testosterone

  1. madman

    Low Intensity Pulsed Ultrasound Therapy (LIPUS) on Leydig Cell Function: LIPUS holds potential as a physiologic therapy for hypogonadism

    This is wild! Low-intensity Pulsed Ultrasound Enhancement of Testosterone Production https://patents.justia.com/patent/20230249005 https://journals.lww.com/ajandrology/fulltext/2021/23060/low_intensity_pulsed_ultrasound_stimulates.9.aspx
  2. madman

    PSA Testing & Prostate Cancer | NEJM Study: 23-Year Follow-up

    Chapters 1:18 What are the implications of the NEJM's new paper on PSA? 5:28 At what age should most men be getting their PSA checked? 7:56 What is the usual "next step" following a high PSA reading? 10:52 What exactly does a high PSA signify? Does it always mean cancer? 14:24 Alex's conclusions
  3. madman

    Testosterone’s Schedule III Status The Evolving U.S. Regulatory Landscape

    All those so called gurus polluting social media and the half-wits pushing that more T is better mentality bull*** stinkin up those so called men's health/HRT forums! * At the same time, the non-medical environment has evolved, with online marketplaces, informal supply chains, and...
  4. madman

    Prostate Health, PSA Levels & Manhood

    * With more than 40 years of experience, Dr. Burnett has helped shape modern men’s health, pioneering nerve-sparing prostate surgery, advancing nitric oxide research that paved the way for treatments like Viagra, and mentoring physicians around the world...
  5. madman

    How to Keep Strong Erections for Life – Science-Based Advice from a Men’s Health Doctor Specialist

    Dr. Allaire breaks this down! * protecting your erection is protecting your health Eric Allaire Andropause is often presented as the male equivalent of menopause — but this idea is misleading. In this video, I explain why andropause is largely a myth, how testosterone really works...
  6. madman

    FDA Guidance on Development Pathway for Women’s T-Therapy and New Evidence of a Reduced Risk of Breast Cancer Cell Proliferation for AVA-291(d3-T)

    * “d3-T is a novel, structurally identical form of testosterone where select hydrogen molecules have been substituted with deuterium. This small change creates a significant breakthrough.” * AVA-291 is a “next-generation testosterone designed to retain [testosterone]’s androgen activity while...
  7. madman

    Testosterone in women why the UK is falling behind

    In this episode, Dr Louise Newson is joined by urologist and sexual medicine specialist Prof Mohit Khera to talk about testosterone in women and why it remains one of the most misunderstood and underused hormones in medicine. Crucially, this conversation goes far beyond libido. This is a...
  8. A

    Experiences with Testosterone Replacement Therapy in Men: Benefits and Side Effects?

    For men on testosterone replacement therapy, what benefits and side effects have you personally experienced, and how long did it take to notice changes?
  9. madman

    Testosterone’s diverse actions and its critical role as a metabolic messenger

    * The findings from TTrials, TRAVERSE, T4DM and other recent studies have provided high-quality evidence of the metabolic benefits and low risk of serious adverse events associated with testosterone therapy. Reflecting this new evidence, the FDA revised its black box warning regarding...
  10. madman

    The Real Reason Your Erections Are Getting Worse With Age

    Dr. Anand Patel is a GMC-registered GP and one of the UK's leading experts in men's health, specialising in healthy sexual function, testosterone deficiency, and male fertility. Studies are showing that men are dissatisfied with their penis size and commonly experiencing a wide array of sexual...
  11. madman

    Saving Marriages & Bedroom Comebacks: Midlife Women on Testosterone

    Think testosterone is just a male hormone? Think again. In this game-changing conversation, Shalin Shah, CEO of Marius Pharmaceuticals, debunks a major myth in women’s health. Spoiler alert: women have more testosterone than estrogen, and when those levels drop during perimenopause and...
  12. madman

    The Changes Women’s Health Cannot Afford to Delay

    https://kellycaspersonmd.substack.com/p/2026-goals KELLY CASPERSON, MD DEC 29, 2025 The past decade (or 2025 for that matter) has shown that progress in women’s health does not result from being polite, patient, or quiet. It advances when individuals speak uncomfortable truths openly and...
  13. madman

    The Role of Estrogen and Testosterone in Determining Heart, Lung, and Brain Regulation in Humans

    * The investigators plan to explore the direct role of these sex-specific hormones in regulating blood flow to the brain by blocking hormone production in healthy males and females and giving back testosterone and estrogen, respectively. The investigators will then conduct a range of tests to...
  14. madman

    Understanding Polycythemia

    Understanding Polycythemia
  15. madman

    Could Testosterone Therapy Protect Against Developing Prostate Cancer?

    In this episode, Dr. Brandon and Dr. Morgentaler talk about how emerging research suggests testosterone therapy may not only be safe but could actually help protect against aggressive prostate cancer, while also touching on practical approaches to maintaining sexual connection at midlife...
  16. madman

    Request for Information: FDA Expert Panel on Testosterone Replacement Therapy for Men (2025)

    The FDA encourages the public to comment in docket FDA-2025-N-6743 Expert Panel on Testosterone Replacement Therapy for Men. https://www.federalregister.gov/public-inspection/2025-22466/request-for-information-expert-panel-on-testosterone-replacement-therapy-for-men An unpublished Notice by...
  17. Seagal

    Feminism and male testosterone

    Something is happening to men, and no one is talking about it. Child attachment and parenting expert Erica Komisar reveals how modern society is rapidly stripping men of their traditional roles, leaving many feeling lost, directionless, and disconnected from both their families and their...
  18. madman

    Testosterone replacement therapy following definitive treatment for prostate cancer: a scoping review of safety and efficacy

    Testosterone Saturation Model https://www.nature.com/articles/s41443-025-01206-3 Abstract Testosterone replacement therapy (TRT) remains controversial in men with a history of prostate cancer due to historical concerns regarding oncologic safety. This scoping review aimed to...
  19. madman

    The Truth About Men’s Health: Testosterone, Peptides, Fertility, and the Hidden Dangers of Nicotine Pouches

    In this episode, Dr. Jesse Mills tackles pressing issues surrounding men's health, from the effects of nicotine pouches to the latest in genetic therapy. They discover the role of peptides, explore options for penile health, and face the stigma that often hinders open discussions. The hosts also...
  20. madman

    Optum Rx removes reauthorizations from an additional 40 drugs including Testosterone and knee osteoarthritis injectables

    https://www.managedhealthcareexecutive.com/view/optum-rx-removes-reauthorizations-from-an-additional-40-drugs Beginning in January 2026, Optum Rx is removing reauthorizations for two new drug classes: hormone therapies and knee osteoarthritis injectables. Beginning Jan. 1, 2026, Optum Rx, the...
  21. madman

    The Truth About Menopause Everyone Gets Wrong

    Dr. Davis cutting deep here! 27:30 HRT loses its black box warning 29:29 The harm of over prescribing and big dose HRT There is a lot we don’t know about the menopause. It’s a stage of life that can be difficult to navigate for many women - especially since the advice online is all over...
  22. madman

    Menopause, Hormones, and Mental Health: Why HRT Could Be the Lifeline Women Need in Midlife

    * These effects can be life-altering and can lead to social withdrawal, relationship strain and reduced capacity to work. With key neurotransmitter systems including serotonin, allopregnanolone and gamma-aminobutyric acid (GABA) being modulated by fluctuating levels of oestradiol, progesterone...
  23. madman

    Women Need Testosterone Too: The Research No One Talks About

    Testosterone for women is one of the most confusing and misunderstood topics in women’s health. In this episode, Dr. Heather Hirsch and Dr. Kelly Casperson explain why women need testosterone, the science behind female testosterone levels, and how testosterone dosing for women actually works. We...
  24. madman

    Testosterone Therapy for Women | Everything You Need to Know (Fix or Hype?)

    In this episode, Dr. Morgentaler and Dr. Brandon talk about the hype around testosterone for women, debunking exaggerated claims, and bringing a grounded, therapist-friendly perspective on how hormone therapy can genuinely improve libido, mood, and quality of life—when used safely and...
  25. O

    Trouble Finishing (GLP-1 & TRT protocol discussion)

    Newly joined member here but have been lurking for 6mo learning and absorbing as much as I can here. Appreciate what an incredible resource this site is and the members contributing. I fell into the trap of eating poorly, drinking often, and spiraling my weight out of control in the last few...
  26. madman

    TESTOSTERONE: A SAFETY UPDATE 2025

    Professor Michael Zitzmann We also know hematocrit can be increased by testosterone preparations. It depends on the preparation, and we think that there is data that shows that the threshold of 52-54% should not be surpassed, and men should be controlled for the hematocrit especially in the...
  27. madman

    Characterization of Leydig Cell Dysfunction in Previous Illicit Androgen Users

    * Previous illicit androgen users exhibited decreased Leydig cell capacity 2 years after androgen cessation, which potentially influences erectile function https://academic.oup.com/jcem/article-abstract/110/11/e3709/8063344?redirectedFrom=fulltext Abstract Background and Objectives A few...
  28. madman

    Marius Pharmaceuticals Leads Effort to Redefine Women’s Health Through Testosterone Research

    * The newly formed all-female advisory board will provide clinical expertise, advocacy, and strategic guidance as Marius broadens its research and development in female hormone health...
  29. madman

    Testosterone levels decline with age, not menopause, despite what you’ve heard

    Researchers proposed the idea of an “testosterone deficiency syndrome” in menopausal women more than 20 years ago. This was before testosterone had been measured across women’s lifespans and before robust studies of the relationships between blood testosterone levels and specific symptoms. Our...
  30. madman

    Medherant Announces Positive Results for Initial Phase 1 Clinical Trial of Testosterone Patch for Women

    * Medherant’s patch could become the first-in-class testosterone patch developed specifically for women.  Built on the company’s proprietary TEPI Patch technology, it provides exceptional adhesion, ensuring reliable and comfortable wear throughout daily activities.  * David Haddleton, Chief...
  31. madman

    TRT, Peptides & Fertility: A Deep Dive With Dr. Larry Lipshultz

    Step into the origins of modern men’s health and testosterone therapy with Dr. Alex Tatem as he sits down with his mentor, Dr. Larry Lipshultz — the pioneer behind male fertility surgery, testosterone research, and advanced hormone therapy. In this powerful conversation, they discuss: * How...
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