depression

Interview with Husseini K. Manji, MD, author of The 25-Year Evolution of Lithium as a Disease-Modifying Agent in Dementia: A Narrative Review. Hosted by John Torous, MD.

Discover how a single high dose of psychedelic medicine impacts the neurological framework of individuals without pre-existing clinical conditions. This video breaks down a recent clinical trial evaluating psilocybin effects on healthy adults to understand its acute and long-term impact on the...

Do you know how to use assessment tools to guide treatment decisions for your patients with depression? Listen to learn more.

* Overall, the available evidence suggests that TRT may provide clinically meaningful improvements in mood for hypogonadal men, particularly those with low baseline testosterone and coexisting depressive symptoms. However, current data do not support its routine use as an antidepressant therapy...

* It is hypothesized that: ED is in part from SSRI-induced increased intracavernosal oxygen radical formation causing diffuse erectile tissue fibrosis; and reduced sensation/orgasm/libido is from SSRI-induced altered CNS neuron, synapse and neurotransmitter function. Informed consent prior to...

The psychedelic drug development landscape has reached an inflection point in early 2026, with Compass Pathways achieving the first positive Phase 3 psilocybin trial results in June 2025, while Lykos Therapeutics' MDMA rejection has reshaped industry expectations for regulatory rigor. Six...

The statement, “That ‘drug’ already exists—and it’s strength training,” highlights the extensive and potent health benefits of resistance exercise, often described in medical literature as a form of "miracle drug" due to its wide-ranging positive effects on nearly every bodily system...

Is nitrous oxide the next breakthrough for treatment-resistant depression, or do the subjective effects merely mask the symptoms? F. Perry Wilson, MD, analyzes a new meta-analysis suggesting "laughing gas" could be a viable treatment for major depressive disorder. The discussion explores the...

This article from The Art of Manliness addresses how erroneous thought patterns contribute to feelings of misery and negativity, drawing heavily on the work of psychologist David Burns, a key figure in cognitive behavioral therapy. The text outlines eleven cognitive distortions that make people...

Something is happening to men, and no one is talking about it. Child attachment and parenting expert Erica Komisar reveals how modern society is rapidly stripping men of their traditional roles, leaving many feeling lost, directionless, and disconnected from both their families and their...

In this episode of Better Edge, Brandon Hamm, MD, discusses an evidence-based approach to ketamine therapy, including patient selection, safety protocols and a newly expanded infusion suite. He compares ketamine with TMS and ECT, addresses common misconceptions and highlights training...

* drug induced DIPPER RIDE Has mental health treatment become a Religion rather than a Science? This talk explores the difference between Treatment with pills or therapies and a Care which pays heed to someone who has a problem or has a story to tell. Is there something wrong in this...

https://www.cambridge.org/core/journals/psychological-medicine/article/comparative-efficacy-and-tolerability-of-nutraceuticals-for-depressive-disorder-a-systematic-review-and-network-metaanalysis/5799A126D0B5677764562824C452D545 Abstract Background Nutraceuticals have been taken as an...

Are you a healthcare professional looking to deepen your understanding of the latest depression treatment strategies? Join us on The Curbsiders as Dr. Matthew Frankwato and Dr. Paul Nelson Williams welcome back renowned guest Dr. Jesse Gold to discuss advanced topics in managing...

Ibogaine is rapidly garnering attention as a potentially revolutionary treatment for addiction and related mental health disorders—a beacon of hope in landscapes often characterized by despair and systemic inadequacy. In a recent Fluence webinar, leading experts Dr. Bruno Rasmussen (Brazilian...

* Psychedelics are not panaceas, but they offer mechanisms of action distinct from conventional treatments. Substances such as MDMA, psilocybin, ibogaine, ketamine, and 5-MeO-DMT are demonstrating the capacity to disrupt entrenched neurobiological patterns associated with trauma, addiction, and...

Nick Fortino and renowned psychiatrist Dr. David Healy look at modern psychiatry and psychopharmacology. Dr. Healy, a vocal critic of the pharmaceutical industry's influence, exposes how the "serotonin myth" emerged from marketing, reveals how antidepressants (SSRIs) can blunt emotions and cause...

“What [we] found was that those men who received a penile implant had a significant reduction in depression and psychological distress," says Mohit Khera, MD, MBA, MPH. https://www.urologytimes.com/view/mohit-khera-md-on-the-impact-of-penile-prosthesis-implant-on-mental-health...

A nasal spray that uses a form of ketamine to treat stubborn depression will be added to the PBS, making treatment cheaper for thousands of Australians.

https://pmc.ncbi.nlm.nih.gov/articles/PMC8514700/ https://pmc.ncbi.nlm.nih.gov/articles/PMC8964433/ "Several studies show that the level of acylcarnitines (ACs) changes significantly in patients with depression compared with healthy controls while the supplementation of acetyl-L-carnitine is...

Discover how ketamine, a well-established anesthetic, is gaining attention for its medical applications in anesthesia, pain management, and the treatment of psychiatric conditions. Learn about its method of action, interactions in pain pathways, and its use in managing treatment-resistant...

In this thought-provoking episode of the Carlat Psychiatry Podcast, Dr. Chris Aiken sits down with Dr. David Healy, a renowned psychopharmacologist, to discuss the current state of psychiatric medications and their impact on clinical practice. Dr. Healy, a leading critic and practitioner of...

Hello, has anyone here experienced heart palpitations, fatigue, low energy, muscle pain, or depression because of hormone imbalance?

Dr. Roy Perlis is the director of the Center for Quantitative Health at Massachusetts General Hospital and a professor of psychiatry at Harvard Medical School. Stephen Morrissey, the interviewer, is the Executive Managing Editor of the Journal. J. Kim and Others. Esketamine for...

Depression and Testosterone: Unraveling the Complex Relationship Lecture By Dr. Mohit Khera Depression is a pervasive mental health condition affecting millions globally, with its interplay with physiological factors like testosterone levels garnering increasing attention. Understanding this...

Been on trt for 4 years now. Testosterone level 522, estradiol at 36. dosing EOD 90mg a week. I have been developing depression and anxiety more than usual last 3 months. I was also on 400iu of HCG i9n the past but discontinued as it made my anxiety worse. I was wondering if I should be asking...

Many people who stop taking SSRI antidepressants experience what is often described as “protracted withdrawal syndrome.” In this webinar, David Healy presents a different understanding of the biology of this injury: people withdrawing from SSRIs are suffering a “dysregulation” of their sensory...

The Psychopharmacology Institute is an online platform offering unbiased, practical psychopharmacology updates for healthcare providers, with content updated monthly. It also presents opportunities to earn CME and SA credits. This video lecture explores the evidence of N-Acetyl-Cysteine (NAC)...

Helen Mayberg at the BrainMind Special Forum in Neuromodulation/BCI/AI, interviewed by BrainMind member Jane Roskams. Helen Mayberg is the Director of the Nash Family Center at Mount Sinai for Advanced Circuit Therapeutic, Professor of Neurology, Psychiatry, Neuroscience and Neurosurgery. The...

Glad he acknowledged Post-SSRI Sexual Dysfunction (PSSD)! How Can Depression Affect Your Sex Drive? Dr. Daniel Watter answers this question in the latest installment of this video series.