What is the Function of Sex Hormone Binding Globulin SHBG?

[Nelson Vergel]

Classic and Novel SHBG effects on the Cardiovascular System in Men - ExcelMale - #1 TRT & Testosterone Forum | Expert-Moderated Men's Health Community

In men, 70% of circulating testosterone binds with high affinity to plasma sex hormone-binding globulin (SHBG), which determines its bioavailability in their target cells. In recent years, a growing body of evidence has shown that circulating SHBG not only is a passive carrier for steroid...

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[Nelson Vergel]

SHBG: biomarker and hepatokine? - ExcelMale - #1 TRT & Testosterone Forum | Expert-Moderated Men's Health Community

Over the past decade, there have been important breakthroughs in our understanding of the regulation and function of sex hormone-binding globulin (SHBG). A recent genome-wide association and Mendelian randomization study have provided new insights at the population level. A thorough study of...

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[magnus68]

There's no trouble getting Total T up, its that most of us have to inject EOD. If a low SHBG guy injected E3.5D, his trough would be rather low; i.e., 500s, and it would appear as though Total T is a problem, when it's not. Think of it as how fast T is metabolized, even if that's not totally accurate. Inject EOD and get tested in the 48hr trough and the guy should be fine in regards to Total T.
Low SHBG is not a problem at all, smaller, more frequent injections, if not daily injections, are how it's dealt with. When I was on E3.5D, I was up and down and up and down and up and down, its not a fun ride, as it were. But injecting more often gets the Total T up and keeps it there.

can you inject test cyp every day? Intra? my shgb is very low