gonadotropins

* We studied 394 men aged 22–76 years with primary (n=132), secondary (n=96), or functional (n=166) hypogonadism treated for up to 7 years with T-gel (1–3 actuations/day; n=168), TU 1000 mg intramuscularly every 10–14 weeks (n=142), or hCG 1500 IU subcutaneously twice weekly (n=84). *...

* Despite these limitations, the findings of this review provide valuable guidance for clinical practice. The consistent benefit of combined hCG and FSH therapy in inducing spermatogenesis and achieving pregnancy supports its role as a first-line treatment for men with HH and infertility. Future...

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Male HPG axis Human spermatogenesis requires both FSH and µmolar locally-secreted intratesticular paracrine T - 100X serum concentration is normal - 10-20X serum will do and is achievable with hCG 500 iU 2-3X/week Can't be sustained by µmolar nmolar circulating endocrine T

* In March 2020, Federal law changed so that compounding several types of biological products, including HCG, became illegal.1 After the Biologics License Application (BLA) transition period ended, it became illegal to manufacture or market compounded HCG in the U.S. without a BLA. The FDA and...

* Despite similar effects on serum testosterone and testicular volume, combined hCG/FSH appeared more efficacious than hCG alone at inducing spermatogenesis. Author Block: Christopher Alan Muir, MBBS1, Ting Zhang, PhD2, Veena Jayadev, MBBS2, Ann Conway, MBBS2, David J. Handelsman, MBBS, PhD...

Author Block: BIONA DEVI KONSAM, DM1, Rama Walia2, Sanjay Bhadada, Professor & Head (DM Endocrinology)2, Pinaki Dutta, DM2. 1JNIMS, Imphal, IMPHAL EAST, India, 2PGIMER, Chandigarh, Chandigarh, India. Disclosure Block: B.D. Konsam: None. R. Walia: None. S. Bhadada: None. P. Dutta: None...

* The hCG treatment typically involved Ovitrelle, a single-dose injection pen containing 250 mcg of recombinant hCG, equivalent to 6,500 IU, which could be administered in multiple smaller doses (increments of 10 mcg = 260 IU). The standard treatment protocol consisted of three injections of 520...

https://academic.oup.com/jsm/article/21/Supplement_6/qdae161.205/7916870 Abstract Introduction The management of male infertility, particularly that induced by the use of anabolic androgenic steroids (AAS), presents a significant challenge in andrology and urology. Anabolic steroids are...

Our expert panel from the Desai Sethi Urology Institute explored key topics in male infertility and men’s health, including navigating the fertility journey, conceiving after testosterone therapy, fatherhood post-vasectomy, and optimizing reproductive health. They debunked myths, shared facts...

* Samples of venous blood were obtained from 22 healthy adult males age 19-26 before and after the im injection of testosterone in aqueous suspension (Oreton©). * The administration of the 12.5 and 25.0 mg of testosterone daily was reflected by markedly higher levels of serum testosterone...

In this episode, hosts Dr. Kevin Chu and Dr. Justin Dubin engage in an insightful discussion about the effectiveness of fertility supplements with expert Dr. Kian Asanad, a fellowship-trained men's health urologist at Keck Medicine of USC who specializes in male fertility and reproductive...

* In HH males, the best results in terms of sperm production are achieved with the co-administration of human chorionic gonadotropin (hCG) and FSH [2, 4]. * Intratesticular testosterone (ITT) binds intracellular androgen receptors located on Sertoli cells, stimulating the secretion of...

INTRODUCTION We have the privilege to introduce a groundbreaking advancement in the field of male infertility to the readers of IBJU: the APHRODITE criteria (1), short for “Addressing male Patients with Hypogonadism and/or infeRtility Owing to altereD, Idiopathic TEsticular function.” Named...

This is gold really enjoyed this one! Worthy of a sticky! Spermatogenesis Induction: A Comprehensive Guide to Male Fertility Treatment Professor Dimitrius Goulis delivers an expert overview of when and how to induce spermatogenesis in men with hypogonadism Introduction Male...

Introduction Two primary functions of mature male testis are spermatogenesis and androgen production. Both these functions are under the control of the hypothalamic-pituitary-testicular (HPT) axis. Gonadotropin-releasing hormone (GnRH) secreted from the hypothalamus acts on the pituitary to...

https://academic.oup.com/jsm/article-abstract/21/7/582/7699977 It is 2024. Direct-to-consumer testosterone replacement therapy advertisements on social media are pervasive. Academic and private practice men’s health centers are abundant. At home semen testing and reproductive health...

Dr. Samplaski state-of-the-art lecture @ 79th Annual Meeting of the CUA! Brief Q&A (27:14-36:42) Brief

12:12-21:46 Here is a summary of the "UROwebinar: Male infertility An updated work up" by the European School of Urology in 10 bullet points: Introduction to Webinar: The webinar, led by Mary Dinkan, covers the latest advancements in diagnostics and treatment of male reproductive health...

INTRODUCTION AND OBJECTIVE Human chorionic gonadotropin (hCG) is an exogenous analog of luteinizing hormone (LH). The only FDA-approved indication for males is to treat hypogonadotropic hypogonadism and cryptorchidism. hCG is used off-label to treat other conditions, including hypogonadism with...

1 | INTRODUCTION Gonadotrophin treatment to induce puberty, spermatogenesis, and fertility in men with congenital or acquired gonadotropin deficiency is based on treatment with human chorionic gonadotrophin (hCG), aplacental heterodimeric glycoprotein hormone and natural, long‐acting analog of...

This video discusses the use of gonadotropin therapy in male infants and adolescents with hypogonadism. Dr. Sasha Howard from Queen Mary University of London explains the evidence and best practices for this treatment. She emphasizes the importance of early diagnosis and treatment to improve...

This systematic review aimed to assess the most effective treatment approaches for male infertility caused by the abuse of Anabolic Androgenic Steroids (AAS). The review followed the PRISMA guidelines and included studies that compared various protocols for restoring spermatogenesis in...

Gonadotropin-Releasing Hormone (GnRH) is a peptide controlling reproductive functions. It binds to GNRHR receptors and has diverse effects. GnRH plays a role in infertility, reproductive disorders, assisted reproduction technology, endometrium, ovary, prostate physiology, tumor transformation...

MP79-17 VARIATIONS IN THE RETAIL PRICE OF HUMAN CHORIONIC GONADOTROPIN IN THE UNITED STATES (2023) Jake Miller*, Mitchell OLeary, Douglas Schneider, Charles Loeb, Lawrence Jenkins, Faysal Yafi, Orange, CA INTRODUCTION AND OBJECTIVE Urine-derived human chorionic gonadotropin (HCG) remains a...

Management Outcomes in Males With Hypogonadotropic Hypogonadism Treated With Gonadotropins (2023) Bahaa O. Sahib, Ibrahim H. Hussein, Nassar T. Alibrahim, Abbas A. Mansour Abstract Background Hypogonadotropic hypogonadism is an important cause of male infertility and loss of secondary...

THE AVAILABILITY OF GONADOTROPIN THERAPY FROM FDA-APPROVED PHARMACIES FOR MEN WITH HYPOGONADISM AND INFERTILITY (2023) Benjamin Borgert, MS, MPH, Michael Bacchus, MS, Alexandra Hernandez, MS, Shelby Potts, ARNP, Kevin Campbell, MD, MS Florida State University College of Medicine, University of...

Male infertility and gonadotropin treatment: What can we learn from real-world data? (2022) Sandro C. Esteves, Arnold P.P. Achermann, Manuela Simoni, Daniele Santi, Livio Casarini Abstract Gonadotropin therapy to treat specific male infertility disorders associated with hypogonadotropic...

https://www.sciencedirect.com/book/9780128216767/human-gonadotropins#book-description Gonadotropins and steroidogenesis (2022) Estrogens and progestogens The sex steroids are androgen, estrogens, and progestogens. They are all made from the root steroid cholesterol (Fig. 14.1). Cholesterol...

https://www.sciencedirect.com/book/9780128216767/human-gonadotropins#book-description Function of gonadotropin releasing hormone and inhibin (2022) Marja Brolinson, Ariel Dunn, Joshua Morris, and Micah Hill Gonadotropin-releasing hormone Neuroanatomy The hypothalamus is located at the...