Testosterone treatment for men who want to preserve fertility

madman · Sep 24, 2026

In this episode, Dr. Brandon & Dr. Morgentaler talk about testosterone treatment for men who want to preserve fertility, including Clomid, hCG, and enclomiphene. They also take a closer look at whether exercise actually increases testosterone, what the research shows about short-term changes after different types of exercise, and whether working out is an effective way to naturally raise testosterone levels.

Timestamps

00:00 TRT and Preserving Fertility
02:00 Using hCG With Testosterone
04:00 Clomid for Fertility and Low Testosterone
07:00 Why Clomid May Not Improve Symptoms
12:00 What Is Enclomiphene?

madman · Sep 24, 2026

Thread 'Fertility maintenance or restoration in men before, during, and after TRT or AAS'

Sep 25, 2022

Fertility Preservation in Hypogonadal Men (2018)
Robert J. Carrasquillo and Ranjith Ramasamy

Introduction

Testicular failure is defined as the impairment or loss of both the endocrine functions of the testis (production of testosterone, or T) and exocrine function (production of spermatozoa). Testicular failure can result from the pathology of the testis itself or disorder at any point in the hypothalamic-pituitary-gonadal axis. Primary testicular failure is characterized by normal/low T in the presence of the elevated follicle-stimulating hormone...

madman · Sep 24, 2026

Thread 'Pros and cons of using TRT vs HCG for treatment low-t symptoms'

Dec 15, 2020

Human chorionic gonadotropin treatment: a viable option for management of secondary hypogonadism and male infertility (2020)
Julius Fink, Brad J. Schoenfeld, Anthony C. Hackney, Takahiro Maekawa & Shigeo Horie

Abstract

Introduction: Low testosterone and its symptoms is a condition affecting many males with severe repercussions on health. Testosterone affects metabolism, bones, joints and ligaments, the cardiovascular system, liver, sexual functions, muscle mass, and the nervous system. Nowadays, due to recent research showing the benefits of testosterone replacement...

madman · Sep 24, 2026

Thread 'Enclomiphene Explained: Is It Better Than TRT?'

Jun 10, 2026

19:11 Why Enclomiphene Is So Unpredictable

* the response is widely variable!

Enclomiphene has quietly become one of the most prescribed men's health medications in America.

It's marketed as the perfect alternative to testosterone replacement therapy (TRT): an oral medication that increases testosterone, preserves fertility, and avoids shutting down your natural hormone production.

But there's one major problem...

It never received FDA approval.

So why are thousands of men taking it every day?

As a board-certified urologist and...

madman · Sep 25, 2026

redigaffi said:
Well, testosterone doesn't kill your fertility, it just pauses it while you're on test, it shut not shutdown your fertility permanently, this was already studies in 2 massive Chinese studies, over 6k men on test for years, 99% recovered their fertility. So test actually acts as a anti-conceptive + the upside of better mood energy drive etc.

Take home-point!

*Testosterone is useful as a contraceptive in human males; however, a regimen with 100% effectiveness has remained elusive.

Post in thread 'TRT used as birth control?'

Jan 24, 2024

wig surf said:
Hi everyone,

I was thinking...If TRT stops the production of sperm, is it possible to use TRT as birth control?
I take 20mg, subq, six days a week, 120mg total a week) and I'm 51 years old.
It's a crazy question, but something I was thinking about.
Thank you all!!

Take home-point!

*Testosterone is useful as a contraceptive in human males; however, a regimen with 100% effectiveness has remained elusive.

*The second WHO study examined the fertility of both the men who became azoospermic and the men who achieved severe oligospermia on the TE regimen...

Last, it is important to consider ethnic differences in interpreting the results of contraceptive trials. For unknown reasons, volunteers in Asia were more susceptible to the steroid suppression of spermatogenesis than were men studied in Europe, North America, and Australia (Handelsman et al, 1995). This difference is not solely a function of body mass and may point to either increased sensitivity to lowered FSH and LH levels, or to a decreased conversion of testosterone to DHT in the testis by differing isoforms of 5~-reductase (Anderson et al, 1996). While the mechanism remains to be elucidated, these differences are important in interpreting the results of various clinical trials and make extrapolation of the data to different populations difficult.

Post in thread 'Women’s Birth Control vs TRT as Contraceptives and Potential Infertility'

Jul 10, 2022

The use of testosterone as a male contraceptive (1998)
JOHN K. AMORY MD
WILLIAM J. BREMNER MD, Ph.D.

Testosterone functions as a contraceptive by suppressing the secretion of the pituitary gonadotropins luteinizing hormone and follicle-stimulating hormone. Low levels of these hormones decrease endogenous testosterone secretion from the testis and deprive developing sperm of the signals required for normal maturation. Interference with sperm maturation causes a decline in sperm production and can lead to reversible infertility in men, raising the possibility that testosterone...