side effects

Curated by Nelson Vergel | ExcelMale.com | Updated May 2026 Many men on TRT reach a point where their testosterone levels are optimized, blood work looks solid, yet libido and erection quality still fall short of expectations. For those men, PT-141 - also known as bremelanotide - has become...

Hello, I am 60 and went to my doctor because of extreme fatigue, loss of strength, low energy etc. I thought there was something else wrong with me. I do not drink or smoke and eat healthy and I never thought this could happen to me because am also not overweight and exercise regularly. Or at...

* In patients with locally advanced prostate cancer, tE2 was noninferior to LHRH agonists for 3-year metastasis-free survival, with a lower incidence of hot flashes but a higher incidence of gynecomastia. https://www.nejm.org/doi/full/10.1056/NEJMoa2511781?query=featured_home Abstract...

I have ED, which I believe is mostly due to me having no libido/desire for sex. I've used PT 141 a couple of times with great results and very minimal side effects. I've used a 1mg dose and a 2mg dose, with similar results. The "problem" is I continue to have random erections throughout the day...

Hot off the press! 25th Annual Fall Scientific Meeting of SMSNA! Grapevine, Texas! Great presentation! 1:29:40-1:43:30 Conclusions

In this episode, Dr. Brandon & Dr. Morgentaler talk about the off-label use of bremelanotide (Vyleesi/PT-141) in men—its potential benefits for libido/erections, origins, side effects (notably nausea), and how patients often access it via compounding pharmacies. Chapters 00:05 – Dr. Brandon...

I want to start by saying I'm really enjoying the discussions I'm seeing here along with the anecdotes. I believe I've reviewed all of the prior discussions on here regarding pregnenolone but I still have some questions. Does anyone habe any idea why an individual with undetectable...

Newest kid on the block! * The TULSA Procedure is a new solution for men with prostate disease, including prostate cancer and benign prostatic hyperplasia. It’s a minimally invasive procedure that is incision-free, radiation-free, and performed in an outpatient setting. Profound Medical...

https://www.cbc.ca/news/health/topical-finasteride-risks-fda-u-s-1.7530877 Topical finasteride has never been approved by Health Canada

* FDA has become aware of reports of adverse events associated with the use of compounded topical finasteride. There were 32 cases reported to the FDA Adverse Event Reporting System between 2019 and 2024. Absorption of finasteride through the skin into the bloodstream is expected, and the...

Primo combo here would be daily tadalafil + Spontan (Vardenafil) nasal spray! https://thepenisproject.podbean.com/e/192-up-your-nose-and-up-it-goes-spontan-nasal-spray-for-erectile-dysfunction/ Today on the Penis Project Melissa chats to Professor Eric Chung who is recognised as one of...

Chapters 1:13 Dr. Heath's opening remarks 4:20 Prostate cancer statistics 7:49 Clinical states model 9:22 Risk stratification and staging workup 11:26 FDA approved agents 13:55 Androgen pathway 15:33 Androgen deprivation side effects 18:09 Overall survival benefit with intensification 20:16...

THESE DRUGS ARE POTENT ENDOTHELIAL PROTECTORS! CARDIO PROTECTIVE! 26:42-38:02 https://www.excelmale.com/threads/dr-john-mulhall-md-70-of-ed-cases-are-vascular.31524/ * PDE5 inhibitors - how they work, their cardiovascular benefits, and their limitations

Been on for about 10 months and have tried multiple frequencies, administration sites, and dosages. All of these trials were based on the need to control elevated H&H. The one that did the trick in mitigating it was daily subcutaneous injections totaling 70mg/week. Labs for this protocol were...

I have been taking a low dose HCG (200 IU 3x week) for about 3 weeks now. Testosterone and Estradiol levels have not changed during the period, but I have been experiencing noticeable hair loss for the past week. Was anyone with similar side effects to HCG able to stop hair loss while still...

Welcome to another episode of The Gynarchy Podcast! Today, I am delighted to have Dr. Rachel Rubin, a board-certified urologist, fellowship trained sexual medicine specialist, researcher, and director at large for the International Society for the Study of Women’s Sexual Health (ISSWSH), join me...

In this episode of the Dr. Geo Podcast, Dr. Geo sits down with Dr. Xiaosong Meng from UT Southwestern Medical Center to discuss TULSA (Transurethral Ultrasound Ablation), an advanced focal treatment for prostate cancer. They explore how TULSA works, its benefits, and how it compares to other...

So first of all I live in a country where you can buy T everywhere by just walking into any pharmacy. And no MDs here understand hormones. Your on your own here. second I go more from how I feel than blood markers. I did however test total T ongoing to find the proper dosage. But first I wish...

In this episode, urologists Dr. Justin Dubin and Dr. Kevin Chu tackle one of the most common questions surrounding men's sexual health - how to properly use medications like Viagra and Cialis for erectile dysfunction. Many patients express frustration when these medications don't seem to work...

ABSTRACT Medical management of benign prostatic hyperplasia(BPH) has progressed gradually in recent years and remains the starting point for most symptomatic patients seeking treatment. Beyond well-known alpha-blockers and 5-alpha reductase inhibitors, there is growing evidence for the use of...

The goal of erectile dysfunction treatment is patient satisfaction. Because of that, patients choosing their own treatment have a higher chance of better outcomes. We know ourselves the best. So the more we know about each treatment option, the better for us to deal with this issue. In this...

Weighing the possible side effects of prostate cancer treatments while considering various treatment options can be a daunting challenge for men and their loved ones. We are excited to partner with BioProtect for this episode, with our distinguished guest, Dr. Jonathan Tward, a Radiation...

0:48 How should patients weigh new and old treatments? 3:12 What should patients try to keep in mind when deciding on treatments? 4:42 How does prostate cancer "staging" affect treatment? 5:42 How important is it to get a second opinion on treatment? 7:06 Selection of who is going to guide...

ABSTRACT Introduction The specific role of testosterone (T) replacement therapy in patients with late-onset hypogonadism is still conflicting. Several available preparations have been developed to restore either fertility and normal testosterone (T) levels (secondary hypogonadism) or just T...

Hello, I know this has been asked more than once here but I have Only seen conflicting, old information. I am hoping someone can help. i am 33 and have low t. I was on trt but recently was prescribed clomid. The generic version is being discontinued and my insurance doesn’t cover it, so it...

There are some topics here and in other forums (please Google "TRT and ED" on Reddit or other forums) of men complaining about having ED on TRT after being good and dialed for months or even years and suddently developing impotence out of nowhere. Suspects are: estrogen imbalances, low SHBG...

The review discusses novel drugs undergoing clinical trials for treating ED, focusing on their safety, efficacy, and biochemical profiles. The analysis indicates that these drugs show clear effectiveness and safety in treating ED, with varying effects on PDE isoenzyme families. Udenafil, with a...

Hello all, I have been on TRT (150ml of 200mg/ml a week, split into 3 injections) for about two years. Up until now everything was great. About a month ago I noticed every time I injected my blood pressure rose into the 130/140’s and I would be dizzy for a day. Hematocrit came back at 47, I...

As some of you know, I included again into my TRT protocol the HCG at 150IU daily using Pregnyl. I have used the HCG for 10 days straight now, and I’d like to know if you guys think I should wait a bit longer or this call for a dose reduction. I have good side effects but to keep the post...

https://www.mirror.co.uk/news/world-news/supermarket-evacuated-over-fears-highly-30673037.amp Spider venom may be the new Trimix.