Excel Male Men's Health Forum

Shifting the Testosterone Treatment Paradigm with Oral Testosterone (Kyzatrex)

Jun 26

Again you heard it here first! Nelson's domain the one and only! Very informative webinar on the use of the newer oral TU formulations. Testosterone therapy has long been dominated by injectable and topical formulations, but the landscape...

Men's Health Testosterone Testosterone side effects TRT TRT blood tests

Zimislecel: Stem Cell–Derived, Fully Differentiated Islets Cured Type 1 Diabetes?

Jun 24

Type I Diabetes Mellitus is a terrible disease causing premature death and morbidity. Micro and macrovascular damage are the main contributing factors to injury. This video reports on an article published in the NEJM. The treatment seems to work...

Chronic Illnesses Health & Wellness

Postorgasmic Illness Syndrome: An Update

Jun 24

Briefing Document: Postorgasmic Illness Syndrome (POIS) Source: (Zizzo, Sávio, Ramasamy, Lima, 2022) I. Executive Summary Postorgasmic Illness Syndrome (POIS) is a rare and poorly understood condition primarily affecting men, characterized by a...

Men's Health Sex drive

Testosterone Replacement Therapy (TRT) Facts Every Man Should Know

Jun 23

Testosterone Replacement Therapy (TRT) can be life-changing for many men suffering with low testosterone symptoms. However, there are crucial facts that most men are not told by their physicians before they start TRT. Here are the top facts that...

Health & Wellness Hormones Men's Health Testicular Atrophy Testosterone Testosterone side effects TRT Videos

Smoking Cessation's Effects on Male Hormonal Levels

Jun 22

This scientific paper investigates the effects of smoking cessation on hormonal levels in men, specifically focusing on steroid hormones like testosterone, DHEA, DHEAS, cortisol, and sex hormone-binding globulin (SHBG). The researchers aimed to...

Blood Tests Erectile Dysfunction Health & Wellness Men's Health Testosterone Testosterone side effects TRT Weight Loss

Elevated Hematocrit from Testosterone Therapy vs High-Altitude Adaptation: A Comparative Analysis

Jun 22

From this thread: WARNING: Do not believe Internet "gurus" proclaiming no need to manage hematocrit on TRT - Excel Male TRT Forum Underlying Physiological Mechanisms Testosterone Replacement Therapy (TRT) and Erythrocytosis: Exogenous...

Blood Tests Heart Health High Hematocrit Men's Health Testosterone side effects TRT blood tests

Pregnenolone in Men: Help determining proper dosage and frequency

Jun 21

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Hi all, I've been experimenting with pregnenolone for over a year now, with varied success. I seem to get benefits at 100mg (such as higher libido, more pronounced nighttime erections and better sleep); however, I don't get these results...

Blood Tests Erectile Dysfunction Health & Wellness Hormones Men's Health Products Sex drive Sleep Quality Supplements

The hormonal regulation of men’s sexual desire, arousal, and penile erection

Jun 21

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Briefing Document: Hormonal Regulation of Male Sexual Desire, Arousal, and Penile Erection Source Rastrelli, G., Antonio, L., Carrier, S., Isidori, A., & Maggi, M. (2025). The hormonal regulation of men’s sexual desire, arousal, and penile...

Erectile Dysfunction Estradiol Men's Health Sex drive Testosterone Testosterone side effects TRT blood tests

Lipo-C - Who's using / what doses?

Jun 20

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Hey Folks, I'm curious to see who is using Lipo-C, what your dose/injection schedule is, and what your results (subjective or not) are so far. I recently started with Defy. Dr. Saya had no problem adding Lipo-C to my regimen. (I'm dying for...

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Anastrozole - Enduring Side Effects 5 Years Later

Jun 19

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Hello all, I’m 28yo male in the US. When I was in my early 20s, I had a residual puffy nipple from puberty. I was very self conscious about this, being pretty deep in weight lifting, and my primary care physician prescribed an anti-estrogen...

Estradiol estrogen in men Men's Health Testosterone side effects

Enclomiphene restart - how long?

Jun 18

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38M who has been on TRT + HCG for ~5 years or so. I wanted to see if I could restart production with the help of enclomiphene, as prior to TRT I had a great response to clomid but could not handle the estrogen related sides. I started 12.5mg ED...

Clomid (Clomiphene & Enclomiphene) Men's Health

Medications that Can Impair Muscle Mass and Strength Gains from Resistance Training

Jun 18

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Introduction Many common medications – both prescription and over-the-counter – can influence the muscle mass and strength gains achievable through resistance exercise. Some drugs impair or blunt muscle hypertrophy and strength development, while...

Anabolic Agents Men's Health Muscle Gain Supplements

TRT Hormone Predictor Widget

Understanding Your Hormones

Estradiol (E2)

A form of estrogen produced from testosterone. Important for bone health, mood, and libido. Too high can cause side effects; too low can affect well-being.

DHT

Dihydrotestosterone is a potent androgen derived from testosterone. Affects hair growth, prostate health, and masculinization effects.

Free Testosterone

The biologically active form of testosterone not bound to proteins. Directly available for cellular uptake and biological effects.

Scientific Reference

Lakshman KM, Kaplan B, Travison TG, Basaria S, Knapp PE, Singh AB, LaValley MP, Mazer NA, Bhasin S. The effects of injected testosterone dose and age on the conversion of testosterone to estradiol and dihydrotestosterone in young and older men. J Clin Endocrinol Metab. 2010 Aug;95(8):3955-64.

DOI: 10.1210/jc.2010-0102 | PMID: 20534765 | PMCID: PMC2913038