What are your thoughts on only taking oral TU once a day(AM) instead of BID?

[aj allday]

I am contemplating using higher dosages of Kyzatrex (600 mg or 800mg) only at breakfast. I am hoping this will more closely mimic the body's diurnal rhythm. Has anyone tried this? I am guessing it will cause only one big am spike in t and prevent atrophy as the half life is short. Maybe less overall DHT conversion as their would be less peaks? Also, I believe maybe Maxiumus does this also with their oral t. My ultimate goal is adding muscle as it is something I struggle with (56).

 

[Nelson Vergel]

There is some discussion on taking it with breakfast and lunch (not dinner):

Thread 'Oral TU (Kyzatrex) - Breakfast + Lunch Dosing Protocol/PKs'

Apr 18, 2025

* Just to be clear when it comes to the Breakfast + Lunch Dosing Protocol/PK as Dr. Sun stated: and although this is obviously not real pharmacokinetics I just basically superimposed the two graphs on eacth other and I think that this is roughly what's happening because I've checked labs on hundreds of patients at all different time frames




7:55-13:42

• madman
• hypogonadism men's health Oral Tu/kyzatrex tth
• Replies: 7
• Forum: Testosterone and Men's Health Articles

 

[FunkOdyssey]

I wish they could modify the ester for a curve that drops to baseline at about the 20hr mark.

Cream or testosterone propionate might be what you're looking for here.

 

[aj allday]

I've been on Kyzatrex going on two years. I can not take a high dose due to over stimulation from rapid absorption. So right there, I am not the best reference for your potential needs.

I take only 100mg x 2/day breakfast and lunch, which puts my free T supraphysiological during the peak, but it crashes too far by next morning, so also take 6 mg T cyp every three days to keep the trough off the floor.

I tried 200mg once a day and it was terrible! Awful hyper stimulated during peak and hard crash by mid afternoon.

I wish they could modify the ester for a curve that drops to baseline at about the 20hr mark.

Great response, thank you. I just started and am not sure it is potent enough based on the studies. As a side note, I am at 550/650 naturally, but have osteopenia so adding muscle is my main concern.

 

[aj allday]

Cream or testosterone propionate might be what you're looking for here.

I am interested in cream but the hair loss factor worries me.

 

[SpazTheCat]

I am interested in cream but the hair loss factor worries me.

For what it’s worth, I’ve been on cream for about 4 years and didn’t notice any difference in hair loss. I also just use it once daily and feel much better than using it twice daily.

 

[madman]

I am contemplating using higher dosages of Kyzatrex (600 mg or 800mg) only at breakfast. I am hoping this will more closely mimic the body's diurnal rhythm. Has anyone tried this? I am guessing it will cause only one big am spike in t and prevent atrophy as the half life is short. Maybe less overall DHT conversion as their would be less peaks? Also, I believe maybe Maxiumus does this also with their oral t. My ultimate goal is adding muscle as it is something I struggle with (56).

No need to jump in at 600-800 mg once daily as you may very well be one who can achieve a stellar peak FT on the starting dose or 300-400 mg.

No need to jump in head first and steady-sate will be achieved within a week so you can get your blood work done 7 days in to see where your peak TT and more importantly FT sits on said dose.

Then you can decide if the dose needs to be titrated upwards.

Even then not sure why you are so caught up on achieving a well beyond what would be needed peak as it is short-lived and you are not going to be putting on a lot of muscle dosing oral TU once daily.

Even if you went with the standard BID (am/pm) or Dr. Suns hybrid (am/noon) protocol you would still not be reaping the full anabolic benefits of T as injections will always be KING here as not only can one achieve high/very high or better yet absurdly high FT levels (peak/trough) depending on the dose used but T levels will be high 24/7 steady-state which is ideal for gaining muscle/increasing strength hands down!

Supra-physiologic steady-state as in 24/7 is where it's at!

This is why men abuse T/AAS.

No way oral TU let alone nasal T gel (Natesto) would even cross my mind if the goal was to gain muscle/increase strength.

If your goal was to use the least suppressive formulation then Natesto would take the cake or if anything oral TU would be less suppressive then injections especially dosed once daily!

When it comes to the modality that most closely mimics the natural circadian rhythm of a healthy young male the T-patch (Androderm) applied before bed holds that title!

*Only Androderm®, an evening PA transdermal patch, closely replicates the normal T circadian rhythmicity

Post in thread 'Testosterone: Navigating Options & Implementation in Clinical Practice'

Oct 9, 2023

Dr. Mohit Khera mentions even Natesto, which has an even shorter peak/half-life, activity at the T receptor lasts for many hours after the peak.

Your reply from post #9.

Andrew, Y. Sun, MD, also states 0% cases of erythrocytosis in men taking oral testosterone Kyzatrex.

Wow!



Forget editing your post as I already seen what you originally wrote.

Must have gone over your head.

Again look over the PKs of any of the oral TU formulations.

This is the main reason why they are less prone to driving up hematocrit.

Now if you want to get to the bragging...

• madman

Post in thread 'Novel administration methods for treating low testosterone'

Apr 23, 2023

I think the shorter acting preparations like natesto and the pills should be the new gold standard for trt since they closely mimic natural production. I’m going to try the oral preparations next I think. Maybe that coupled with Gnrh.

When it comes to most closely mimicking the natural 24-hour circadian rhythm of a healthy young male that title would go to the testosterone patch (Androderm).

*Only Androderm®, an evening PA transdermal patch, closely replicates the normal T circadian rhythmicity


Natesto let alone oral TU will never be the gold standard as most are...

• madman

• 

This is key:

(i) elevated and near peak TT level during nighttime sleep, (ii) peak TT level around the time of morning awakening, (iii) moderately elevated TT level during the initial hours of wakefulness, (iv) reduced TT level in the late afternoon, and (v) lowest TT level in the evening. Based upon these criteria, only the Androderm® transdermal patch (Figure 3D), when applied in the evening (∼22:00 h) as recommended, closely mimics the TT circadian rhythm of normal young adult males.

Post in thread 'High testosterone is like … finasteride? Say what!'

Mar 27, 2025

as far as pharmacokinetics, if I remember correctly, scrotal cream applied once per day only is the closet to mimic endogenous T production. Too bad the DHT issue classify it far away from physiologic to me.

No that title would go to the T-patch (Androderm) applied before bed!

This is key:

(i) elevated and near peak TT level during nighttime sleep, (ii) peak TT level around the time of morning awakening, (iii) moderately elevated TT level during the initial hours of wakefulness, (iv) reduced TT level in the late afternoon, and (v) lowest TT level in the evening. Based...

• madman

• 

Thread 'Does Patient-Applied TRT Pose Risk for Blood Pressure Elevation?'

Nov 12, 2022

Does Patient-Applied Testosterone Replacement Therapy Pose Risk for Blood Pressure Elevation? Circadian Medicine Perspectives (2022)
Michael H. Smolensky, Ramon C. Hermida, Linda Sackett-Lundeen, *Ramon G. Hermida-Ayala, and Yong-Jian Geng


ABSTRACT

We reviewed medication package inserts, US Food and Drug Administration (FDA) reports, and journal publications concerning the 10 nonbiosimilar patient-applied (PA) testosterone (T) replacement therapies (TRTs) for intraday serum T patterning and blood pressure (BP) effects. Blood T concentration is circadian...

• madman
• blood pressure hypertension trt
• Replies: 8
• Forum: Testosterone and Men's Health Articles

• 

 

[madman]

I've been on Kyzatrex going on two years. I can not take a high dose due to over stimulation from rapid absorption. So right there, I am not the best reference for your potential needs.

I take only 100mg x 2/day breakfast and lunch, which puts my free T supraphysiological during the peak, but it crashes too far by next morning, so also take 6 mg T cyp every three days to keep the trough off the floor.

I tried 200mg once a day and it was terrible! Awful hyper stimulated during peak and hard crash by mid afternoon.

I wish they could modify the ester for a curve that drops to baseline at about the 20hr mark.

This would defeat the purpose of what makes oral TU unique especially when it comes to sides/overall suppression.

Fairly short-lived daily peak with longer time spent at trough.

Gonna bite my tongue here!

BH next time you are going to delete or have someone delete your thread make sure you give everyone that replied to your thread a heads up!

 

[aj allday]

For what it’s worth, I’ve been on cream for about 4 years and didn’t notice any difference in hair loss. I also just use it once daily and feel much better than using it twice daily.

Thanks for that, it is very encouraging. How many clicks and where do you apply? Is it 20% from Empower?

 

[aj allday]

This would defeat the purpose of what makes oral TU unique especially when it comes to sides/overall suppression.

Fairly short-lived daily peak with longer time spent at trough.

Gonna bite my tongue here!

BH next time you are going to delete or have someone delete your thread make sure you give everyone that replied to your thread a heads up!

Great response as usual-Thank you. Excellent point about Kyzatrex not being anabolic enough. My Doc recommended I give Kyatrex a chance and the use Oxandrolone for the muscle gaining. Very appealing as I could keep my tt at somewhat normal levels (less potential sides) and hopefully still get the anabolic boost from the Oxandrolone.

 

[madman]

Great response as usual-Thank you. Excellent point about Kyzatrex not being anabolic enough. My Doc recommended I give Kyatrex a chance and the use Oxandrolone for the muscle gaining. Very appealing as I could keep my tt at somewhat normal levels (less potential sides) and hopefully still get the anabolic boost from the Oxandrolone.

Hope you understand if you are seeking increased muscle/strength oxo would need to be dosed daily using a high enough dose to take advantage of the anabolic benefits here.

Need to tread lightly when it comes to using any of the 17α-alkylated orals such as stanozolol, oxandrolone, methyltestosterone, methandrostenolone, oxymetholone, and fluoxymesterone as they are notorious for driving down HDL, increasing LDL, stressing the liver and hammering down SHBG.

Even then the dose/duration of use will play a big role.

Also keep in mind use of any AAS will cause suppression of the HPG-axis and oxo is notorious for hammering down SHBG, having a negative effect on lipids and liver enzymes (dose dependant) and it is not a compound you would want to be using long-term in high doses even though it is considered one of the milder c-17 alpha alkylated orals.

Post in thread 'All About Oxandrolone'

Sep 23, 2021

Those wishing to experiment with Oxandrolone can try 10mg (with caffeine which apparently helps absorption) no more than twice a week taken directly before the two hardest workouts of the week. This should give noticeable results over a period of several months with little to no side effects assuming train and diet were resulting in progress before the drug was introduced. IME the dosages generally used are unnecessarily large, and using a dose that can be continued for long periods will give better overall results. Dosing every day will result in the drug being in the body during...

• madman

• 

Thread 'Oxandrolone (Anavar): A systematic review (2025) - 24 studies & over 1,900 patients'

Nov 23, 2025

This review investigates the use of the synthetic steroid oxandrolone across various clinical populations. The review analyzes twenty-four randomized controlled trials to synthesize evidence regarding the safety and effectiveness of oxandrolone for conditions such as severe burns, HIV-associated weight loss, Turner syndrome, and Klinefelter syndrome. Overall, the findings suggest that oxandrolone is associated with improvements in body composition indices and reduced hospitalization time, generally exhibiting a low incidence of adverse effects, though elevated liver...

• madman
• Burn lean mass oxandrolone Pathology
• Replies: 3
• Forum: Clinical Use of Anabolics and Hormones