Advice on TRT lab levels - high estradiol and hematocrit

Lance69

Member
I'd appreciate any advice on my labs.

I am on the Crisler protocol. 25 units HCG on Tues Wed, .8cc Test cyp 200mg/ml on Thurs.

Low libido wood issues persist.

My Labs - pre Thurs testo shot:

RBC - 6.58
Hemoglobin - 19.5
Hematocrit - 60.0
Testosterone - 700
Estradiol - 54.1
PSA - 1.9

Thanks to the resident experts for any input.
 
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I would lower my T to 100 mg per week, keep the hCG at 250 IU twice per week, and get therapeutic phlebotomy. Even with one blood donation, your hematocrit will still be high at 56-57. I would wait a month to do another blood donation.

Stay hydrated and take a baby aspirin.

Your estradiol is not high, specially if it was tested using the old test assay (not sensitive).
 
Thanks Nelson. I've done a lot of digging on this and want to try the following and redo labs in a few weeks.

Mon - .4cc test cyp
Tues - HCG 250 iu
Wed -
Thurs - .4 test cyp
Fri - HCG 250 iu
Sat -

Then I will likely scale back on the T shots little by little based on the labs. Thoughts?
 
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Why the letrozole? Many guys regret having taken it.

Was your E2 measured by sensitive analysis ( LC/MS) ?
My dr recommends Letro. Maybe now that I will start to reduce my T and go to twice a week I won't need the Letro. He was trying to bring down my E2 with it, but you think reducing my T and going to 2x a week might correct the E2 and libido issues, so I will try that for a while without the Letro and see how I do.

Many thanks Nelson.
 
Thanks Nelson. I'm going to follow your guidance and make some adjustments to my schedule using chatgpt. I'll stay on this for a while to see how my estradiol and hematocrit do.

Any input welcome.

trt.hcg.schedule.webp
 
I'm feeling much better on this regimen of reduced T and dividing my shots into 2 per week rather than 1. I've gone from 8cc one shot, to 7 one shot, to 3.5 two shots, to 3.1 two shots. I will gradually go down to 2.5 two shots to see how I do. Still using HCG Pregnyl 200 units 2 x per week per my chart. Some think more is better, but it's not.

The reduced amounts got rid of my headaches and I have morning wood again. I bet my E2 is much improved. Hoping my high hematocrit too. I look forward to my next labs to see where I'm at.
 
It's amazing how much better I feel now that I have reduced my T shots .8cc to .6cc and divided it into 2 shots per week of .3cc. I also reduced my HCG to 200 units, from 250.

I always thought more would be better but I was wrong.

When I first got on TRT, my urologist gave me one monthly injection of 3.5cc! OMG. He was clueless.
 
I always thought more would be better but I was wrong.

When I first got on TRT, my urologist gave me one monthly injection of 3.5cc! OMG. He was clueless.
Hey, @Lance69
I always thought more would be better but I was wrong.

When I first got on TRT, my urologist gave me one monthly injection of 3.5cc! OMG. He was clueless.
Greetings,@Nelson Vergel @madman @Lance69 interesting post I've been on Xyosted 75mg once a week injections I did not start out there 50 mg upon startup. Im not doing HCG yet but my last blood results from Quest are TT 705 (5 days after injection injections are on Wednesdays so I am close to trough) FT-100.7 E2- 47 skipped the anastrozole for 3 weeks my e2 was running high. Hemoglobin 17.9-high and Hematocrit 53.4 High. I have not donated since December 2025. I currently taking a one week holiday off the Xyosted injection per Dr. instructions and will donate after the weekend. My E2 runs high not as concerning but the Hematocrit is and cannot seem to get this under 50. I stay hydrated also. I do not like the donation train either but I will go next week my iron falls after donation and ferritin. I would say that I am a hyper responder to Test.

I am looking for any advise and suggestions that could help lower the Hematocrit? I have been diagnosed with sleep Apnea (Mild) fixing to get CPAP to see if that will help bring it down.

Thanks to yall and "Reach Your Goals"
 
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I think some of us just have high hematocrit. I recall when I was young having a CBC done and my doc said everything looks great but you have a high hematocrit. So that was way before TRT. It never caused health issues with me. I just try to force water and take a baby aspirin at bedtime to prevent a dreaded nighttime clot.
Donation only lowers hematocrit 3 pts! But its still important to donate. Also keep the T to an acceptable range but not overdo it like I was.
 
Hey, @Lance69

Greetings,@Nelson Vergel @madman @Lance69 interesting post I've been on Xyosted 75mg once a week injections I did not start out there 50 mg upon startup. Im not doing HCG yet but my last blood results from Quest are TT 705 (5 days after injection injections are on Wednesdays so I am close to trough) FT-100.7 E2- 47 skipped the anastrozole for 3 weeks my e2 was running high. Hemoglobin 17.9-high and Hematocrit 53.4 High. I have not donated since December 2025. I currently taking a one week holiday off the Xyosted injection per Dr. instructions and will donate after the weekend. My E2 runs high not as concerning but the Hematocrit is and cannot seem to get this under 50. I stay hydrated also. I do not like the donation train either but I will go next week my iron falls after donation and ferritin. I would say that I am a hyper responder to Test.

I am looking for any advise and suggestions that could help lower the Hematocrit? I have been diagnosed with sleep Apnea (Mild) fixing to get CPAP to see if that will help bring it down.

Thanks to yall and "Reach Your Goals"
How many weeks were you injecting the 75mg protocol before your blood test?
 
How many weeks were you injecting the 75mg protocol before your blood test?
@Lance69 I do take a baby asprin in the AM upon waking up and slamming water down also. Does it matter what time of day to take baby aspirin AM or PM? My Hematocrit was in the normal range even with my first protocol of Netesto nasal gel x3 times a day and only when moving to Xyosted did it bring up Hematocrit over time. It also brought up my TT FT and E2 I do convert TT to E2 more than other men probably not sure but the anastrozole micro dose helps I just try not to do this on a weekly basis because I feel my joints and tendons hurt more but its inline and there. @Willyt my previous labs where done December 15, 2025 (my math is not that great), but approx. 4-1/2 months ago about close to 15 weeks and 3 days. between labs. Do you have any suggestions to lower the Hematocrit?

Thanks,
"Reach your Goals"
 
@Lance69 I do take a baby asprin in the AM upon waking up and slamming water down also. Does it matter what time of day to take baby aspirin AM or PM? My Hematocrit was in the normal range even with my first protocol of Netesto nasal gel x3 times a day and only when moving to Xyosted did it bring up Hematocrit over time. It also brought up my TT FT and E2 I do convert TT to E2 more than other men probably not sure but the anastrozole micro dose helps I just try not to do this on a weekly basis because I feel my joints and tendons hurt more but its inline and there. @Willyt my previous labs where done December 15, 2025 (my math is not that great), but approx. 4-1/2 months ago about close to 15 weeks and 3 days. between labs. Do you have any suggestions to lower the Hematocrit?

Thanks,
"Reach your Goals"

Greetings,@Nelson Vergel @madman @Lance69 interesting post I've been on Xyosted 75mg once a week injections I did not start out there 50 mg upon startup. Im not doing HCG yet but my last blood results from Quest are TT 705 (5 days after injection injections are on Wednesdays so I am close to trough) FT-100.7 E2- 47 skipped the anastrozole for 3 weeks my e2 was running high. Hemoglobin 17.9-high and Hematocrit 53.4 High. I have not donated since December 2025. I currently taking a one week holiday off the Xyosted injection per Dr. instructions and will donate after the weekend. My E2 runs high not as concerning but the Hematocrit is and cannot seem to get this under 50. I stay hydrated also. I do not like the donation train either but I will go next week my iron falls after donation and ferritin. I would say that I am a hyper responder to Test.


I am looking for any advise and suggestions that could help lower the Hematocrit? I have been diagnosed with sleep Apnea (Mild) fixing to get CPAP to see if that will help bring it down.

Thanks to yall and "Reach Your Goals"






Would have been wise to retest your TT and more importantly FT at the true trough (lowest point) before your next injection which would be 7 days post-injection seeing as you are using Xyosted (TE) which is injected once weekly strictly sub-q.

You would need to have your FT tested using the most accurate assay the gold standard Equilibrium Dialysis to know where it truly sits especially in cases of altered SHBG.

Otherwise you would need to use/rely on the next best testing method the most widely used go to calculated linear law-of-mass action Vermeulen (cFTV) which will give a good approximation.

You need to use the calculator which is available online for free to the general public but you need to plug in TT, SHBG and Albumin in order to calculate your FT.

Even though you are injecting sub-q which should keep your blood levels more stable throughout the week vs IM your true trough would still be lower.

5 days post-injection you are hitting a robust TT 705 ng/dL but hard to tell where the most critical fraction sits which is free testosterone as I have no idea what testing method was used and you never posted the reference ranges.

Do you have any idea where your SHBG sits?

Keep in mind even though you are hitting a robust TT 705 ng/dL 5 days post-injection your FT may not be that high if you have high SHBG.

I do not agree with stopping the injections for a week as the main issue here most likely contributing to your high hematocrit 53.4% which is still just shy of the cut-off 54% would be the obstructive sleep apnea.

Once you address the OSA which should be done ASAP it is pretty much a given your hematocrit will improve over time.

Please look over the threads posted below!




* Most current guidelines, including those from the American Urological Association and the Endocrine Society, flag hematocrit above 54% as a threshold requiring intervention. Some clinicians use 52% as a softer “watch and manage” threshold, particularly for men with additional cardiovascular risk factors.





Look over my replies in this thread too!

 
Would have been wise to retest your TT and more importantly FT at the true trough (lowest point) before your next injection which would be 7 days post-injection seeing as you are using Xyosted (TE) which is injected once weekly strictly sub-q.

You would need to have your FT tested using the most accurate assay the gold standard Equilibrium Dialysis to know where it truly sits especially in cases of altered SHBG.

Otherwise you would need to use/rely on the next best testing method the most widely used go to calculated linear law-of-mass action Vermeulen (cFTV) which will give a good approximation.

You need to use the calculator which is available online for free to the general public but you need to plug in TT, SHBG and Albumin in order to calculate your FT.

Even though you are injecting sub-q which should keep your blood levels more stable throughout the week vs IM your true trough would still be lower.

5 days post-injection you are hitting a robust TT 705 ng/dL but hard to tell where the most critical fraction sits which is free testosterone as I have no idea what testing method was used and you never posted the reference ranges.

Do you have any idea where your SHBG sits?

Keep in mind even though you are hitting a robust TT 705 ng/dL 5 days post-injection your FT may not be that high if you have high SHBG.

I do not agree with stopping the injections for a week as the main issue here most likely contributing to your high hematocrit 53.4% which is still just shy of the cut-off 54% would be the obstructive sleep apnea.

Once you address the OSA which should be done ASAP it is pretty much a given your hematocrit will improve over time.

Please look over the threads posted below!




* Most current guidelines, including those from the American Urological Association and the Endocrine Society, flag hematocrit above 54% as a threshold requiring intervention. Some clinicians use 52% as a softer “watch and manage” threshold, particularly for men with additional cardiovascular risk factors.





Look over my replies in this thread too!

@madman,

Question: Do you have any idea where your SHBG sits? Yes, 38 SHBG I am attaching the labs for the ranges. Also fixing to get a OSA machine soon. Hopefully, this will bring the Hematocrit down. Yes, Dr. instructions one week holiday off Xyosted and donation 1 pint of blood. Please tell me your basis for your
non agreement of the holiday. I will take your advise on the next lab work and get that done exactly on trough day instead of Monday it will be Wednesday Dr. suggested Monday for labs. Labs are done at Quest.
Thanks,
"Reach Your Goals"
 

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@madman,

Question: Do you have any idea where your SHBG sits? Yes, 38 SHBG I am attaching the labs for the ranges. Also fixing to get a OSA machine soon. Hopefully, this will bring the Hematocrit down. Yes, Dr. instructions one week holiday off Xyosted and donation 1 pint of blood. Please tell me your basis for your
non agreement of the holiday. I will take your advise on the next lab work and get that done exactly on trough day instead of Monday it will be Wednesday Dr. suggested Monday for labs. Labs are done at Quest.
Thanks,
"Reach Your Goals"
Like Madman said, get tested at true trough day 7 before injection.

I have same SHBG at 38-40 while on TRT. My hematocrit starts climbing quickly once my TT exceeds supraphysiologic levels.

Xyosted peak is 1.8x trough so my guess is your TT peak is well over 1000 - not crazy high, but high enough to push up your HCT. That same 75mg dose would peak me well over 1200+.
 
@madman,

Question: Do you have any idea where your SHBG sits? Yes, 38 SHBG I am attaching the labs for the ranges. Also fixing to get a OSA machine soon. Hopefully, this will bring the Hematocrit down. Yes, Dr. instructions one week holiday off Xyosted and donation 1 pint of blood. Please tell me your basis for your
non agreement of the holiday. I will take your advise on the next lab work and get that done exactly on trough day instead of Monday it will be Wednesday Dr. suggested Monday for labs. Labs are done at Quest.
Thanks,
"Reach Your Goals"

Good man you had your TT and more importantly FT tested through Quest using the most accurate assays.

Your FT was tested using the gold standard ED and as you can see 5 days post-injection your FT 10 ng/dL is not that high which means your true trough 2 days later will be lower as in falling in what would be called the grey zone 5-9 ng/dL.

As I have stated in some of your other threads and numerous times on the forum.

FT <5 ng/dL would be considerd low.

FT 5-9 ng/dL would be considered the grey zone where some men may experience symptoms of low-T.

FT 10-15 ng/dL would be healthy.

FT 20-25 ng/dL would be high-end/high!

The majority of men will do well with a trough FT 15-25 ng/dL depending on the injection frequency.

Yes your peak would be higher but even then it is not going to be absurdly high as you are injecting strictly sub-q using Xyosted (TE) and it is pretty much a given there will not be a huge swing in peak--->trough.

Even if your peak is sitting around 1000 ng/dL with a somewhat highish SHBG 38 nmol/L your FT would most likely fall in the high teens.

Again you are only hitting a FT 10 ng/dL 5days post-injection so your FT at the true trough 2 days later will be subpar as in fall within what would be the grey zone 5-9 ng where some men may experience symptoms of low-T.

Unless you truly feel great overall then stick with it but you would easily have room to bring up your trough FT if need be but unfortunately you are dealing with the elevated hematocrit let alone high estradiol which you were trying to control with an AI.

Of course it is a given that the exogenous T will drive up the hematocrit but highly doubtful that it is solely to blame here as your peak FT would not be very high and your true trough 7 days post-injection is most likely sub-par.

Again I would put most of the blame on your OSA!

Taking a week off and skipping your injection is not going to make a s**t lick a difference for addressing the elevated hematocrit as your T levels would need to be brought down long-term especially seeing as it will take time for your hematocrit to drop due to the life cycle RBCs which is 120 days!

As you would know donating is just a temporary fix.

If ones hematocrit was elevated to the point where it needed to be addressed and was strictly due to having too high a trough/steady-state FT than the fix here would be lowering the weekly dose and bringing down your trough FT but this is not the case here as your main issue would be the OSA not your trough FT being too high.

I would not even waste your time skipping a weekly injection.

The more sensible move would be donating then get on that CPAP ASAP!.

Once you address it your hematocrit will come down over time.
 
With Nelson's advice my new TRT is:
MonWedFri - 0.2cc test cyp

TuesThursSat 150units Pregnyl HCG

Sat night sex - 2g Citrulline 4 hrs prior, 5mg cialis 2-4 hrs prior or 50mg viagra 1 hr prior. (if needed)
 

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