TRT pulse dosing

[Mt8space]

Has anyone experimented and had any success with pulsing your testosterone dose.
Example would be every day injections but one day is double the dose? 10mg today but 20mg tomorrow and repeat daily alternating between doses? I imagine the testosterone levels would be similar at end of week, but I need hematocrit and hemoglobin to be more stable as it’s quickly out of range even at 140 a week split evenly every day injections.

 

[madman]

Has anyone experimented and had any success with pulsing your testosterone dose.
Example would be every day injections but one day is double the dose? 10mg today but 20mg tomorrow and repeat daily alternating between doses? I imagine the testosterone levels would be similar at end of week, but I need hematocrit and hemoglobin to be more stable as it’s quickly out of range even at 140 a week split evenly every day injections.

20 mg T daily (140 mg T) week is still a fairly high weekly dose of T and although a frequent injection protocol will have a huge impact on clipping the peak--->trough and result in more stable blood levels throughout the week it can still easily drive up the hematocrit if your steady-state as in 24/7 FT level is too high.

Such dose can easily still have ones steady-state FT level too high!

* While the precise mechanism underlying secondary polycythemia in the setting of TTh is still debated, it is likely that a longer duration of supraphysiological testosterone levels drives erythrocytosis.


It is far from a given that injecting daily will bring down the hematocrit.

As I stated in my reply from another thread.

Yes injecting daily in the hopes of bringing down the hematocrit or estradiol can work for some but it is far from a given as many men still end up running too high a trough/steady-state FT on dailies.

Keep in mind it is not just the high peaks/peak--->trough that drives up the hematocrit.

Running too high a trough/steady-state FT will play a big role here.

Switching from twice-weekly to dailies will clip the peak--->trough and the difference between the peak/trough would be minimal, blood levels will be very stable throughout the week but if you still end up hitting a high steady-state FT it can still have a big impact on elevating the hematocrit let alone estradiol.

Many tend to lower the weekly dose when switching to dailies otherwise they may still end up hitting too high a steady-state FT.

Even though you are not increasing your weekly dose and you will be clipping your peak--->trough, blood levels will be more stable throughout the week the same weekly dose split into dailies may still have your steady-state FT level too high.

The two formulation with the least impact on driving up hematocrit would be nasal T gel (Natesto) or any of the newer oral TU formulations (Jatenzo, Tlando or Kyzatrex).

Thread 'Guidance on the use of oral TU : background, clinical considerations, and best practices'

Dec 20, 2025

When it comes to elevated hematocrit everyone is still so caught up on peak T levels!

As I have been preaching for years on here running too high a trough/steady-state FT will have a big impact here!

* While the precise mechanism underlying secondary polycythemia in the setting of TTh is still debated, it is likely that a longer duration of supraphysiological testosterone levels drives erythrocytosis.








* Testosterone undecanoate (TU), developed in the 1970s, provided a solution by utilizing lymphatic absorption to bypass hepatic metabolism. The...

• madman
• hypogonadism mens health Oral T/kyzatrex
• Replies: 5
• Forum: Testosterone and Men's Health Articles

 

[Vince]

Has anyone experimented and had any success with pulsing your testosterone dose.
Example would be every day injections but one day is double the dose? 10mg today but 20mg tomorrow and repeat daily alternating between doses? I imagine the testosterone levels would be similar at end of week, but I need hematocrit and hemoglobin to be more stable as it’s quickly out of range even at 140 a week split evenly every day injections.

You may want to try a lower dose. You could just inject 12 mg daily and I would add in HCG to keep your testicles full.

 

[Mt8space]

You may want to try a lower dose. You could just inject 12 mg daily and I would add in HCG to keep your testicles full.

How much HCG?

 

[Vince]

How much HCG?

I would start with 250 IU twice a week. I inject 500 IU of HCG every third day. Some members estrogen runs too high on HCG. So it's better to start low and gradually work up.

 

[Mt8space]

20 mg T daily (140 mg T) week is still a fairly high weekly dose of T and although a frequent injection protocol will have a huge impact on clipping the peak--->trough and result in more stable blood levels throughout the week it can still easily drive up the hematocrit if your steady-state as in 24/7 FT level is too high.

Such dose can easily still have ones steady-state FT level too high!

* While the precise mechanism underlying secondary polycythemia in the setting of TTh is still debated, it is likely that a longer duration of supraphysiological testosterone levels drives erythrocytosis.


It is far from a given that injecting daily will bring down the hematocrit.

As I stated in my reply from another thread.

Yes injecting daily in the hopes of bringing down the hematocrit or estradiol can work for some but it is far from a given as many men still end up running too high a trough/steady-state FT on dailies.

Keep in mind it is not just the high peaks/peak--->trough that drives up the hematocrit.

Running too high a trough/steady-state FT will play a big role here.

Switching from twice-weekly to dailies will clip the peak--->trough and the difference between the peak/trough would be minimal, blood levels will be very stable throughout the week but if you still end up hitting a high steady-state FT it can still have a big impact on elevating the hematocrit let alone estradiol.

Many tend to lower the weekly dose when switching to dailies otherwise they may still end up hitting too high a steady-state FT.

Even though you are not increasing your weekly dose and you will be clipping your peak--->trough, blood levels will be more stable throughout the week the same weekly dose split into dailies may still have your steady-state FT level too high.

The two formulation with the least impact on driving up hematocrit would be nasal T gel (Natesto) or any of the newer oral TU formulations (Jatenzo, Tlando or Kyzatrex).

Thread 'Guidance on the use of oral TU : background, clinical considerations, and best practices'

Dec 20, 2025

When it comes to elevated hematocrit everyone is still so caught up on peak T levels!

As I have been preaching for years on here running too high a trough/steady-state FT will have a big impact here!

* While the precise mechanism underlying secondary polycythemia in the setting of TTh is still debated, it is likely that a longer duration of supraphysiological testosterone levels drives erythrocytosis.








* Testosterone undecanoate (TU), developed in the 1970s, provided a solution by utilizing lymphatic absorption to bypass hepatic metabolism. The...

• madman
• hypogonadism mens health Oral T/kyzatrex
• Replies: 5
• Forum: Testosterone and Men's Health Articles

Thx Madman for your sharing this information. I enjoy learning more and appreciate your input.

Any studies or thoughts on twice daily injections for TRT? I am down to 112mg a week and plan to get retested in 6 weeks to see if drop in dose helped. Also went sub-q in stomach area as I was doing shallow IM glute previously. I am doing daily AM injections.

 

[madman]

Thx Madman for your sharing this information. I enjoy learning more and appreciate your input.

Any studies or thoughts on twice daily injections for TRT? I am down to 112mg a week and plan to get retested in 6 weeks to see if drop in dose helped. Also went sub-q in stomach area as I was doing shallow IM glute previously. I am doing daily AM injections.

Sensible move lowering your weekly dose (140--->112 mg T/week) and not dropping it too much off the hop.

Could have easily stuck with IM if you are sticking with a daily injection protocol.

Get labs done 6 weeks in once your new steady-state is achieved so you can see where your trough TT and more importantly FT and estradiol sit.

Even then be prepared for a bumpy ride as it is common for one to. experience ups/downs along the way during the weeks leading up until blood levels stabilize as the body is trying to adjust to the decline in hormones.

Also the first 6 weeks means nothing when looking at the bigger picture here as once your blood levels have stabilized it will still take a few more months for the body to adapt to its new set-point and this is the critical time period when you need to gauge how you truly feel overall regarding relief/improvement of low-T symptoms.

Every protocol needs to be given a fighting chance as in 12 weeks to truly gauge the effectiveness.

Keep in mind it will take time to see your hematocrit come down due to the lifecycle RBC 120 days so where it sits 6 weeks in is not where it will end up 3-6 months later.

Need to be patient here.

Main advantage when it comes to more frequent injections is clipping the peak--->trough and blood levels will be more stable. throughout the week but you still need to be mindful of what trough FT level you are hitting as there is a big difference between one hitting a. high-end/high trough FT 20-25 ng/dL injecting daily vs twice-weekly vs once weekly.

I would say injecting twice-weekly is the most common and would be more advantageous when it comes to peak--->trough and achieving more stable blood levels throughout vs once weekly the week but even then one can easily end up hitting to high a trough FT.

Many men tend to overlook this and are more importantly are caught up on that more T is better mentality nonsense gunning for too high a trough FT level which can easily backfire especially when it comes to hematocrit.

Throw mood and sexual function in there too as you are hammering the s**t out of your CNS and dopamine when you are running too high a trough/steady-state FT.

T is a threshold hormone.

The body was never meant to be amped up on T 24/7 day in and day out.

Best piece of advice here would be trying to find the lowest trough FT level you can run which will allow you to obtain the overall benefits and minimize the sides.

Most men will easily do well hitting a healthy/high trough FT 15-25 ng/dL or the upper 1/3rd.

The only men that would ever need to push their trough TT >1000 ng/dL in order to achieve a high trough FT would be the men with highish/high SHBG.