosterone? This complete guide explains what SHBG is, optimal ranges for men on TRT, and proven ways to lower it. By Nelson Vergel | ExcelMale.com | Updated December 2025 When evaluating testosterone levels, most men focus exclusively on total testosterone—a...

Ive been doing 26-30mg EOD and just have never felt good, especially not when I went up to 30mg. Just felt wired and anxious/depressed. I took 4 days off and felt better and better every day. I then went down to 20mg EOD after the break and slowly started to feel like shit again. To give some...

Hey guys, Looking for some advice on my TRT protocol. I'm 21, had testicular cancer last year (orchiectomy + chemo, now in remission). Been on TRT for about 3 months, trying to dial it in since I'm still having issues. Here's the situation: Complaint: Zero libido, some anhedonia, water...

Complex allosteric mechanism! * The transport of sex steroid hormones in the plasma is largely mediated by sex-hormone binding globulin (SHBG). SHBG is a functional homodimer, meaning it can bind two sex hormones with similar affinities. This binding occurs through a complex allosteric...

ANDREW Y. SUN, MD UROLOGIST 2X Increase of Mean Free Testosterone 30% Reduction of Mean SHBG

* With CLASH-free, we will improve the clinical applicability of free steroid hormone concentrations in patients with specific conditions by using state-of-the-art methods. * Formulas to estimate free steroid hormone concentrations are used instead, but their applicability in many clinical...

Presented by Dr. Steve Winters, Emeritus Professor, Division of Endocrinology and Metabolism Endocrinology Grand Rounds Summary Introduction Sex hormone-binding globulin (SHBG) represents one of the most clinically significant biomarkers in endocrinology, with implications extending far beyond...

We do it big here at Nelson's stomping ground! Dr. Leen Antonio (UZ Leuven)! She has collaborated with the heavyweights in the field Dr. Bhasin and Dr. Jasuja (Brigham and Women's Hospital)), Dr. Fiers and team (UZ Ghent) on research related to free testosterone.

Dr. Handlesman and Dr. Anawalt two highlly respected and well known endos in the field! https://academic.oup.com/jcem/advance-article-abstract/doi/10.1210/clinem/dgaf370/8171633?redirectedFrom=fulltext Abstract: In this debate, two clinicians discuss the merits and demerits of the free...

I’ve covered this issue in many posts, but I thought it would be helpful to put more information in one thread and expand on the topic. TL;DR: Under TRT, free testosterone is proportional to the dose rate and inversely proportional to the metabolic clearance rate. The liver accounts for most of...

Dr. Jasuja and of course Dr. Bhasin! * Participants were identified using the Research Patient Data Registry (RPDR), selecting individuals with SHBG levels exceeding 100 nmol/L. Preliminary analysis revealed that participants with low free testosterone, despite normal or elevated total...

Hello friends, Hope you are well! I am a 33 year old male, height 183cm, weight 95kg with body fat around 20%. Around 10 years ago, I was diagnosed with secondary hypogonadism. My natural T levels were 8 nMol/L and my FHS and LH were low. The main symptom that led me to do the blood...

ASSESSMENT OF MALE ANDROGEN STATUS: A SURVEY ON MEASUREMENT AND REPORTING OF TOTAL TESTOSTERONE, SEX HORMONE-BINDING GLOBULIN AND FREE TESTOSTERONE IN CLINICAL LABORATORIES ACROSS EUROPE N.Narinx, J. A. Nyamaah, K. David, V. Sommers, J. Walravens, T. Fiers, B. Lapauw, B. Decallonne, F...

Good evening from the UK, had my bloods done and it looks like my testosterone is normal but my SHBG/Albumin are through the roof and my Oestradiol/FSH are through the floor, any ideas why this is happening and how I can correct it? I'm 42, 5'10", 12st(76kg), keep in decent shape. My sleep is...

The thread discusses the modulation of circulating free testosterone fraction during Testosterone Replacement Therapy (TRT) and its relationship with other hormones. Here are the main points from the discussion: Free Testosterone Fraction: The thread emphasizes the importance of the free...

Sex hormone-binding globulin (SHBG) is a homodimeric glycoprotein produced by the human liver and secreted into the systemic circulation where it binds with high affinity sex steroids regulating their availability in blood and accessibility to target tissues. Plasma SHBG levels are altered in...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5064763/ "Access of plasma steroids to target tissues and cells While measurements of free steroid concentrations remain the most robust indicator of the biological activities of plasma steroids (Vermeulen et al. 1999), adoption of the free hormone...

Gentlemen, there is a cure for Low SHBG FINALLY. And, It is tangible unlike the "keto diet and fasting". There is a newly approved drug that could easily more than double our SHBG and for many of us would mean a new life and TRT working. The drug is called Rezdiffra (Resmetirom) manufactured by...

Oral T vs Injectable T - Hair Loss I have read that oral T (Jatenzo/Kyzatrex) converts to DHT more than injectable T. Is this true? If so, would that mean that oral T would accelreate hair loss (for those predisposed) faster than injectable T? Or, would the constant higher T/DHT levels with...

https://research.rug.nl/en/publications/novel-techniques-for-the-quantification-of-protein-biomarker-isof PDF (pp.176-199) INTRODUCTION Sex steroids are main drivers of sexual development and play a fundamental role in many physiological processes in both men and women [1,2]. As such...