depression

This lecture given at a Medicating Normal meeting outlines a radical new view about what Antidepressants do and don't do. It covers issues that need input from everyone on how best to move forward with these treatments. The slides and text can be found on RxISK.org in a post called Fantasies of...

In this third episode of a four-part Double Take video miniseries on depression from the New England Journal of Medicine, Drs. Sanacora, Nikayin, and Cristancho discuss the role neuroplasticity may play in the pathogenesis of depression and the benefits to patients of advanced therapies for...

In this second episode of a four-part Double Take video miniseries on depression from the New England Journal of Medicine, Drs. Anderson, Teel, and Scott-Vernaglia discuss available treatments for depression, including psychotherapy and first-line and second-line antidepressants. Dr. Sanacora...

In this first episode of a four-part Double Take video miniseries on depression from the New England Journal of Medicine, Dr. Scott-Vernaglia recounts her personal experiences with depression. She and Drs. Sanacora, Crawford, Teel, and Anderson discuss the prevalence of depression and the need...

This might seem stupid, but here me out…. Long story short: I have treatment/lifestyle/therapy resistant depression, mental fatigue, anxiety. You name it, I’ve tried it. Believe me. Both medical and underground. Doctors are at a loss. But one day I decided to try testosterone and….. bam. Total...

Fasedienol (PH94B) Nasal Spray is a safe fast-acting and odourless neuroactive steroid https://www.vistagen.com/pipeline/PH94B/overview Fasedienol (PH94B) Nasal Spray for Social Anxiety Disorder Vistagen’s fasedienol (PH94B) is a first-in-class, rapid-onset investigational neuroactive...

00:47 Update on Bipolar Depression and Antipsychotic Spectrum Bipolar depression treatment algorithms have evolved significantly over the years. Recommendations for treating bipolar depression have changed multiple times since 2001. The Department of Psychiatry receives many inquiries about...

Although the sole unequivocal indication for testosterone treatment is replacement therapy for male hypogonadism, off-label testosterone prescribing for aging men without pathologic hypogonadism rose dramatically (100-fold) over recent decades including 10-fold increases in the USA and 40-fold...

Psychedelics have helped me and many others that I know through real dark times of addiction and depression. My own breakthrough with psychedelics provided the breaking down of my belief systems and reawakened an overwhelmingly empowering sense of my own ability to change. I’m super excited...

https://www.hcplive.com/view/ketamine-for-the-treatment-of-mdd Ryan Oakley, MD, takes a closer look at the recent history of ketamine in depression. He also explores the differences between ketamine and esketamine.

Nandrolone is literally the only thing (so far) that helps me manage shoulder pain due to my cervical radiculopathy. But even at low doses (~60 mg a week), I seem to get very depressed on it, and feel "flatlined" about life in general. Good news is that even at 60 mg it helps immensely. I've...

Thought I would start a discussion about this awesome lesser known peptide, yet one of the peptides with quite a few actual human studies behind it. So I'll start with my experience before getting to the science: I have done a few cycles (they last 5-7 days of 8-10 mg) of it this year and...

Finasteride and dutasteride, synthetic 5α-reductase inhibitors (5ARIs) are recommended in many guidelines for the treatment of benign prostatic hyperplasia/lower urinary tract symptoms and alopecia despite a variety of side effects like sexual, neurological, psychiatric, endocrinological...

SUMMARY The transition to menopause and early postmenopausal years may be quite challenging for some women, with the increased risk for developing depressive symptoms (new, recurrent) and anxiety, along with vasomotor complaints, sleep problems, and other menopause-related health conditions. It...

Has anybody been able to overcome brain fog from ptsd and depression? If so how did you do it? What helped the most? How did you get your energy back and ability to focus? Thank you

https://whatyourgpdoesnttellyou.podbean.com/e/dr-david-healy-discusses-ssri-drugs-suicide-and-sexual-dysfunction/ Dr. David Healy was one of the first psychiatrists to suggest that while in some cases the antidepressant drugs, the SSRIs may help prevent suicide, in other very rare cases...

11:00-11:34 *leading on from the emotional numbing thing the single commonest thing any of these SSRIs drugs do is to genitally numb people, within 30 minutes of your first pill people will be to some degree genitally numb, a small number will be genitally irritable but for the most part...

I have been treating with multiple medications for depression for the past 4 years. I began TRT 18months ago after having my prostate removed due to cancer. in reading in this forum, I see that most men report their motivation and sense of well being improve while on TRT. Although THT has...

The role of testosterone, the androgen receptor, and hypothalamic-pituitary-gonadal axis in depression in aging Men (2022) Richard L. Hauger · Ursula G. Saelzler · Meghana S. Pagadala · Matthew S. Panizzon Abstract Considerable research has shown that testosterone regulates many physiological...

So I have been feeling pretty crappy lately (down depressed anxious and no libido) and decided to do labs. I had labs done and my t was -1319 E2 sensitive was - 31 Shgb- 42 Free T was 29 But the weirdest one was my dht it came in at 50pg/ml. Which is incredibly low. What makes no sense is I’m on...

Good evening, everyone. I figured I'd make a thread documenting my progress. Hopefully the information and ensuing discussions contained herein could provide assistance for others down the line, as others' threads had provided for me. I also have some questions which will be added at the end, so...

https://msutoday.msu.edu/news/2022/understanding-the-role-of-testosterone-in-depression MSU received a $3M NIH grant to study the hormone’s effects on brain circuitry Major depressive disorder affects women twice as often as men, but researchers are still trying to identify the reasons why...

I decided to create a new thread to compile some of the evidence against the use of antidepressant drugs to treat depression. In my mind, the most compelling reason to avoid them is that they may worsen the condition over time, so we will begin there. The following paper suggests poor-long...

I added nandrolone officially to my regimen about one month ago (I have tried it in the past but never very long). The purpose of adding it was to assist in resolving joint pain, and it works PERFECT!! 10 out 10, joint pain is nearly non-existent! I am doing physical therapy in addition...

Nitrous Oxide: an emerging novel treatment for treatment-resistant depression (2022) Darin F. Quach, Victoria C. de Leon, Charles R. Conway ABSTRACT Stemming from the results of the historic STAR-D trial, it is evident that a significant subset of individuals (20–25%) with major depressive...

It is often assumed that the effects of antidepressants demonstrate that depression must be at least partially caused by a brain-based chemical abnormality, and that the apparent efficacy of SSRIs shows that serotonin is implicated. Other explanations for the effects of antidepressants have been...

Pharmacological Treatments for Anhedonia (2022) Matthew E. Klein, Ariela Buxbaum Grice, Sahil Sheth, Megan Go, and James W. Murrough Abstract Anhedonia – the reduced ability to experience or respond to pleasure – is an important symptom domain for many psychiatric disorders. It is...

A new preclinical drug reported by James Bibb, Ph.D., and colleagues has the potential to combat depression, brain injury, and cognitive disorders. The drug, which is notable for being brain-permeable, works by inhibiting the kinase enzyme Cdk5. Cdk5 is an important signaling regulator in...

I’ve spent the better part of the last 2 years struggling with persisting ED, Depression, Anhedonia following the use of Boldenone and then Primobolan. My symptoms align mostly with what a lot of people with PFS have but given I’ve never had PFS I’m reluctant to post on the propeciahelp forums...