Trimix

Trimix is a compounded injectable medication containing alprostadil, papaverine, and phentolamine, used to produce reliable erections when PDE5 inhibitors like Cialis or Viagra stop working. It is injected into the side of the penis using an insulin syringe, typically producing an erection within 5 to 15 minutes that lasts 30 to 90 minutes depending on dose. Threads in this tag cover starting doses, titration, injection technique, side effects such as priapism and scar tissue, sourcing from compounding pharmacies, and how men integrate Trimix with TRT protocols.
  1. J

    Urgent question about Trimix

    Did my first shot of trimix, nothing, second shot the same. 5 Units, then 7 Units, now third time 10 units and I finally felt something. By units I mean UI's. I never got that super rock hard erection but it was pretty good. However, after cumming I'm now on hour 3.5 with a semi, VERY slowly...
  2. phalloguy100

    Trimix / Edex injection questions

    I have tried Edex and Trimix, with better results on a smaller dose of Trimix. I use an auto injector, and try to do the 1-3 o'clock position. Here's my problem: too many surface veins everywhere!! I think you're supposed to inject closer to the base of the penis, but I often have to go...
  3. Nelson Vergel

    What is the latest treatment for erectile dysfunction?

    A Comprehensive Guide to Current and Emerging ED Therapies for Men Curated By Nelson Vergel | ExcelMale.com | Updated January 2026 Introduction: Why ED Treatment Is Evolving Are you struggling with erectile dysfunction despite trying oral medications? You’re not alone. An estimated 322 million...
  4. T

    Trimix.. how has it worked in shower or pool, jacuzzi or hot tub?

    Hello, I am so thankful for this forum. I 46 years old and about to set off into the trimix world. This forums have helped me because I was a bit afraid when my doctor suggested it as I am type 1 diabetic. My question is is trimix as effective in water settings? Pools, showers, jacuzzi etc ? Thanks
  5. madman

    Mastering Intracavernosal Injection for Men’s Health: Test Dose Protocols, Titration, and Real-World Tips With Leading Experts

    Nelson's Excel getting deep as usual! Pay close attention Q&A: (53:29-55:00) Can patients become immune to Trimix and therefore need to increase their dose over time? * Absolutely, this is a known quantity with Trimix, when I counsel a guy about intracavernosal injections what I'm usually...
  6. S

    Damage to my penis... please help

    Hi guys.. I've had ED for years. I was prescribed trimix and misused it by injecting myself multiple times in one session which I know was extremely stupid but I was desperate cuz I couldnt find my dosage and didnt want to disappoint my gf. This happened in May last month. I shouldve tested it...
  7. madman

    Clinical Sexologist Explains How to Use Erectile Dysfunction Injections – Step-by-Step Guide for Men with use of an Auto-injector

    * now the most important thing about these insulin needles is you need to have a long needle, so these ones are 12.7mm long (1/2") which is really important In this clear, no-nonsense tutorial, Nurse Practitioner and Clinical Sexologist Melissa Hadley Barrett walks you through everything...
  8. C

    First time with Trimix, my experience

    Hi everybody, thought I'd share my experience with Trimix . For the first time ever since the Dopler ultrasound over a decade ago, I took Trimix. Purchased from a compound pharmacy here in Montreal area, with a prescription from my urologist. $105 for 5 ml. Yesterday I accidently injected...
  9. B

    Looking for advice regarding trimix use

    Hi, Hoping some of the other members here will be able to help. Short overview, I'm 45, been dealing with ED and loss of libido for 12 years. Done all the tests, had TRT several times in every form, no change. Viagra and Cialis did not work, pumps and rings only minimally with much discomfort...
  10. F

    Trimix gel

    Does anyone have experience with Trimix gel? I'm curious to know if it works just as well as the injectable form?
  11. D

    Storing Trimix

    First time Trimix user (if I don’t chicken out). Received it a few minutes ago. It says to put it in freezer. Looking here and elsewhere online, I’m seeing about 70% saying refrigerate and 30% saying keep frozen. If I freeze, won’t that necessitate thawing? And refreezing, which is a no-no...
  12. madman

    27 Questions + Answers about TRIMIX Penile Injection Therapy for ED

    In this webinar, Dr. Roger Khouri, Urologist, reviews dosing, proper injection technique, and safety, and answers all of your questions about Injection Therapy for erectile dysfunction. In this webinar, Dr. Khouri discusses: - Injection Medication - Syringe and Dosing - Injection Techniques -...
  13. D

    Trimix "burn" for the Misses

    For the Trimix users here... has anyone had any complaints from the "partner" complaining about a burning sensation during sex? (...and no it's not a STD lol). I'm 99% sure it's the alcohol swipe I use to prep the injection site. Assuming that's the cause...any ideas on if there is something...
  14. Nelson Vergel

    Sexual Dysfunction Lecture by Nelson Vergel- Video and Summary

    00:00 - 10:10 The speaker discusses sexual dysfunction in men and women, focusing on erectile dysfunction. The lecture covers various causes and risk factors for erectile dysfunction, including age, cardiovascular disease, diabetes, and psychological issues. The speaker also discusses the...
  15. madman

    Delineating patient errors in an intracavernosal injection program

    Abstract Background Intracavernosal injection therapy (ICI) is a well-established therapeutic strategy for men with erectile dysfunction. Complications are often related to patient error when performing ICI. Aim The objective of this study was to examine patient errors in an established...
  16. W

    Trimix and sleep disruption

    I've noticed that even with smaller doses, e.g. 5 units, Trimix will heavily disrupt my sleep for about three nights. I will wake up in the middle of the night and can feel what seems like elevated blood pressure. If I am on my side I can hear the blood rushing through my veins. It's not...
  17. B

    First experience with BiMix

    I have posted about my experience withTriMix, so I thought I would follow up with this post about my switch to BiMix. The TriMix gives me extremely hard and slightly painful erections. And even at very small doses...1-2 units...I will be hard for 2+ hours. So I recently tried BiMix for the...
  18. J

    New Trimix Prescription Online?

    Does anyone know of an online clinic where new prescriptions of lyophilized Trimix can be obtained? I have used Trimix for about eight years. I moved to another city and my Uro wants to see me in person before he will write a new prescription. It would be great if I could do that online with...
  19. G

    Trimix "Missing Corpa Cavernosa" - No Effect

    So I am still learning this and only my 3rd time attempting to use Trimix. First two times were successful, this time though, was not. I injected and waited the 15-20 minutes with no changes. I had read that it was possible to miss the main canal that your supposed to put it in, so I...
  20. G

    Trimix Usage vs. Recommendations

    To be up front I am going on a bit of a adult getaway with my wife here soon where we will be at a romantic cabin for 5 nights. Now I know when I got Trimix (mind you I have only used it twice now) there were a number of warnings, such as no more than 3 times in a week, always alternate sides...
  21. G

    First Time User of Trimix, recommended 50 Units! I'm worried

    I've been going through countless forums and reading what people have said about what they dose, and hearing horror stories of doses as low as 10 units putting people in the ER, and yet I'm told to dose 50 Units having never used it before ever. Seeking advice on how to proceed, I don't yet...
  22. T

    Trimix not working

    I used to use Trimix with good success. I stop using it for a while, but the next time I started using Trimix, it didn't work as well, even when I increased the dose. I did start taking some new herbs and vitamins. I was wondering if anybody knows of any herb or vitamin that can impact the...
  23. madman

    How To Inject Trimix for Erectile Dysfunction

    Erectile dysfunction (ED) is a common condition that affects many men at some point in their life. Penile injections are one of several options if other treatments fail, or for men who are unable to take ED oral medication. Urologic surgeon Petar Bajic, MD, explains the technique for safe use of...
  24. B

    Trimix Topical Gel? Anyone heard of this yet?

    https://trimixgel.com/ Recently stumbled on this... Anyone know anything about it? Shockingly almost 0 info about it on google. EDIT: Looks like its not topical - but still a much better method of use...
  25. B

    Using TriMix WHILE already erect?

    Wondering if anyone has injected TriMix while they already had an erection? If so, how did it go?
  26. B

    Combining Trimix and Cialis report

    I tried TriMix a week or so ago for the first time. I was/am still afraid of it, so I started with only 3 units. And am VERY happy I did only 3 units because I “responded well” to that little amount. Back story for those who have not read my past posts, is I do it have a problem getting hard...
  27. madman

    Penile Injections Expert | FAQS

    Summary In this video, sexologist and nurse practitioner Melissa Hadley Barrett discusses penile injection therapy and its benefits for men post-prostatectomy. She addresses common questions about the therapy, including its effectiveness for nerve recovery and the difference between injections...
  28. D

    Side Effect Should Prompt New Research

    https://www.mirror.co.uk/news/world-news/supermarket-evacuated-over-fears-highly-30673037.amp Spider venom may be the new Trimix.
  29. G

    trimix not working as well as it did

    Hi all Been using trimix silver for 10 years had to increase dose periodically up to .8, doc moved me to the trimix red and its doesnt seem to work as well. He advised starting at .4, im up to .5 And have mixed results. Sometimes it works great sometimes just ok. Also notice the tip of my penis...
  30. R

    Does trimix help with sensitivity

    I can have an erection but it won't feel so pleasurable during sex. I tried Viagra cialis but they don't help with sensitivity. They made it worse. Did anyone find that it helped with sensitivity where you're penis doesn't feel like your finger?
  31. W

    Trimix injections, Fusion back surgery and Eliquis

    Has anyone had any experience with Trimix injections while on Eliquis? Had a DVT following lumbar fusion (ALIF) and on Eliquis currently. While ED improved considerably after HOLEP (Sept 22), dealing with major back surgery recovery (March 23) has made the ED worse again. Hematologist wasn't...
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Trimix

Trimix Trimix is a compounded injectable medication containing alprostadil, papaverine, and phentolamine, used to produce reliable erections when PDE5 inhibitors like Cialis or Viagra stop working. It is injected into the side of the penis using an insulin syringe, typically producing an erection within 5 to 15 minutes that lasts 30 to 90 minutes depending on dose. Threads in this tag cover starting doses, titration, injection technique, side effects such as priapism and scar tissue, sourcing from compounding pharmacies, and how men integrate Trimix with TRT protocols.

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