US Ketamine Clinic Directory 2026: IV, Spravato, At-Home and KAP Providers by State

ExcelMale’s US ketamine clinic directory lists 99 providers across all 50 states and DC, showing which offer IV, IM, Spravato, nasal or at-home ketamine and which include ketamine-assisted psychotherapy (KAP).

This directory lists 99 ketamine providers across all 50 states and DC: national networks, telehealth programs, academic centers and independent clinics. For each one you'll find the routes of ketamine they offer and whether counseling or therapy is part of treatment.

Background about ketamine and depression


US Ketamine Clinic Near Me.webp



The tables follow in the replies below, grouped by region.

Ketamine routes​

  • IV infusion: intravenous drip in a clinic. The most studied route, usually cash-pay.
  • IM injection: intramuscular shot in a clinic. Shorter session than IV.
  • Spravato: FDA-approved esketamine nasal spray. Given only in REMS-certified clinics with 2-hour observation. Often covered by insurance.
  • Compounded nasal spray: racemic ketamine spray from a compounding pharmacy. Off-label.
  • Sublingual / oral: troches, lozenges or rapid-dissolve tablets, in clinic or at home.
  • At-home: telehealth-prescribed ketamine taken at home with remote oversight.

Therapy categories​

  • KAP in-house (32): a licensed therapist delivers ketamine-assisted psychotherapy.
  • Integration in-house (15): preparation and integration sessions, coaching or talk therapy in-house, but not full KAP.
  • Referral / separate (16): the clinic works with your own therapist or refers out.
  • Not stated (36): the clinic's site doesn't describe a therapy component. That doesn't prove they lack one.

This list is for information only. It is not an endorsement or medical advice. Talk to your doctor before starting ketamine, especially if you take other psychiatric medications or have high blood pressure, heart disease or a history of psychosis or substance use.

Know a clinic that should be added, or spot an error? Reply below.
 
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National networks and telehealth (14)​

ClinicLocationKetamine routesCounseling / therapyConditions
MindbloomTelehealth (multi-state) (National)At-home sublingual tablets, at-home subcutaneous injectionIntegration in-house: 1:1 guide coaching for prep/integration, unlimited group integration circles; coaching, not licensed psychotherapy; peer monitor required at sessionsDepression, anxiety, PTSD
Better UTelehealth (multi-state) (National)At-home sublingual troches/RDT, compounded nasal spray (provider-directed)Integration in-house: 1:1 integration coaching plus "Neuroplastic Therapy" program; talk therapy add-ons in higher plansDepression, anxiety, PTSD, chronic pain
InnerwellTelehealth (multi-state) (National)At-home sublingual/oral RDTKAP in-house: Licensed psychotherapists can join before/during/after sessions; also psychiatry and EMDR; insurance in some statesDepression, anxiety, PTSD, OCD, trauma
JoyousTelehealth (multi-state) (National)At-home very-low-dose oral/sublingual (daily, psycholytic)Integration in-house: Telehealth check-ins and Be.Joyous online platform; no formal psychotherapy includedDepression, anxiety, PTSD, chronic stress, OCD
NushamaNew York (Midtown); New City NY; Aventura FL (NY, FL)IV infusion, IM, oral, Spravato (Aventura)KAP in-house: Core package bundles 6 preparation + 6 treatments + 6 integration sessionsDepression, PTSD, anxiety, OCD, chronic pain
Stella Mental Health20+ locations (e.g., Irvine CA, Westmont IL, Brookline MA, Utah, NYC) (Multi-state)IV infusion, Spravato, also SGB and TMSIntegration in-house: IV packages include matched integration therapy sessions (6 infusions + 6 integration); talk therapy and IOP at some sitesDepression, PTSD, anxiety, OCD
Serenity Mental Health Centers~35 locations (AZ, UT, CO, TX, FL, NV, GA, VA) (Multi-state)IV infusion, Spravato, IM at some sitesReferral / separate: Psychiatry, medication management and structured therapy offered as separate services; no KAP listedDepression, anxiety, OCD, PTSD
RevitalistKnoxville and Johnson City (TN)IV infusion, Spravato, KAPKAP in-house: KAP listed on site; also TMSDepression, PTSD, anxiety, chronic pain
Ember HealthNew York City (Brooklyn Heights, Chelsea, Tribeca, UES, Williamsburg) (NY)IV infusionReferral / separate: Works with patient's existing providers; no in-house KAP statedDepression, anxiety, PTSD
Keta Medical CenterManhattan (Midtown, UWS, Hudson Yards); Brooklyn; New Rochelle; Oradell NJ (NY, NJ)IV infusion, SpravatoNot stated: Site focuses on medical treatment; third-party listings say psychotherapy can be added alongside ketamineDepression, PTSD, anxiety
KlarisanaDenver, Longmont, Thornton, Centennial CO; Austin and San Antonio TX (CO, TX)IM injection, SpravatoKAP in-house: KAP, talk therapy and behavioral health team; stopped offering IV in 2020Depression, PTSD, anxiety, chronic pain, OCD
Ketamine Health CentersAltamonte Springs/Orlando; Miami; West Palm Beach (FL)IV infusion, SpravatoKAP in-house: KAP and EMDR listed; also SGB and integrative psychiatryDepression, anxiety, PTSD, chronic pain
NeuroSpa Therapy CentersTampa; Wesley Chapel; Pinellas Park; Brandon; Lakeland (FL)IV infusion, Spravato, also TMSIntegration in-house: In-house talk therapy (CBT) and medication management; not described as KAPDepression incl. suicidal ideation, anxiety, PTSD, OCD, insomnia
Principium PsychiatryNew York (Midtown, Downtown); Greenwich CT; Santa Monica CA (NY, CT, CA)IV infusion, Spravato, KAP, also TMSKAP in-house: KAP listed alongside IV and SpravatoDepression, anxiety, PTSD, OCD
 

Northeast and Mid-Atlantic (21)​

ClinicLocationKetamine routesCounseling / therapyConditions
Columbia Treatment-Resistant Depression ProgramNew York (Midtown) (NY)IV infusion, SpravatoNot stated: Academic program; also offers TMS; no ketamine-specific therapy statedTreatment-resistant depression, depression with suicidal thoughts
Creative Healing PsychiatryNew York (Upper East Side) (NY)IV infusion, IM injection, oral (for KAP)KAP in-house: Psychiatrist Dr. David Lifschutz runs KAP sessions himself, followed by an integration hourDepression/TRD, bipolar depression, anxiety, PTSD, OCD, suicidality
Ketalink Ketamine CenterLevittown (Long Island); Staten Island (NY)IV infusion, SpravatoKAP in-house: KAP by in-house KAP-trained LCSW; patients may also use their own therapistDepression/TRD, anxiety, PTSD, OCD, alcohol use disorder
KetaReviveWyckoff (NJ)IV infusion, Spravato, at-home oral and/or compounded nasal spray (monthly Rx)Not stated: Free pre-treatment consultation only; no psychotherapy or integration listedDepression/TRD, anxiety, PTSD, OCD, bipolar, chronic pain, migraine
Ketamine of PhiladelphiaPhiladelphia (PA)IV infusionNot stated: IV-only practice; series of 6 infusionsDepression/TRD, postpartum depression, PTSD, bipolar, OCD, anxiety
Mindstream MedicinePhiladelphia (PA)IV infusion, IM injectionReferral / separate: Works with patient's own therapist; connects patients without one to a provider networkDepression, anxiety
UPMC Center for Interventional PsychiatryPittsburgh (PA)IV infusion, SpravatoNot stated: Academic center; also ECT, TMS, deep brain stimulationTreatment-resistant depression
Voyage HealingBala Cynwyd (Philadelphia) (PA)IV infusion, IM injection, Spravato, nasal spray, oralKAP in-house: In-house KAP plus EMDR, ACT, breathwork, music therapy; also TMSDepression/TRD, anxiety, bipolar, PTSD, OCD, substance use, suicidal ideation
Boston MindCareLexington (Boston) (MA)IV infusion, IM injection, compounded nasal spray, oralNot stated: No therapy service listedDepression, anxiety, PTSD, OCD, bipolar, chronic pain, CRPS, migraine
Cambridge BiotherapiesCambridge; Boston; Beverly; Springfield; Amherst (MA)IV infusion, SpravatoKAP in-house: KAP with in-house therapists and integration sessions; veterans program; also TMSDepression/TRD, anxiety, PTSD, suicidal ideation
Mass General Brigham Ketamine Service (MGH / McLean)Boston; Belmont (MA)IV infusion, SpravatoNot stated: Academic service; no ketamine-specific therapy statedMDD/TRD, bipolar depression
Ketamine Center of Greater HartfordAvon (CT)IV infusionNot stated: Anesthesiologist-administered infusions; no therapy listedDepression, bipolar, anxiety, OCD, PTSD, chronic pain, CRPS, migraine
Yale New Haven Psychiatric Hospital – Esketamine & Ketamine ServiceNew Haven (CT)IV infusion, SpravatoNot stated: Academic hospital program; no psychotherapy pairing statedTRD, MDD with suicidal thoughts
PVD Ketamine & WellnessProvidence (RI)Spravato, sublingual, IM injection, at-home sessions with Zoom supportKAP in-house: Each session has 30-60 min prep, 60-min medicine session, 30-60 min integrationDepression, anxiety, PTSD, OCD, bipolar, substance use
New England KetamineSalem (NH)IV infusionNot stated: CRNA/PMHNP-run; requires documented diagnosis or referralTRD, anxiety, PTSD, chronic pain
Taconic PsychiatryManchester (VT)IM injection (in-office), at-home sublingual ODTIntegration in-house: In-office sessions end with MD debrief; practice employs psychologists (CBT, ERP); KAP not namedDepression, anxiety, bipolar, PTSD, OCD, substance use
Integr8 HealthFalmouth (ME)Compounded oral troches/ODT, compounded nasal spray, IM injectionNot stated: Integrative practice focused on low-dose oral ketamineDepression, anxiety, chronic pain, headache
Baltimore Ketamine ClinicSparks (Baltimore) (MD)IV infusion, IM injection, SpravatoReferral / separate: Recommends seeing your own therapist 24-48 h after each sessionDepression, anxiety, bipolar, PTSD, OCD, addiction, suicidal ideation
DC Ketamine ClinicWashington (downtown) (DC)IV infusionNot stated: Anesthesia-led; also lidocaine infusionsTRD, bipolar and postpartum depression, PTSD, anxiety, chronic pain
Washington Interventional PsychiatryWashington DC (Spring Valley); Rockville MD (DC, MD)IV infusion, IM injection, Spravato, troches (with KAP)KAP in-house: KAP with licensed therapist; also TMS, SGBDepression/TRD, anxiety, PTSD, substance use
Therapeutic InfusionsWilmington (DE)IV infusion, SpravatoIntegration in-house: KAP done with patient's referring therapist; in-house integration coaching and talk therapy by psychiatric NPsTRD, PTSD, anxiety


Southeast (21)​

ClinicLocationKetamine routesCounseling / therapyConditions
Ketamine & Wellness Clinic of South FloridaPompano Beach; Hallandale (FL)IV infusion, SpravatoIntegration in-house: Integration coach on staffDepression, anxiety, PTSD, chronic pain
NeuroPain Health (Dr. Michelle Weiner)South Miami; Hollywood; Deerfield Beach (FL)IV infusion, IM injectionKAP in-house: KAP, integration coaching, group integration Zoom calls; does not prescribe esketamineDepression, suicidal thinking, PTSD, anxiety, OCD, fibromyalgia, CRPS
Orlando Premier PsychiatryOrlando (FL)IV infusionIntegration in-house: In-house psychotherapy, trauma and family therapy; KAP not described specificallyDepression/TRD, anxiety, PTSD, mood disorders
Rewired KetamineAventura (Miami) (FL)IV infusion, Spravato, at-home optionIntegration in-house: Integration team works with patient after each session; talk therapy offered; guided sessions availableTRD, anxiety, PTSD, OCD, chronic pain, postpartum depression
Sana KetamineOrlando (FL)IV infusion, IM injection (when IV not possible)Referral / separate: Stresses prep and integration but directs patients to their own therapist or coachTRD, bipolar depression, anxiety, PTSD, OCD, CRPS
TampaPainMD (Dr. Kalava)Tampa (FL)IV infusionNot stated: Concierge interventional pain practiceTRD, PTSD, bipolar depression, OCD, fibromyalgia, CRPS
Atlanta Center for Ketamine TherapySmyrna (Atlanta) (GA)IV infusion, SpravatoNot stated: No counseling describedDepression, anxiety, PTSD, chronic pain
Dr. Sambunaris & AssociatesAlpharetta (Atlanta) (GA)IM injectionNot stated: Psychiatry practice; no counseling component described for ketamineDepression, anxiety, PTSD, chronic pain, substance dependence
Georgia Psychiatric ConsultantsAtlanta (GA)Spravato, IV infusion, compounded nasal spray (in-clinic)Referral / separate: Medical management; works closely with patient's psychotherapistMDD, TRD, PTSD, bipolar depression, anxiety, chronic pain
Charlotte Ketamine CenterCharlotte (NC)IV infusion, IM injection, Spravato, nebulized, home programNot stated: No counseling describedDepression, anxiety, PTSD, migraine, neuropathic pain
Dérive HealthCharlotte; Pinehurst (NC)IV infusionNot stated: Markets "psychedelic-assisted therapy" but no therapist service described; emergency-medicine cliniciansTRD, anxiety, PTSD, OCD, bipolar, substance use, migraine, CRPS
Charleston Ketamine CenterMt. Pleasant; Columbia (SC)IV infusion, SpravatoNot stated: No counseling describedTRD, anxiety, PTSD, OCD, chronic pain, migraine
MindPeace ClinicsRichmond/Henrico; Charlottesville (VA)IV infusion, SpravatoNot stated: No therapist-guided sessions; does not accept insuranceTRD, suicidal ideation, anxiety, PTSD, OCD, migraine, chronic pain
Harmony (Transformations Care Network)Morgantown; Bridgeport; Charleston; Martinsburg; Wheeling (WV)SpravatoIntegration in-house: Outpatient therapy and psychiatry in-house; not ketamine-specific KAPDifficult-to-treat depression
Music City KetamineFranklin (Nashville) (TN)IV infusionNot stated: CRNA-administered infusionsTRD, PTSD, grief, chronic pain
Tennessee Ketamine & Wellness CenterFranklin (Nashville) (TN)IV infusion, SpravatoReferral / separate: Collaborates with patient's existing care teamDepression, PTSD, anxiety, OCD, opioid and alcohol dependence, chronic pain
Ketamine of LouisvilleLouisville (KY)IV infusionNot stated: No counseling describedDepression, anxiety, bipolar depression, trauma
Southern Ketamine & WellnessVestavia Hills (Birmingham); Opelika (AL)IV infusion, SpravatoReferral / separate: Works with patients' psychotherapists; free IV ketamine for VA-referred veteransDepression, anxiety, PTSD, OCD, substance use, fibromyalgia, CRPS, migraine
Gulf Coast NeuroSpaGulfport; Ocean Springs MS; Pensacola FL (MS)SpravatoNot stated: Psychiatry and TMS practiceTreatment-resistant depression
Kismet Ketamine ClinicBaton Rouge (LA)IV infusionNot stated: No counseling describedDepression, anxiety, PTSD, CRPS, fibromyalgia, migraine
UAMS Psychiatric Research Institute – Interventional PsychiatryLittle Rock (AR)IV infusion, SpravatoNot stated: Academic program; interdisciplinary team; no KAP describedTRD/MDD with suicidal thoughts, bipolar, PTSD, chronic pain



Midwest and South-Central (22)​

ClinicLocationKetamine routesCounseling / therapyConditions
Austin Ketamine ClinicAustin (TX)IV infusion, IM injectionReferral / separate: Partners with outside providers and therapistsTRD, anxiety, PTSD, OCD, substance use, suicidality
Lone Star InfusionHouston (TX)IV infusion (low- and high-dose protocols)KAP in-house: Optional KAP during IV infusion with a therapist who also runs integration; also nitrous oxideDepression, anxiety, PTSD, bipolar, CRPS, chronic pain
Texas Ketamine SpecialistsDallas (TX)IV infusion, sublingual lozenge (in-clinic KAP)KAP in-house: Intake plus 6 KAP sessions: lozenge then 45-min session with psychotherapistDepression, bipolar, anxiety, postpartum, PTSD, migraine, fibromyalgia, addiction
Transcend Health SolutionsSan Antonio; Austin (TX)IV infusion (KAP)KAP in-house: Every IV session guided by a licensed KAP therapist with prep and integration; veteran/first-responder owned; sliding scaleTrauma, depression, anxiety, PTSD, OCD, postpartum depression, chronic pain
UT Southwestern Interventional PsychiatryDallas (TX)Spravato, ketamine (route not stated)Referral / separate: Academic program; refers to psychotherapy or coordinates with primary providerSevere/treatment-resistant depression, OCD
UTHealth Houston Center for Interventional PsychiatryHouston (TX)IV infusion, SpravatoIntegration in-house: Academic center; treatment integrated with in-house individual and group psychotherapy; no KAP describedTRD, TR bipolar, TR OCD, catatonia, severe suicidality
Oklahoma Pain Treatment CentersOklahoma City; Edmond; Norman; Yukon; Midwest City (OK)IV infusionNot stated: Pain-focused; no ketamine-linked therapyChronic pain
Innovative MindCareChicago (Lakeview); Downers Grove (IL)IV infusion, SpravatoKAP in-house: KAP sessions with affiliated Innovative Therapy practice, or referral outDepression, anxiety, PTSD, complex mood disorders
Northwestern Medicine Psychiatric ClinicChicago (IL)IV infusionReferral / separate: Academic; requires an established outside mental health provider; integration therapy recommendedTreatment-resistant major and bipolar depression, suicidal thoughts
MiNDSET Integrative Ketamine CareColumbus (OH)IV infusionIntegration in-house: On-site psychologist offers intention-setting and integration psychotherapy ($195/hr)Depression, anxiety, suicidal ideation, chronic pain
New Pathways ClinicColumbus; Cleveland; Cincinnati; Toledo (OH)IV infusion, SpravatoKAP in-house: On-site KAP counselor in Middleburg Heights; partner offers virtual KAP statewideTRD, PTSD, anxiety, bipolar, OCD, suicidal ideation
Michigan Progressive HealthRoyal Oak; Ann Arbor (MI)IV infusion, IM injection, oral (KAP), SpravatoKAP in-house: Therapist present in every KAP medicine session; group KAP offeredDepression, chronic pain, anxiety, bipolar, PTSD, migraine, fibromyalgia
Red Maple WellnessNoblesville; Indianapolis (IN)Sublingual lozenge (in office)KAP in-house: Licensed psychotherapist runs intake, dosing sessions and integration; EMDR, IFS, somaticDepression/TRD, anxiety, PTSD, OCD, grief
Forward Ketamine of WisconsinMadison (WI)IV infusionNot stated: Infusion services onlyDepression, anxiety, PTSD, chronic pain, OCD, migraine
Catalyst Insight CollectiveSt. Anthony (Minneapolis) (MN)IM injection, subcutaneous injection, SpravatoKAP in-house: In-house KAP with prep and integration; psychotherapy and psychedelic integrationDepression/TRD, anxiety, PTSD, grief, postpartum
The Remedy Mental HealthGolden Valley; Maple Grove; Burnsville; Vadnais Heights (MN)IV infusion, SpravatoIntegration in-house: In-house therapy offered separately; site says it does not provide KAPTRD, anxiety, ADHD, OCD, PTSD
WashU Medicine Interventional PsychiatrySt. Louis (MO)SpravatoNot stated: Academic; esketamine alongside ECT, TMS, VNSTreatment-resistant depression
Corridor KetamineCoralville; North Liberty; Davenport (IA)IV infusion, SpravatoReferral / separate: Works in tandem with patient's existing mental health careTreatment-resistant depression
University of Kansas Health System – PsychiatryKansas City (KS)IV infusion, SpravatoNot stated: Academic department; general psychotherapy available but not tied to ketamineTreatment-resistant depression
Elevate Mind & MoodLincoln (NE)IV infusionReferral / separate: Patients must work with a therapist before, during and after infusionsTRD, anxiety, PTSD, chronic pain
ReNewed Wellness and Ketamine ClinicFargo; Grand Forks (ND)IV infusionNot stated: CRNA-administered; no counseling listedDepression, bipolar, anxiety, OCD, PTSD, chronic pain
South Dakota Ketamine ClinicSioux Falls (SD)IV infusionReferral / separate: Partners with PAX Institute psychiatry practiceDepression, bipolar, PTSD, anxiety, chronic pain

West (21)​

ClinicLocationKetamine routesCounseling / therapyConditions
Bay Psychiatric AssociatesBerkeley; SF; San Mateo; Corte Madera (CA)IM injection, IV infusion (SF only), SpravatoKAP in-house: KAP on a limited basis with select clinicians; general therapy also offered; no take-home ketamineTreatment-resistant depression, PTSD
Golden AfternoonSanta Monica (CA)IV infusion, IM injection, SpravatoIntegration in-house: Physician or NP meets patient before and after sessions for integration; links to an outside integration therapist networkDepression, anxiety, mood disorders, PTSD, chronic pain
Kadima Neuropsychiatry InstituteLa Jolla (San Diego) (CA)IV infusion, IM injection, SpravatoKAP in-house: In-house therapists for psychedelic-assisted therapy with prep and integration; NRx/HOPE Therapeutics announced intent to acquire (2025)Depression, suicidal ideation, PTSD, OCD, addiction, eating disorders, chronic pain
Ketamine Clinics Los Angeles (KCLA)Los Angeles (CA)IV infusion, SpravatoNot stated: Site lists holistic psychiatry and a patient referral page; no in-house talk therapy describedDepression, anxiety, PTSD, OCD, addiction, mood disorders
Polaris Insight CenterSan Francisco (CA)Sublingual/oral lozenge (in-office KAP)KAP in-house: Structured KAP: intake, preparation sessions, 2-3 hour KAP sessions, integration sessionsComplex PTSD/trauma, dissociative disorders, mood disorders, chronic pain, existential distress
Seaside KetamineCardiff-by-the-Sea (San Diego) (CA)IV infusion, IM injection, SpravatoKAP in-house: KAP listedDepression, anxiety, PTSD
Portland Ketamine ClinicPortland (OR)IV infusion (anesthesiologist-administered)Not stated: Requires psychiatrist referral renewed monthly; integration page has no detailsDepression, chronic pain (CRPS), PTSD, bipolar, OCD, anxiety
Rainfall MedicinePortland (OR)IV infusion, IM injection, sublingualKAP in-house: Dedicated KAP service with LMFT therapists on staffDepression, anxiety, PTSD, addiction, chronic pain, OCD, end-of-life anxiety
AIMS InstituteSeattle (WA)IM injection, take-home compounded lozenges, pain infusionKAP in-house: 6-week program of ~120-min sessions with integration; group KAP; home KAP for hospice/palliative patientsDepression, anxiety, existential anxiety, PTSD, eating disorders, chronic pain, serious illness
Northwest Ketamine ClinicsSeattle; Bellevue; Tacoma (WA)IV infusion, Spravato (via partner)KAP in-house: KAP and integration sessions offered through partner Northwest Healing & WellnessDepression, anxiety, PTSD, OCD, postpartum and bipolar depression, chronic pain, migraine
Calm ClinicLas Vegas (NV)Spravato, IM injection, sublingual tabletsKAP in-house: Prep by KAP-trained licensed therapist plus integration psychotherapy; patient's own therapist can joinTRD, substance dependence, PTSD, OCD
Kadelyx HealthPhoenix (AZ)IV infusion, IM injection, SpravatoKAP in-house: Guided and semi-guided KAP, couples and group sessions, integration offeringsDepression, anxiety, PTSD, OCD, bipolar, addiction, chronic pain, end-of-life care
Scottsdale Ketamine ClinicScottsdale (AZ)IV infusionNot stated: IV-only clinicDepression, anxiety, PTSD, chronic pain
Injection & Infusion Clinic of ABQAlbuquerque (NM)IV infusionNot stated: No therapy component mentionedDepression, anxiety, PTSD, chronic pain
Vitalitas Denver Ketamine CenterLittleton; Westminster (CO)IV infusion, SpravatoReferral / separate: No KAP; coordinates with patient's own mental health or pain providerTRD, PTSD, anxiety, OCD, chronic pain, CRPS, migraine
University of Utah Health – Huntsman Mental Health InstituteSalt Lake City (UT)IV infusionKAP in-house: Academic center; separate KAP clinic (opened 2022) and KAP research trial; infusions self-payTreatment-resistant depression; existential distress (research)
EleMental Health (formerly Boise Ketamine Clinic)Boise (ID)IV infusion, IM injection, compounded nasal spray, SpravatoKAP in-house: One-on-one therapist-guided ketamine sessions; free weekly virtual support groupDepression, anxiety, PTSD, OCD, bipolar, addiction, chronic pain
Big Sky Ketamine CareMissoula (MT)IV infusion onlyNot stated: Infusion and psychiatric provider; no KAP describedDepression, anxiety, PTSD, OCD, bipolar, suicidal ideation
Wyoming Wellness CenterTorrington; Cheyenne (WY)IV infusion, IM injection, sublingual (per third-party listing)Not stated: Mentions "ketamine assisted therapy" but no in-house psychotherapy described; medical modelDepression, anxiety, PTSD, postpartum depression, chronic pain
Hawaii KetamineHonolulu; Kona (HI)IV infusionNot stated: No KAP or in-house therapy describedDepression, anxiety, PTSD, OCD, bipolar, substance use, chronic pain
Ketwell AlaskaAnchorage; Fairbanks; Haines (AK)IV infusion, IM (Haines)Referral / separate: KAP delivered with partner Quest Counseling & Wellness; VA-approved for veteransDepression, anxiety, PTSD, OCD, bipolar, chronic pain, migraine
 
Why ketamine for depression?

Ketamine works on a different brain system than standard antidepressants. SSRIs act on serotonin and often take 4 to 6 weeks to help. Ketamine blocks NMDA receptors in the glutamate system, and many patients feel better within hours to a day.

That speed matters most for treatment-resistant depression (TRD), meaning depression that hasn’t improved after two or more antidepressants. About one in three adults with major depression falls into this group.


  • []Fast relief from suicidal thoughts: A 2018 analysis of 167 patients found a single IV infusion reduced suicidal thoughts within one day, with benefits lasting up to a week (Wilkinson et al., American Journal of Psychiatry).
    []As effective as ECT: In the ELEKT-D trial of 403 patients with TRD, 55.4% responded to IV ketamine compared with 41.2% on electroconvulsive therapy, and ketamine patients had fewer memory problems (Anand et al., NEJM 2023).
  • FDA-approved option: Spravato (esketamine nasal spray) was approved for TRD in 2019. In January 2025 it was approved for use on its own, without a daily oral antidepressant. In that trial, 22.5% of patients were in remission at week 4, compared with 7.6% on placebo.

The limits: One dose usually wears off within a week or two, so most clinics give a series of about six treatments, then occasional boosters. Common side effects are dissociation (a temporary floaty or detached feeling), nausea and a short-term rise in blood pressure. Frequent high-dose use has been linked to bladder damage and misuse. IV, IM and oral ketamine are used off-label for depression, so insurance rarely covers them. Spravato is the main exception. Many clinics pair ketamine with therapy to help the improvement last, though research on that combination is still early.

Sources:

Wilkinson et al., Am J Psychiatry 2018
Anand et al., NEJM 2023 (ELEKT-D)
FDA approval of Spravato as a standalone treatment, January 2025 (Healio)
 

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