dht

Join us for our 2-year anniversary episode! Host Chase Hendrickson, MD, from Vanderbilt University Medical Center; regular contributor Rich Comi, MD, from Dartmouth Hitchcock Medical Center; and male reproduction expert Mathis Grossman, MD, PhD, FRACP, from the University of Melbourne and Austin...

I have recently resumed using topical DHT. It has been a few years since I have last used it and the concentrations are now higher than before. Naturally, I was curious as to any implications this may have on prostate health. Research has uncovered some fascinating information...

The thread discusses the modulation of circulating free testosterone fraction during Testosterone Replacement Therapy (TRT) and its relationship with other hormones. Here are the main points from the discussion: Free Testosterone Fraction: The thread emphasizes the importance of the free...

Androgens are a key factor in acne pathogenesis. Lawrence Green, MD, FAAD discusses how hormones help drive the skin disease. How DHT and Androgens Drive Acne Formation Androgens are integrally associated with acne development. Acne originates in the sebaceous gland, which is under androgen...

Unraveling the Mysteries of Benign Prostate Hyperplasia: Insights from Recent Research Benign Prostate Hyperplasia (BPH) continues to present challenges in both understanding its underlying mechanisms and effectively treating its symptoms. Recent research, presented in a transcript from a...

Purpose Androgenetic alopecia (AGA) is the most common type of hair loss in humans, affecting self-esteem and emotional well-being. This study aimed to assess the safety and efficacy of VISPOTM, a standardized saw palmetto oil (2–3% β-sitosterol), in subjects with mild-to-moderate AGA...

Studies examining associations of circulating sex steroids with mortality risk in men show inconsistent results for testosterone (T), with limited data for dihydrotestosterone (DHT) and estradiol (E2). We aimed to clarify associations of sex steroids, sex hormone-binding globulin (SHBG), and...

Defy has a topical Dutasteride. Im considering giving it a try, anyone have experience with this? I dont have bad hairloss, just want to be preventative. Dont want to drop DHT systemically.

So I have been doing TRT for 15 years. For the past 6 months I have reduced my levels down to .3ml per week of 200 mg/ml Test Cypionate from Hikma (thru Kroger). The shots are always Subq. (Test results are below) I kept stepping down because of hair loss. I'm just about at 3 months using...

I seem to convert T to DHT. At mild-moderate doses of 100-150mg T cream/day, my DHT levels run around 200. T levels range from 650-800, E2 30, SHBG 30. I have no clinical signs or symptoms to the negative whatsoever. What is the short and long term impact of running such “high” DHT levels? HCt...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016457/ "These analyses were not prespecified and need confirmation in additional studies of other datasets. Our models were modestly predictive, with r-squared values ranging from 0.16 for HDL cholesterol to 0.27 for vBMD, indicating that there...

I started a previous thread to unravel the mystery of why hCG improves libido in some men, which generated some good discussion but didn't reach any firm conclusions: https://www.excelmale.com/forum/threads/libido-hcg-vs-higher-t-e2.25785/ Now comes a youtube video from Cortex Labs that claims...

Hi everyone, I have been following this board for some time now and was looking to get some opinions on my situation. I am 35-year-old male suffering from post-finasteride syndrome for the last 15+ years. My symptoms are mostly sexual: mild ED, decreased EQ and decreased sensitivity. Below are...

Finasteride and dutasteride, known as 5-alpha reductase inhibitors (5ARIs), are used to treat benign prostatic hyperplasia and androgenetic alopecia. These drugs block the conversion of testosterone to dihydrotestosterone, which affects the neuroendocrine system. They have potential applications...

The pharmacological regimen increased E2 levels for more than 24 hours, affecting the HPG axis, LH, FSH, P4, TST, DHT, SHBG, and IGF-1. While E2 had similar effects to longer-term treatments, SHBG levels did not increase. TST and DHT changes could confound the effects of E2. These hormones have...

So my doc let me change my protocol, I dropped down to 12mg a day , and apply 1 click of test cream which is 12.5mg to the scrotum area. My DHT came back way over range, My TT and FT are about the same as doing 14mg daily that I was doing. The only thing is erection quality went down the drain...

https://www.sciencedirect.com/book/9780128216767/human-gonadotropins#book-description Gonadotropins and steroidogenesis (2022) Estrogens and progestogens The sex steroids are androgen, estrogens, and progestogens. They are all made from the root steroid cholesterol (Fig. 14.1). Cholesterol...

Hello, Does anyone know if cialis and metformin stops or makes rogaine/minoxidil less effective for hair regrowth? Metformin decreases pge2 level: https://www.frontiersin.org/articles/10.3389/fonc.2017.00243/full https://www.nicehair.org/increase-scalp-pge2-decrease-pgd2-cure-hair-loss/

I’m seeing a lot more post with people who have test levels above 1000 who feel crappy. Even with everything else in range e2, DHT, prolactin etc. I’ve also have seen post of people almost using microdose amounts and feeling way better. My question is, is this the new thing? Because my doctor...

So I have been feeling pretty crappy lately (down depressed anxious and no libido) and decided to do labs. I had labs done and my t was -1319 E2 sensitive was - 31 Shgb- 42 Free T was 29 But the weirdest one was my dht it came in at 50pg/ml. Which is incredibly low. What makes no sense is I’m on...

Is Pygeum worth experimenting with? Libido is already an issue for me and I've been trying to improve it for ages. Since Pygeum decreases DHT I'm guessing it can have harmful effects on my libido. I did notice great effects from an alpha blocker - Doxazosin. Thoughts on adding Pygeum to the...

Here is an interesting in vivo study with findings suggesting that lower levels of estrogen in the brain correlate to higher performance in varying forms of memory recall in men. @Cataceous @readalot @Nelson Vergel If a man were to experience brain fog and reduced memory recall while on TRT...

Circulating dihydrotestosterone, testosterone, and free testosterone levels and dihydrotestosterone-to-testosterone ratios in healthy women across the menstrual cycle (2022) Grace Huang, M.D, Shalender Bhasin, M.B., B.S., Karol Pencina, Ph.D., Ming Cheng, M.S., and Ravi Jasuja, Ph.D Objective...

From Conception to Adulthood: The Impact of Androgens on Abnormalities of Male Genital Development and Size (2022) Sarah A. Holzman, Carol A. Davis-Dao, and Antoine E. Khoury Abstract Androgens play a critical role in male development starting in utero. In a 46XY male patient, testosterone...

Hi, Firstly to introduce myself I’m 34 years old and have been on TRT now for 1 year at a dosage of 100mg Test E twice weekly. Feeling overall good during this time however my libido and erectile function could be better. Recent bloodwork shows my DHT levels to be slightly below midrange even...

What’s New in Therapy for Male Androgenetic Alopecia? (2022) David Saceda‑Corralo · Miguel Domínguez‑Santas · Sergio Vañó‑Galván · Ramon Grimalt Abstract Male androgenetic alopecia is a common condition and represents a major concern for patients who experience this condition. While there are...

Has it ever really been verified that creatine raises dht? Would've never thought so but seems like my prostate pings me after use now.

I'm interested to hear from men that have tried both injections and cream when it comes to side effects commonly attributed to DHT, like acne and hair loss. It is clear that serum DHT on cream is ridiculously elevated to many multiples of the normal range in almost everyone using it. However...

I was on scrotal cream for a couple of years and had great results. Wonderful labs. Muscles mass, energy, even libido was great. All except my actual erections. I had amazing libido, but when it came time to actually perform, there was a 50/50 chance of it happening, and if it did happen it was...

https://www.thebrighterside.news/post/microrna-can-regrow-90-of-lost-hair-researchers-find

I hope this is the correct forum for this question. I have been trying to find out if there is any information/studies done on the effects of taking turmeric and it possibly lowering/altering your DHT levels? I just started some and I do not want it messing up my TRT that I have been stable on...