Should “Age-Related” Testosterone Deficiency (TD) Be Treated?

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Presentations from the 32nd Annual International Prostate Cancer Update - Grand Rounds in Urology

These lectures were presented during the 32nd Annual International Prostate Cancer Update in March 2022, in Snowbird, Utah.

grandroundsinurology.com

SESSION 2: Androgen Society Presentations (2022)​

 

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Metabolic effects of testosterone in men - ExcelMale - #1 TRT & Testosterone Forum | Expert-Moderated Men's Health Community

The effects of testosterone replacement therapy in men with age-dependent hypogonadism on body composition, and serum levels of leptin, adiponectin, and C-reactive protein Abstract Introduction: Age-related hypogonadism in men leads to abnormal body composition development and...

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Effect of T supplementation on sarcopenic components in middle-aged and elderly men - ExcelMale - #1 TRT & Testosterone Forum | Expert-Moderated Men's Health Community

ABSTRACT The aim of this study was to conduct a systematic review of the literature of randomized controlled trials on the effect of testosterone (T) supplementation compared to the placebo group or lower dose on sarcopenic components (muscle mass, strength, and physical performance) in...

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Does TRT Really Improve Sex Drive and Function in Older Men? - ExcelMale Forum. TRT, Hormones, Peptides, Men’s Health

Controversial aspects of testosterone in the regulation of sexual function in late-onset hypogonadism Abstract Background: Testosterone (T) plays a pivotal role in coordinating a series of psychological, cognitive, and physical events that might (or might not) culminate in male sexual...

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Testosterone and Bone Health in Men - ExcelMale - #1 TRT & Testosterone Forum | Expert-Moderated Men's Health Community

Abstract: Bone fracture due to osteoporosis is an important issue in decreasing the quality of life for elderly men in the current aging society. Thus, osteoporosis and bone fracture prevention is a clinical concern for many clinicians. Moreover, testosterone has an important role in maintaining...

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‘‘Age-Related’’ Low Testosterone Should not Be Treated: CON - ExcelMale - #1 TRT & Testosterone Forum | Expert-Moderated Men's Health Community

Abstract The negative effects of testosterone deficiency (TD) on human health and quality of life are well demonstrated, including signs, symptoms, metabolic syndrome, obesity, and increased mortality. Recently, substantial evidence emerged, demonstrating the benefits of testosterone therapy in...

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Testosterone replacement in aging men - ExcelMale Forum. TRT, Hormones, Peptides, Men’s Health

The deluge of advertisements marketing erectile dysfunction medications and testosterone products has empowered many older men to seek medical help for their sexual and genitourinary problems. As a reflection of this historical transition toward increased attention on men’s sexual health, men’s...

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Late Onset Hypogonadism Update - ExcelMale - #1 TRT & Testosterone Forum | Expert-Moderated Men's Health Community

Late-Onset Hypogonadism - New Point of View (2012) Andrzej Gomuła* The Andropause Institute, Warsaw, Poland 1. Introduction Long-term testosterone deficiency related to age may adversely affect the health, anatomy, and physiology of man. The implementation of testosterone boost therapy...

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TRT for the Treatment of Age-Related Hypogonadism: Risks with Uncertain Benefits - ExcelMale - #1 TRT & Testosterone Forum | Expert-Moderated Men's Health Community

Testosterone Therapy for the Treatment of Age-Related Hypogonadism: Risks with Uncertain Benefits (2021) Christine P. Nguyen, Mark Hirsch, Suresh Kaul, Corinne Woods, and Hylton V. Joffe Abstract Testosterone replacement therapy has been approved in the United States since the 1950s for men...

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Testosterone Improves Metabolic Profiles in Men with Low T - ExcelMale - #1 TRT & Testosterone Forum | Expert-Moderated Men's Health Community

Abstract Purpose Late-onset hypogonadism (LOH) is an age-dependent reduction of testosterone associated with alterations of metabolic profile, including glucose control, insulin sensitivity, and lipid profile. The purpose of this study was to investigate the efficacy of testosterone...

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LOH: Clinical evidence, biological aspects and evolutionary considerations - ExcelMale - #1 TRT & Testosterone Forum | Expert-Moderated Men's Health Community

ABSTRACT The growing life expectancy in modern societies has raised scientific interest in identifying medical interventions to alleviate age-associated pathologies such as vascular calcification, cognitive decline, sarcopenia, osteoporosis, and sexual dysfunction. Although no such single...

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Testosterone and male sexual function - ExcelMale - #1 TRT & Testosterone Forum | Expert-Moderated Men's Health Community

Androgens and male sexual function (2022) Giovanni Corona, MD, Ph.D., Consultant Endocrinologist, Giulia Rastrelli, MD, Ph.D., Associate professor of Endocrinology, Linda Vignozzi, MD, Ph.D., Associate professor of Endocrinology, Mario Maggi, MD, Ph.D., Full professor of Endocrinology Sexual...

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Role of Testosterone in the Elderly - ExcelMale Forum. TRT, Hormones, Peptides, Men’s Health

Abstract: Testosterone is the most important hormone in male health. Aging is characterized by testosterone deficiency due to decreasing testosterone levels associated with low testicular production, genetic factors, adiposity, and illness. Low testosterone levels in men are associated with...

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Impact of low-T and testosterone therapy (TTh) on main health conditions - ExcelMale - #1 TRT & Testosterone Forum | Expert-Moderated Men's Health Community

Morbidity and mortality in men: Role of androgens (2022) Giuseppe Fallara, Edoardo Pozzi, Christian Corsini, Federico Belladelli, Luca Boeri, Paolo Capogrosso, Francesco Montorsi, Andrea Salonia In this narrative review, we provide an overview of the current literature on male hypogonadism and...

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Pre-Testosterone Therapy Checklist - ExcelMale - #1 TRT & Testosterone Forum | Expert-Moderated Men's Health Community

Click here for: PRE-TRT LAB TESTS The Pre-Testosterone Therapy Checklist (2022) Jose M. Flores, MD, MHA, and John P. Mulhall, MD, MSc, FECSM, FACS, FRCSI INTRODUCTION In contemporary practice, there are a myriad of testosterone therapy (TTH) modalities of exogenous TTH in the form of oral...

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Low Testosterone in Men: Recommendations on the diagnosis, treatment and monitoring - ExcelMale - #1 TRT & Testosterone Forum | Expert-Moderated Men's Health Community

ABSTRACT The relative proportional increase of the elderly population within many countries will become one of the most significant social transformations of the twenty-first century and, for the first time in history, persons aged 65 or above outnumbered children under five years of age...

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Testosterone Deficiency in Men - ExcelMale - #1 TRT & Testosterone Forum | Expert-Moderated Men's Health Community

Optimizing Diagnostic Accuracy and Treatment Decisions in Men With Testosterone Deficiency (2021) Shalender Bhasin, MB, BS *, Noelle Ozimek, MSc Abstract Objective: This narrative review offers a guideline-based approach for optimizing diagnostic evaluation and treatment decision-making in...

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APPROACH TO THE DIAGNOSIS AND EVALUATION OF HYPOGONADISM - ExcelMale Forum. TRT, Hormones, Peptides, Men’s Health

Diagnosis and Evaluation of Hypogonadism (2022) Alvin M. Matsumoto, MD INTRODUCTION Over the last 20 years, large database surveys of several countries reported consistent two- to four-fold increases in the rates of testosterone testing and prescriptions from 2000 to 2014.1 Increases in...

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TRT and Cardiovascular Disease - ExcelMale - #1 TRT & Testosterone Forum | Expert-Moderated Men's Health Community

Testosterone replacement therapy and cardiovascular disease (2022) Jeremy M. Auerbach and Mohit Khera The use of testosterone therapy has a complex history of apprehension and questions regarding its safety. Despite an eventual consensus that testosterone therapy was safe and effective...

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TRT and the Prostate - ExcelMale - #1 TRT & Testosterone Forum | Expert-Moderated Men's Health Community

Testosterone Treatment and the Risk of Prostate Adverse Events (2022) Jason A. Levy, DO, MS, Arthur L. Burnett, MD, MBA, Adrian S. Dobs, MD, MHS INTRODUCTION Definition Hypogonadism is a clinical syndrome that results from failure of the testis to produce physiologic concentrations of...

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