clomid

  1. madman

    Clomiphene Citrate in off-Label PCT: Mechanisms, Efficacy and Diagnostic Challenges in Endocrine Recovery Following AAS Use

    2 Pathophysiology of Anabolic Steroid-Induced Hypogonadism 2.1 Central and Peripheral Mechanisms of HPG Axis Suppression 2.2 Mechanisms Contributing to Delayed Recovery 3 Overview of Post-Cycle Therapy Approaches 4 Pharmacology of Clomiphene Citrate 5 Clinical Evidence of Clomiphene...
  2. madman

    Clomid for Low Testosterone: Why It May Lower HDL and Affect Cholesterol Despite Boosting Hormones

    Abstract INTRODUCTION AND OBJECTIVES: Clomiphene citrate (CC) is increasingly used off-label to treat male hypogonadism while preserving gonadal function. CC has been associated with dyslipidemia in women treated for ovulatory dysfunction, and preliminary data from our institution previously...
  3. madman

    Azoospermia on TRT? hCG vs Clomid for Fertility—Why Sperm Recovery May Not Depend on FSH

    Abstract INTRODUCTION AND OBJECTIVES: To evaluate FSH recovery rates and sperm production in men with testosterone therapy (TTh)-induced azoospermia treated with hCG alone versus hCG combined with clomiphene citrate, focusing on men with severely suppressed baseline FSH. METHODS...
  4. T

    Semen Analysis and trying to conceive, protocol changes

    Hi just received my semen analysis results and feeling a bit concerned. I’d love to hear the experience from other members in this group about conceiving while on TRT. A bit about me, 39 years old and have been on TRT for 5 years. Currently 14mg daily and HCG 500 IU 3 times a week. Was taking...
  5. madman

    PREDICTORS OF RESPONSE TO CLOMIPHENE CITRATE IN MEN WITH HYPOGONADISM

    * Randomized trials in obese hypogonadal men showed benefits including increased muscle mass, reduced fat, higher HDL, improved erectile function, and elevated TT. Older age (>55 years) was linked to reduced androgenic response. In late-onset hypogonadism, CC discontinuation led to relapse...
  6. D

    Finally coming OFF TRT - Nolvadex and Clomid question, I'm very scared.

    Hello guys, I was on TRT from mid 2022 to early 2024, had issues with ocasional ED and low libido so I decided to stop, it was self managed so I stupidly dont have bloods, quite possible i never neded the TRT at all. Came off in early 2024, using tamoxifen (2 months at a high dose of 20mg), i...
  7. Nelson Vergel

    HCG, Clomid & Fertility. START HERE (Index)

    Welcome to the HCG, Clomid & Fertility Forum! This index organizes our best resources to help you find what you need quickly. Whether you're preserving fertility on TRT, considering Clomid therapy, or planning PCT, start here. ▶ FERTILITY PRESERVATION & TRT Fertility Preservation on TRT: The...
  8. madman

    Hormonal Therapy for Male Infertility: Clomid, Gonal F, HCG, Letrozole for oligospermia and low sperm count

    Dr. Ramasamy! 10:24- 12:03 (Case report Isotretinoin) https://pmc.ncbi.nlm.nih.gov/articles/PMC12619667/ Clomid, Gonal F, HCG, Letrozole for oligospermia and low sperm count
  9. madman

    The complications of multi-drug TRT (hCG; AIs; SERMs; 5ARIs)

    All those dime a dozen run of the mill T-clinics! High dosed T off the hop with an AI thrown in to boot LMFAO! * He explains that medications such as anastrozole, hCG, clomiphene, and enclomiphene—tools used thoughtfully in academic urology for specific indications—are now often bundled...
  10. madman

    Clomiphene Citrate (Clomid) in Men With Low Testosterone - Do we Need to Monitor IGF-1 in All Patients?

    Is Clomid (clomiphene citrate) a good alternative to TRT for men with low testosterone? Clomiphene can raise testosterone levels while preserving fertility—making it attractive for younger men who want to avoid testicular shutdown. But new research suggests we should be monitoring IGF-1 levels...
  11. madman

    Clomiphene or enclomiphene citrate for the treatment of male hypogonadism: a systematic review and meta-analysis of RCTs

    https://www.aem-sbem.com/article/clomiphene-or-enclomiphene-citrate-for-the-treatment-of-male-hypogonadism-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials/ ABSTRACT Objective This study aimed to evaluate the efficacy and safety of selective estrogen receptor modulators...
  12. J

    Clomid (clomiphene), where and price?

    Where can you get Clomid (clomiphene) through a telemedicine/online and what price? My numbers are in the 400s but my local doctor only likes TRT, which I do not want to do. I'd rather start with Clomid 25mg. Ro has it but I'm seeing people say prices run $100-160 per month. You can have...
  13. madman

    Fertility-Focused Testosterone Therapy: Comparing hCG, Clomiphene, and TRT Strategies for Men

    * Use of hCG+TRT suppressed LH and FSH (p<0.05), whereas CC+TRT was associated with reduction in FSH only (p=0.02). However, at 6 months, CC monotherapy was associated with significant increases in LH and FSH (p<0.001). As expected, all three treatments were associated with substantial increases...
  14. madman

    Effects Of Clomiphene Citrate On Plasma T In Male Veterans With Central Hypogonadism With And Without Previous Treatment With Exogenous T

    Author Block: Sherman Mitchell Harman, MD, PhD1, Gurbir Gill, MD1, Garineh Ovanessoff, MD, MPH2, Gaja Andzel, MD3, JOHN MARCHETTE, PA4. 1Phoenix VA Health Care Syst, Phoenix, AZ, USA, 2Dignity Health/ St. Joseph's Hospital, Phoenix, AZ, USA, 3Be Well Endocrinology and Functional Medicine, Loma...
  15. madman

    Clomiphene for the Treatment of Testosterone Deficiency: Effects on Pituitary Axis Function

    https://pmc.ncbi.nlm.nih.gov/articles/PMC12544852/pdf/bvaf149.2003.pdf Author Block: Ashley Kieran Clift, Jeff Foster, David R. Huang. Manual (Menwell Ltd), London, United Kingdom. Disclosure Block: A.K. Clift: I am an employee of Manual (Menwell Ltd), a healthcare provider that provides...
  16. madman

    Breakthrough in Male Infertility: Can Clomiphene Boost Sperm Count and Natural Conception? Results from the CONCRETE Double-Blind Trial

    * The findings will be published in medical journals and international conferences. The results will be shared with the NHS repurposing programme to review Clomiphene licence. We devised a PPIE strategy, lay communication strategy, and established strong links with relevant charities to promote...
  17. madman

    Clomiphene vs. Anastrozole: Which Boosts Sperm Count and Fertility in Oligoasthenozoospermia?

    Oligoasthenozoospermia refers to a male infertility condition marked by low sperm count and reduced motility. The authors begin by noting that empirical therapies—like clomiphene and anastrozole—are often used for idiopathic (unknown cause) spermatogenic dysfunction, despite limited evidence of...
  18. Nelson Vergel

    Can Clomiphene / Enclomiphene Reverse Testicular Atrophy? Review of Limited Data.

    Below is a synthesis of what the literature presently shows about clomiphene (and its trans-isomer enclomiphene) and reversal of testicular atrophy in men. What hard data exist? Setting Study design (n) Testicular-volume result Time to observation Secondary hypogonadism, enclomiphene 25...
  19. Nelson Vergel

    Clomid (Clomiphene) Reduces IGF-1, a measure of Growth Hormone

    Summary of Study Findings: "Reduced IGF-1 Levels Following Clomiphene Treatment for Male Hypogonadism" (Journal of the Endocrine Society, 2025) Objective: To investigate whether clomiphene citrate—a selective estrogen receptor modulator used off-label to treat male hypogonadism—affects serum...
  20. madman

    Impact of Clomiphene Citrate Therapy on Lipid Profiles in Men with Hypogonadism

    * Labs collected include total testosterone (TT), free testosterone (fT), estradiol (E2), hematocrit (Hct), hemoglobin (Hg), triglycerides (TG), total cholesterol (TC), high density lipoproteins (HDL) and low density lipoproteins (LDL). Labs were collected before 11am, fasting, using LCMS and...
  21. madman

    When Treatment Backfires: One in Four Men on Clomiphene Citrate Experience Decline in Sperm Count

    * Data from 166 men seeking first medical help for primary MFI with low sperm counts who were prescribed CC 50 mg QD, with a second semen analysis available at follow-up after treatment initiation, were analyzed * CC effectively increases both sperm concentration and total testosterone levels...
  22. madman

    Age, Baseline LH, and Testicular Reserve: Predicting Clomiphene Citrate Success in Men with TD

    * In men with TD, lower LH levels and higher TT levels were a predictors of CC response. Clinicians can incorporate this into their treatment discussions with patients with TD. https://academic.oup.com/jsm/article/22/Supplement_4/qdaf320.156/8375133 PREDICTORS OF CLOMIPHENE CITRATE...
  23. M

    Finally Making the switch from Clomid to Enclomiphene

    Hey guys just wanted to update you on my clomid journey. For 2 years I was on clomid, my numbers were pretty dang good and I responded well. Check out my other posts more detail there. Up until this year tho I did start to feel kinda off. My sex drive was always really good but my mood was off...
  24. M

    Updated Clomid with labs

    I usually dont post labs since its so individual but I have been responding to clomid very well and have been on for two years. My total is around 1100/1200 and my free is right at the top of the range. My estrogen to test ratio has been pretty consistent for the last two years up until my most...
  25. madman

    Prescription Strategies for Clomiphene Citrate in Male Hypogonadism and Fertility Management

    ABSTRACT Clomiphene Citrate (CC), a selective estrogen receptor modulator, represents a valuable therapeutic option for addressing male hypogonadism and infertility. This article reviews practical approaches to CC prescription, emphasizing its use both as monotherapy and in combination with...
  26. M

    Long Term Clomid use experience

    Hello everyone, I am posting this simply to share my experience and would love for anyone to share theirs. I have been on clomid for almost 2.5 years now straight. I take 100 mg a week so 50 mg every 3 days. I have used 0 anabolics and I am 27 years old. My numbers have been fantastic. 1200...
  27. madman

    C

    @Nelson Vergel Issue starting new thread? Had this happen back in Dec. 2024 and it is happening again. Hopefully admin can look into this when he has time, thanks.
  28. O

    TRT induced Azoospermia fertility protocol question

    Hey guys, I’m a 30-year-old male who was on testosterone replacement therapy (TRT) for eight years. I’ve been completely off T for four months now and have been taking Clomid 25 mg daily and HCG 1,500 IU every Monday, Wednesday, and Friday. Recently, I’ve just increased my HCG dosage to 2,000...
  29. M

    ADHD Medication and Testosterone

    WARNING- LONG READ From the age of 17-21 I was taking short acting Focalin which is similar to ritilin. I did find my appetite to go down however my metabolism was sped up so I would really have to force the food when trying to put on muscle. I think these meds are terrible for muscle growth...
  30. M

    Clomid and Low IGF1

    I have been on Clomid for about a year and half. I have responded super well and my numbers continue to look good. I got my IGF-1 levels checked and they were pretty low. I am looking into some peptides to increase the GH. I am sure I am not alone, curious on your experience alongside the clomid...
  31. L

    21 y/o male dealing with low T before and after bilateral varicocelectomy

    I’m dealing with weird case of low T. Testosterone currently is 250 and free T is 36.5. I had grade 3++ varicoceles that I got removed this past August. Testosterone was also low then at 222 and 297 for two tests which was on of the two reasons I got them removed. LH is 4.3 and FSH is 9.1. Now...
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