Anastrozole worriment urgent.

[AMR2251]

Starting in December 2025 I began a 160mg TRT weekly protocol that has HCG 250mg monday wednesday friday however the clinic had closed for approximately two weeks. I ended up taking a test booster called EVL Test that has the following

Vitamin D3- 50 Mcg

Vitamin B6- 11mg

Magnesium 160 mg

Zinc 30mg

Daspartic acid- 3120mg

Tribulus terrestris extract - 750 mg

Fenugreek extract- 500mg

DIM- 250mg

historically I have been a high aromatizer so 8 hours later on June 8th 2026 I took .25 Anastrazole. within hours I developed immediate 100% sexual dysfunction this continues to date. In addition to waking up every four hours when asleep. Nocturnal tumescence occured minimally the morning of 6/19.

I ordered a sensitive assay panel that will be back in approx 15 days ( Lab corp) Non sensitive labs show a 30 but im aware this may be a ghost value that is 7 points less than what my usual optimal level is anyway.

On 6/11 I resumed my usual 160mg TRT weekly protocol and 250 HCG monday wednesday friday protocol.

Its now been 10 days since the incident. I have scheduled an endo appointment 7/28/2026 in the event of no improvement.

Google AI indicates that this is merely an estrogen crash but I wanted to know what kind of timeline am I looking at before I deem this permanent damage

Could it be a mere estrogen crash or perhaps something bigger? Your thoughts?

 

[FunkOdyssey]

Could it be a mere estrogen crash or perhaps something bigger? Your thoughts?

If this experience has put the fear of aromatase inhibition in your heart, it will truly have been a blessing for your long-term health and well-being. You'll want to shed this self-conception you have as a high aromatizer, and adopt a newer and truer perspective: you've simply been overdosing on this combination of TRT and hCG, if it produced estrogenic symptoms that were temporarily relieved by anastrozole.

Find a dose of each that doesn't produce estrogenic symptoms (including going all the way down to zero on hCG if needed). Throw the anastrozole in the garbage. Let the time pass, and you will likely heal.

You are no special high aromatizing flower - your current protocol would probably bring at least half of men to their knees with side effects. It was never a safe assumption that you would be able to get away with it.

 

[Seagal]

Maybe it's not the anastrozole but the tribulus, fenugreek and DIM.

 

[AMR2251]

If this experience has put the fear of aromatase inhibition in your heart, it will truly have been a blessing for your long-term health and well-being. You'll want to shed this self-conception you have as a high aromatizer, and adopt a newer and truer perspective: you've simply been overdosing on this combination of TRT and hCG, if it produced estrogenic symptoms that were temporarily relieved by anastrozole.

Find a dose of each that doesn't produce estrogenic symptoms (including going all the way down to zero on hCG if needed). Throw the anastrozole in the garbage. Let the time pass, and you will likely heal.

You are no special high aromatizing flower - your current protocol would probably bring at least half of men to their knees with side effects. It was never a safe assumption that you would be able to get away with it.

Sensitive E2 came back with 27 e2 much less than my usual past results of 38-40 cortisol came up slightly elevated at 21

Would the complete dysfunction be blamed on the estrogen crash entirely or could this be some form of brain issue due to cross interaction with EVL test?

 

[FunkOdyssey]

Would the complete dysfunction be blamed on the estrogen crash entirely or could this be some form of brain issue due to cross interaction with EVL test?

Probably just the estrogen crash. There's certainly a bunch of garbage that you don't want in that EVL product, but because anastrozole alone is known to cause the effects you're experiencing, I don't think you need to look further.

Three steps to a better future:

1) dispose of anastrozole
2) dispose of EVL test
3) secure a personally controlled supply of testosterone that you administer yourself, at a dose that does not produce bothersome side effects

 

[AMR2251]

Probably just the estrogen crash. There's certainly a bunch of garbage that you don't want in that EVL product, but because anastrozole alone is known to cause the effects you're experiencing, I don't think you need to look further.

Three steps to a better future:

1) dispose of anastrozole
2) dispose of EVL test
3) secure a personally controlled supply of testosterone that you administer yourself, at a dose that does not produce bothersome side effects

Thanks typically what does recovery time look like on something like this ?

 

[FunkOdyssey]

Thanks typically what does recovery time look like on something like this ?

Varies widely, in some cases a week or two, in some cases much longer. All you can do is wait it out. Get yourself some ED medication so you can function sexually at some level in the meantime.

 

[AMR2251]

Varies widely, in some cases a week or two, in some cases much longer. All you can do is wait it out. Get yourself some ED medication so you can function sexually at some level in the meantime.

Varies widely, in some cases a week or two, in some cases much longer. All you can do is wait it out. Get yourself some ED medication so you can function sexually at some level in the meantime.

Varies widely, in some cases a week or two, in some cases much longer. All you can do is wait it out. Get yourself some ED medication so you can function sexually at some level in the meantime.

As far as the sleep thing goes since I keep waking at 4 am which has to be the cortisol spike will that interrupt recovery progress in this? Will the waking stop once e2 levels go up ?

 

[FunkOdyssey]

As far as the sleep thing goes since I keep waking at 4 am which has to be the cortisol spike will that interrupt recovery progress in this? Will the waking stop once e2 levels go up ?

Don't assume that waking up at 4 am relates to a cortisol spike. Once you start confidently attributing symptoms to this or that mechanism, the tendency is to try to intervene, which is usually a mistake and leads to a death spiral of making everything worse. That's how you got into this predicament in the first place.

The very best thing you can do, besides the three steps I gave you above, is get off the Internet and stop worrying about it. Time will heal you. Go do something else in the meantime.

 

[AMR2251]

Don't assume that waking up at 4 am relates to a cortisol spike. Once you start confidently attributing symptoms to this or that mechanism, the tendency is to try to intervene, which is usually a mistake and leads to a death spiral of making everything worse. That's how you got into this predicament in the first place.

The very best thing you can do, besides the three steps I gave you above, is get off the Internet and stop worrying about it. Time will heal you. Go do something else in the meantime.

You’re right and good advice. I was merely going by the lab value for AM cortisol it’s 21 slightly above the reference line.

 

[Leeman]

Thanks typically what does recovery time look like on something like this ?

If I go below 160 p/wk I may as well be off TRT! ***I'm DEF not saying this is etched in stone for everyone. Or for ANYONE, other than me. But, I've been on for 10+ yrs, have every Lab ever done, I log everything and micro manage like probably few people on here or anywhere do. I won't claim to know it all. Cause I don't AND things (physically) for me continue to change and evolve...

I am also very sensitive to E2. Whether too High OR too Low. I can list the High or Low E2 sypMtoms that typically accompany my TRT. My sweet spot used to be ABSOLUTE! 20-30 Any higher or lower produced adverse sides. I was so sensitive I did not even need a damn Lab to almost conclude High/Low with absolute certainty and accuracy.

SYMPTOMS:

First and foremost; When one is Low (E2) they can typically get it up and the erection quality can be good. Maybe even super Hard. BUT! Def NOT alive feeling. Low sensitivity and Loss of Libido. Tired, oversleeping and sleeping too often or too well! Fatigued feeling. More frequent urination. Getting up multiple times a night peeing. Difficulty retaining water, may have some constipation or stiffer stools...

High E2; Softer erections, trouble reaching orgasm if at all. Low libido. Anxiety, obsessive thoughts, trouble sleeping at night, quick to anger, feeling abnormally hot, night sweats, Nipple sensitivity, Brain fog, craving more chocolate/sugary carbs, water retention, bloated feeling, rings fit tighter, less frequent urination -thin stream, feeling more emotional -sentimental...

Those are some of the main signs. But, sometimes things over lap. So, I look at my current trend and determine how many Low Vs High symptoms I have. Typically, if I have 2-3 in one category, (or at least 2-3 More in one category) that determines it for me. (plus, after enough experience monitoring yourself you just know.)

With your present condition, there could be several reasons or possibilities for your issues. Unfortunately, you have had several abnormal events (inconsistencies) in your routine to be able to pin point the specific cause...

There are things you can do to help offset (correct) an E2 imbalance. But, time and 100% consistency will be your best (most dependable) ally.

Either High or Low, it's Not a Big deal or health risk. It is a Big inconvenience and will test your patience for sure!

I'd be curious which category (High or Low) you feel you fall into, based on my "SYMPTOMS" list?

You "may" need to lower your TRT dosage. I will not get in the middle of that. Without your complete health and TRT history, dosage, exercise regimen, etc... any advice would just be pure speculation on my part

 

[AMR2251]

If I go below 160 p/wk I may as well be off TRT! ***I'm DEF not saying this is etched in stone for everyone. Or for ANYONE, other than me. But, I've been on for 10+ yrs, have every Lab ever done, I log everything and micro manage like probably few people on here or anywhere do. I won't claim to know it all. Cause I don't AND things (physically) for me continue to change and evolve...

I am also very sensitive to E2. Whether too High OR too Low. I can list the High or Low E2 sypMtoms that typically accompany my TRT. My sweet spot used to be ABSOLUTE! 20-30 Any higher or lower produced adverse sides. I was so sensitive I did not even need a damn Lab to almost conclude High/Low with absolute certainty and accuracy.

SYMPTOMS:

First and foremost; When one is Low (E2) they can typically get it up and the erection quality can be good. Maybe even super Hard. BUT! Def NOT alive feeling. Low sensitivity and Loss of Libido. Tired, oversleeping and sleeping too often or too well! Fatigued feeling. More frequent urination. Getting up multiple times a night peeing. Difficulty retaining water, may have some constipation or stiffer stools...

High E2; Softer erections, trouble reaching orgasm if at all. Low libido. Anxiety, obsessive thoughts, trouble sleeping at night, quick to anger, feeling abnormally hot, night sweats, Nipple sensitivity, Brain fog, craving more chocolate/sugary carbs, water retention, bloated feeling, rings fit tighter, less frequent urination -thin stream, feeling more emotional -sentimental...

Those are some of the main signs. But, sometimes things over lap. So, I look at my current trend and determine how many Low Vs High symptoms I have. Typically, if I have 2-3 in one category, (or at least 2-3 More in one category) that determines it for me. (plus, after enough experience monitoring yourself you just know.)

With your present condition, there could be several reasons or possibilities for your issues. Unfortunately, you have had several abnormal events (inconsistencies) in your routine to be able to pin point the specific cause...

There are things you can do to help offset (correct) an E2 imbalance. But, time and 100% consistency will be your best (most dependable) ally.

Either High or Low, it's Not a Big deal or health risk. It is a Big inconvenience and will test your patience for sure!

I'd be curious which category (High or Low) you feel you fall into, based on my "SYMPTOMS" list?

You "may" need to lower your TRT dosage. I will not get in the middle of that. Without your complete health and TRT history, dosage, exercise regimen, etc... any advice would just be pure speculation on my l

My TRT clinic was closed approx two weeks so I wasn’t getting any injections.

On 6/9 I took a supplement called EVL test before bed that had the ingredients above. Woke up and took .25 anastrozole I took this because the supplement had d aspartic acid and had concerns about high e2

I lost all sexual function the day I took the anastrozole. Even with cialis just no response. Other than that I been waking up at 4 am. I would say low

It’s been approx 11 days so all of this should be out of my system.

I did resume my usual weekly 160mg on 6/11 and had 250 Monday Wednesday Friday

Recent sensitive labs indicated an e2 of 27 cortisol at 21 testosterone is 435

I am hoping this is just a situation where I crashed under my personal threshold this doesn’t seem to have the characteristics of the people who crashed to zero as I can still function coherently lots of people report night sweats. Although I did experience the tight pelvic floor and frequent urination so I want to say this is crashed via tissues

 

[Leeman]

My TRT clinic was closed approx two weeks so I wasn’t getting any injections.

On 6/9 I took a supplement called EVL test before bed that had the ingredients above. Woke up and took .25 anastrozole I took this because the supplement had d aspartic acid and had concerns about high e2

I lost all sexual function the day I took the anastrozole. Even with cialis just no response. Other than that I been waking up at 4 am. I would say low

It’s been approx 11 days so all of this should be out of my system.

Recent sensitive labs indicated an e2 of 27 cortisol at 21 testosterone is 435

I am hoping this is just a situation where I crashed under my personal threshold this doesn’t seem to have the characteristics of the people who crashed to zero as I can still function coherently lots of people report night sweats. Although I did experience the tight pelvic floor and frequent urination so I want to say this is crashed via tissues

For me personally, when I would awaken at an unusual time (i.e. 3am) for a few days, it would typically be accompanied by Slight anxiety, (anxious thought patterns) and also night sweats or at least abnormally Hot feeling. (Of course, these same symptoms "Can" come from other influences... Like the house too hot, or being under excess stress) But, these symptoms would often times be associated with High E2 for me.

Cortisol can spike in the night typically between 2-4am especially if your body needs FOOD! This may or may not be your issue. But, it "could be" a piece of the waking puzzle. I've suffered from that before. Once waking up, like that starts screwing with your mind, the cortisol increases and compounds the thing you are already stressing over. -GETTING BACK TO SLEEP!! So, I've learned to just tell my body; "alright let's get up and eat some toast and have a protein drink. F it, if we stay up, we stay up! I don't care either way"!!! It's a hard sale to convince yourself that you don't really care. But, it's the only way I have found to take the pressure off NEEDING TO SLEEP! stressing and simply dumping even more cortisol into the mix!!

I have crashed my E2 and it is not fun! But, it does come back and it wasn't that traumatic. There are things one can do to help encourage a rise in E2. But, the simplest way is to do one bolus IM injection instead of 3 for a couple weeks. THC can encourage a rise in E2.

Tell tale signs like peeing more or less and tighter rings are pretty EZ to identify and help point you in the right direction. But, even that can be skewed by alcohol and/or excessively salty foods the day before the bad sleep or noticing the rings fit tight. Even a common cold coming on can make you pee more often and not drinking enough water can make you dehydrated and pee less! So, there's an art to this kind of monitoring and as much day to day consistency as possible is vital.

Again, it's not a Big deal. This too shall pass.

 

[Seagal]

Sensitive E2 came back with 27 e2 much less than my usual past results of 38-40 cortisol came up slightly elevated at 21

Would the complete dysfunction be blamed on the estrogen crash entirely or could this be some form of brain issue due to cross interaction with EVL test?

What about freeT, as usual after a two week break?

 

[AMR2251]

What about freeT, as usual after a two week break?

Didnt get this ran yet --- I guess im trying to figure out if this is just a ratio problem due to the anastrazole im continuing on the same regimen until I can consult with the endo 7/28.

Symptoms are no libido, No sensitivity or ability to gain erection, Slightly high cortisol and inability to sleep past a certain hour. Today was 2 AM. Day- 12

 

[Seagal]

Didnt get this ran yet --- I guess im trying to figure out if this is just a ratio problem due to the anastrazole im continuing on the same regimen until I can consult with the endo 7/28.

Symptoms are no libido, No sensitivity or ability to gain erection, Slightly high cortisol and inability to sleep past a certain hour. Today was 2 AM. Day- 12

Imho it seems like you panicked when you ran out of testo. Did you use anastrozole before that? Now you are so focused on E2 and seem to forget the drop in your T level you experienced. The hormone roller coaster might have caused all your symptoms. It will return back to normal!

 

[AMR2251]

Imho it seems like you panicked when you ran out of testo. Did you use anastrozole before that? Now you are so focused on E2 and seem to forget the drop in your T level you experienced. The hormone roller coaster might have caused all your symptoms. It will return back to normal!

I was using anastrazole yeah prior when I was on the shots.

 

[Seagal]

I was using anastrazole yeah prior when I was on the shots.

Just continue with your prior protocol for now.
In your situation I would have taken the missed T dose on top of the regular dose to get quicker back to my normal levels.

 

[AMR2251]

Just continue with your prior protocol for now.
In your situation I would have taken the missed T dose on top of the regular dose to get quicker back to my normal levels.

Yes I will continue. It’s just a bit scary that the tiny bit of Anastrazole was 100% the trigger for this

 

[Phil Goodman]

Lots of great advice in this thread, so the only thing I’d ask is - Do you have to go into the clinic for your injections? If not, I don’t see why you’d freak out about it closing for two weeks. And if so, you should consider getting a different provider. Imagine any other doctors requiring their patients to go into the office to get their medication. Now imagine that same office closing for two weeks. Both of those are bad signs, and that’s before even getting into the issue of them putting you on an AI.