testosterone

* Esterification of testosterone increases its lipophilicity and enables its incorporation into oil-based vehicles to form a depot after injection. The duration of exposure depends not exclusively on the systemic half-life of free testosterone but also on release of the ester from the depot, its...

***Long post incoming.*** I'm interested in who may have had any genetic testing done and if it ultimately led to discovering the "optimal" protocol, whatever that may be. I'm not a fan of the term, but it probably best describes things at this point. TRT prescribed by my PCP for two years...

* Even at female doses, safety data stop at about two years. At male-range levels there is not a single safety trial. Nobody selling a woman a 500 can tell her what it does to her heart or her breasts over ten years. * A woman’s endocrine system is more delicately tuned than the finest Swiss...

I am 49 years old, from the UK, been injection Testosterone Enanthate for over 2 years for gym/muscle building purposes, however recently my blood pressure readings are very high, which is an obvious risk, so I have reduced the dose down to half a ml per week. However, the latest issue is after...

8th Annual Meeting of the Androgen Society 2026 presentations from the top experts in the field! Matthew Budoff Manopause?! https://www.excelmale.com/threads/testosterone-and-cardiovascular-risk-the-traverse-trial-and-results-from-the-new-fda-label-change.32221/...

8th Annual Meeting of the Androgen Society 2026 presentations from the top experts in the field! Dr. Michael Zitzmann Target organs of testosterone and its metabolites The Bifurcation of Testosterone: Amplification vs Aromatization The 5a-Reductase Distribution Map...

General Practitioner Consensus Update Why a GP Consensus Project? Goal Participants/authors The Process 2-Day Consensus Meeting

In this episode, Dr. Brandon & Dr. Morgentaler talk about why low testosterone can be overlooked in men experiencing fatigue, reduced stamina, and other changes often attributed to aging. They also discuss new research on testosterone therapy for women, why its benefits may extend beyond...

https://onlinelibrary.wiley.com/doi/10.1111/andr.70393 Table 1. Serum TT and lipids at baseline and final assessment in the total cohort stratified by TU and statin treatment. Table. 2 Lipid values at baseline and follow-up (24. 48, 72 and 96 months) in men with a follow-up duration...

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* Androgens play a central role in the development of acne vulgaris (acne). Testosterone and its more potent metabolite, dihydrotestosterone (DHT), bind to androgen receptors in sebocytes [1,2]. They activate sebaceous gland activity, inducing a significant increase of sebum production with a...

Testosterone influences far more than just libido and muscle growth: In this episode, Dr. Jonathan Apasu speaks with Prof. Farid Saad about the crucial role of testosterone in metabolism, insulin resistance, prediabetes, diabetes, and obesity. Together, they explain why testosterone deficiency...

* Dr Saad says: “Long-term testosterone therapy in hypogonadal men resulted in profound and sustained in weight loss which may have contributed to reductions in mortality and cardiovascular events. Untreated men with hypogonadism gained weight.” * Dr Saad says: “Long-term testosterone therapy...

Dr. Eisenberg is a board certified urologist and Professor of Urology at Stanford University. He also leads Stanford's Male Reproductive Medicine and Surgery Program. He specializes in men’s health, testosterone, fertility, and sexual dysfunction.He will also explain why reproductive health is...

https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1903508/full The current evidence does not support claims that fenugreek can reliably or clinically meaningfully increase testosterone (7–9). For users and clinicians, the most appropriate summary is that randomized...

https://www.urologytimes.com/view/experts-review-evidence-on-testosterone-and-prostate-cancer Abraham Morgentaler, MD, reviews evidence showing no association between testosterone therapy and prostate cancer risk and explains the saturation model of androgen action.

@ 100mg per week spread over daily injections = 500ish total; free = 65; SHGB = 23 @ 125mg per week spread over daily injections = 650ish total; free = 117; SHBG = 21 @ 200mg per week spread over daily injections = 1300ish total; free = 275; SHBG = 17 At 200 per week my hematocrit and...

19:43 What an 'optimal' testosterone level really is Dr. Mark Gordon * Optimal health is between the 50th and 75th percentile of the range The average man today is walking around with meaningfully less testosterone than his grandfather had at the same age — and the fix the military is...

* This review integrates evidence across diagnostic, therapeutic, and psychosocial domains to clarify what is well supported, what remains provisional, and where the principal contradictions in the literature lie, and it proposes methodologically robust priorities for future research, including...

https://www.penguinrandomhouse.com/books/804404/the-sex-factor-by-mohit-khera-md/ A leading sexual health physician introduces the groundbreaking concept that your sexual wellness may be the single most overlooked predictor of how well—and fully—you live, with a science-backed plan to maintain...

* Dr. Brannigan will explore what every man should know about fertility, including when to seek an evaluation, the role of semen analysis, hormonal testing, genetic factors, and common medical conditions that can impact sperm production and reproductive potential. Dr. Brannigan also discusses...

Learning Objectives HPG Axis Physiology Key TTh Takeaways https://www.adventhealth.com/institutes/research/team/john-tillet-md-1939

Dr. Tobias Kohler * There T level at that point when they are healthy is a very important number. Most of the time it is going to be 500 or so, right? There are some published T levels per decade of life and it does go down. It's pretty rare to get above 1000 naturally considering that as a...

https://www.dha.mil/HHPO The Department remains focused on building and maintaining a ready, lethal fighting force prepared to dominate the battlefield and achieve peace through strength. In his July 15, 2026, memorandum, "Health and Human Performance Optimization to Enhance Military...

https://www.dermatologytimes.com/view/early-recognition-and-psychosocial-impact-in-male-pattern-hair-loss In this first episode, Joshua Zeichner, MD, shares how to spot early male pattern thinning, why it affects confidence, and which proven treatments beat social media hype.

https://www.dermatologytimes.com/view/how-emerging-androgenetic-alopecia-therapies-target-dht-at-the-scalp-level New hair-loss therapies aim to block DHT at follicles, using targeted scalp delivery to reduce systemic side effects and improve male pattern baldness outcomes.

https://www.dermatologytimes.com/view/clascoterone-5-topical-solution-shows-long-term-promise-for-male-pattern-hair-loss Joshua Zeichner, MD, presents phase 3 results showing topical clascoterone 5% stays well tolerated for 12 months and boosts hair density, signaling a new DHT-blocking option.

In this Dermatology Times Expert Perspectives video series, Joshua Zeichner, MD, associate professor of dermatology at Mount Sinai Hospital in New York City, breaks down the key aspects of managing androgenetic alopecia (male pattern hair loss).Zeichner discusses: • Biological Mechanisms: How...

32:00-44:15 Case: 54-Year-Old Man with Vaculogenic ED Case Study: Body Composition Transformation THE EFFECTS OF COMBINED THERAPY ON HORMONAL AND METABOLIC PERFORMANCE DATA-DRIVEN INSIGHTS: QUANTITATIVE BIOMARKER CHANGES...

In this episode, Dr. Brandon & Dr. Morgentaler talk about testosterone treatment for men who want to preserve fertility, including Clomid, hCG, and enclomiphene. They also take a closer look at whether exercise actually increases testosterone, what the research shows about short-term changes...

Educational Objectives In this activity, experts in prostate cancer discuss cardiovascular risk in patients receiving androgen-deprivation therapy (ADT). Upon completion of this activity, participants should be better able to: Evaluate the impacts of prostate cancer and ADT on...