testosterone

  1. madman

    Testosterone replacement therapy following definitive treatment for prostate cancer: a scoping review of safety and efficacy

    Testosterone Saturation Model https://www.nature.com/articles/s41443-025-01206-3 Abstract Testosterone replacement therapy (TRT) remains controversial in men with a history of prostate cancer due to historical concerns regarding oncologic safety. This scoping review aimed to...
  2. madman

    The Truth About Men’s Health: Testosterone, Peptides, Fertility, and the Hidden Dangers of Nicotine Pouches

    In this episode, Dr. Jesse Mills tackles pressing issues surrounding men's health, from the effects of nicotine pouches to the latest in genetic therapy. They discover the role of peptides, explore options for penile health, and face the stigma that often hinders open discussions. The hosts also...
  3. madman

    Optum Rx removes reauthorizations from an additional 40 drugs including Testosterone and knee osteoarthritis injectables

    https://www.managedhealthcareexecutive.com/view/optum-rx-removes-reauthorizations-from-an-additional-40-drugs Beginning in January 2026, Optum Rx is removing reauthorizations for two new drug classes: hormone therapies and knee osteoarthritis injectables. Beginning Jan. 1, 2026, Optum Rx, the...
  4. madman

    The Truth About Menopause Everyone Gets Wrong

    Dr. Davis cutting deep here! 27:30 HRT loses its black box warning 29:29 The harm of over prescribing and big dose HRT There is a lot we don’t know about the menopause. It’s a stage of life that can be difficult to navigate for many women - especially since the advice online is all over...
  5. madman

    Menopause, Hormones, and Mental Health: Why HRT Could Be the Lifeline Women Need in Midlife

    * These effects can be life-altering and can lead to social withdrawal, relationship strain and reduced capacity to work. With key neurotransmitter systems including serotonin, allopregnanolone and gamma-aminobutyric acid (GABA) being modulated by fluctuating levels of oestradiol, progesterone...
  6. madman

    Women Need Testosterone Too: The Research No One Talks About

    Testosterone for women is one of the most confusing and misunderstood topics in women’s health. In this episode, Dr. Heather Hirsch and Dr. Kelly Casperson explain why women need testosterone, the science behind female testosterone levels, and how testosterone dosing for women actually works. We...
  7. madman

    Testosterone Therapy for Women | Everything You Need to Know (Fix or Hype?)

    In this episode, Dr. Morgentaler and Dr. Brandon talk about the hype around testosterone for women, debunking exaggerated claims, and bringing a grounded, therapist-friendly perspective on how hormone therapy can genuinely improve libido, mood, and quality of life—when used safely and...
  8. O

    Trouble Finishing (GLP-1 & TRT protocol discussion)

    Newly joined member here but have been lurking for 6mo learning and absorbing as much as I can here. Appreciate what an incredible resource this site is and the members contributing. I fell into the trap of eating poorly, drinking often, and spiraling my weight out of control in the last few...
  9. madman

    TESTOSTERONE: A SAFETY UPDATE 2025

    Professor Michael Zitzmann We also know hematocrit can be increased by testosterone preparations. It depends on the preparation, and we think that there is data that shows that the threshold of 52-54% should not be surpassed, and men should be controlled for the hematocrit especially in the...
  10. madman

    Characterization of Leydig Cell Dysfunction in Previous Illicit Androgen Users

    * Previous illicit androgen users exhibited decreased Leydig cell capacity 2 years after androgen cessation, which potentially influences erectile function https://academic.oup.com/jcem/article-abstract/110/11/e3709/8063344?redirectedFrom=fulltext Abstract Background and Objectives A few...
  11. madman

    Marius Pharmaceuticals Leads Effort to Redefine Women’s Health Through Testosterone Research

    * The newly formed all-female advisory board will provide clinical expertise, advocacy, and strategic guidance as Marius broadens its research and development in female hormone health...
  12. madman

    Testosterone levels decline with age, not menopause, despite what you’ve heard

    Researchers proposed the idea of an “testosterone deficiency syndrome” in menopausal women more than 20 years ago. This was before testosterone had been measured across women’s lifespans and before robust studies of the relationships between blood testosterone levels and specific symptoms. Our...
  13. madman

    Medherant Announces Positive Results for Initial Phase 1 Clinical Trial of Testosterone Patch for Women

    * Medherant’s patch could become the first-in-class testosterone patch developed specifically for women.  Built on the company’s proprietary TEPI Patch technology, it provides exceptional adhesion, ensuring reliable and comfortable wear throughout daily activities.  * David Haddleton, Chief...
  14. madman

    TRT, Peptides & Fertility: A Deep Dive With Dr. Larry Lipshultz

    Step into the origins of modern men’s health and testosterone therapy with Dr. Alex Tatem as he sits down with his mentor, Dr. Larry Lipshultz — the pioneer behind male fertility surgery, testosterone research, and advanced hormone therapy. In this powerful conversation, they discuss: * How...
  15. madman

    Prostate Cancer What's new and What's coming

    Prostate Cancer What's new and What's coming by Dr. Fred Saad, CQ, MD, FRCS, FCAHS, Professor and Chairman of the Department of Surgery at the University de Montreal, Holder of the Raymond Garneau Chair in Prostate Cancer Research, Director of GU Oncology and Clinical Research as well as the...
  16. madman

    Testosterone and Fertility - Lifestyle Modifications to Raise Endogenous Testosterone

    Str8 from the master blaster! Dr. Lipshultz! Summary of Clinical Practice Implementation Life-Style Changes to Increase T
  17. madman

    Can You Take Testosterone and Still Have Kids? What Every Man Needs to Know

    TRT can change your hormones — but it may also shut down your sperm. In this video, Dr. Justin Houman (MD, board-certified urologist & men’s health specialist) explains how testosterone replacement therapy affects fertility, sperm count, and testicular function, how long recovery can take, and...
  18. madman

    Free T vs Total T - Cutoffs and Symptoms - Where Are the Data?

    25th Annual Fall Scientific Meeting of SMSNA! Grapevine, Texas. 1:14:05-1:29:40 Recommendatios for Dealing with Free T Concept of Total Hormonal Load Keep in mind all those men with normal TT and high SHBG! Reasonable, Evidence-based Recommendation for Managing T
  19. madman

    Clomiphene or enclomiphene citrate for the treatment of male hypogonadism: a systematic review and meta-analysis of RCTs

    https://www.aem-sbem.com/article/clomiphene-or-enclomiphene-citrate-for-the-treatment-of-male-hypogonadism-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials/ ABSTRACT Objective This study aimed to evaluate the efficacy and safety of selective estrogen receptor modulators...
  20. madman

    Menopause, Myths, and the Fight for Women’s Dignity

    What if aging wasn't about being discarded, but about reclaiming your dignity and power? In this powerful episode of Innovate and Elevate, host Sharon Kedar sits down with her personal doctor, Dr. Rachel Rubin, a board-certified urologist and sexual medicine specialist. Dubbed "The Women's...
  21. madman

    The role of testosterone in cardiovascular health: benefits and risks of replacement therapy

    * This paper examines testosterone’s dual role in the cardiovascular system. Low levels are linked to increased risks of heart failure (HF) and coronary artery disease (CAD), while testosterone replacement therapy (TRT) can improve heart function, exercise tolerance, and metabolic health...
  22. madman

    Thriving Sex Life Beyond Menopause: Expert Secrets on Pleasure and Longevity

    * She has made it her mission to debunk myths about female pleasure, break down the science of sexual function, and empower women to reclaim their bodies, desire, and confidence at any stage of life. Here’s a topic that’s often overlooked, dismissed, or shrouded in stigma: sexual longevity...
  23. madman

    You Are Not Broken: Why Women Need Testosterone

    * Why testosterone is a game-changer for women in perimenopause and menopause Do you feel dismissed, broken, or completely alone during perimenopause or menopause? You’re not broken—and it’s time we change the narrative. In this powerful episode, I’m joined by Dr. Kelly...
  24. madman

    SynergenX Makes History: For the First Time, Women Nationwide Gain Access to Custom-Dosed Testosterone Injections Previously Reserved for Men

    * This expansion marks the first time that female patients can access the custom-dosed testosterone cypionate injections available to male patients, enabling them to experience the benefits of injection-based testosterone therapy. * Female patients will be able to choose from in-office...
  25. madman

    Updates in male hypogonadism: what is functional hypogonadism and how should it be managed?

    Dr Channa Jayasena Functional hypogonadism - what is it? SUMMARY: Men with functional. hypogonadism Conclusion - before considering TRT Conclusions if initiating TRT
  26. madman

    Viral TikTok Trend ‘Testosterone Maxxing’ Sparks Alarm: Experts Warn of Serious Health Risks for Teens

    SHALIN SHAH https://news3lv.com/news/videos/dangerous-tiktok-trend-testosterone-maxxing-raises-health-concerns LAS VEGAS (KSNV) — A new TikTok trend known as "Testosterone Maxxing" is raising alarms among health experts. The trend, which encourages adolescent boys to take testosterone to...
  27. D

    Anyone got a solid recipe for making scrotal testosterone cream (using testosterone base)?

    Hey, does anyone have a simple recipe for making scrotal testosterone cream? I’ve got testosterone base on hand and want to turn it into a cream, ideally something not too crazy, with easy-to-get ingredients and not too many steps. Maybe someone here has already done that and can recommend...
  28. madman

    Game-Changing Prostate Cancer Breakthroughs: Robotic Surgery, Testosterone Therapy & AI Shaping Men’s Health

    * The conversation also tackles testosterone therapy in men with prostate cancer, a complex and sometimes controversial issue. Gonzalgo emphasizes individualized decisions, noting that for men with lower- to intermediate-risk disease, continuing therapy may be reasonable. Both physicians stress...
  29. 1

    Is Omega 3 an AR killer??

    Does DHA inhibit androgen receptors or mRNA??
  30. madman

    How Testosterone Levels Impact Men's Immunity: New Research Uncovers Sex Differences in Infection and Cancer Risk

    Sex differences play a crucial role in shaping human immune responses, influencing susceptibility to infections, cancer, and autoimmune diseases. Overview of Sex-Based Immune Differences Females generally exhibit more robust immune responses than males, resulting in fewer severe infections and...
  31. madman

    Sexual Health as a Vital Sign: What Erectile and Sexual Dysfunction Reveal About Overall Health

    Erectile and sexual dysfunction aren’t just about intimacy—they can be powerful indicators of your overall health. In this eye-opening discussion, renowned urologist Dr. Mohit Khera joins Dr. Jeffrey Albaugh, a board-certified Advanced Practice Urology Clinical Nurse Specialist who specializes...
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