estradiol

* Testosterone plays an important role in the maintenance of male skeleton. Most studies of testosterone therapy have demonstrated some degree of improvement in BMD * Based on elegant mechanistic studies (discussed below), the current thinking is that both testosterone and estradiol are...

I’ve searched this forum and several others trying to find a situation that matches mine, but I haven’t found anything that really lines up, so I’m posting here hoping someone sees something obvious that I’m missing. I’m a boxer with 15+ years of training. For the last 4 years I’ve been battling...

Curated By Nelson Vergel | ExcelMale.com | Updated June 2026 If you've been on TRT for a while and still deal with flat libido or low motivation - even with testosterone in a solid range - there may be more happening than your T levels alone can explain. One underappreciated piece of that...

https://endo2026.endocrine.org/searchGlobal.asp Background Exogenous estradiol (E2) may be prescribed for transgender females and menopausal women. Automated E2 immunoassays are widely used but bias often exists when compared to mass spectrometry (LC-MS) methods. Lack of assay...

* Dr. Irwin shares his own daily protocols for sexual health, why he believes most older men are leaving capacity on the table, and the surprising data from their own clinic- that more than half the Vyleesi prescriptions they write are off-label for men. They explore why dopamine is dopamine...

Bad science and sensationalized headlines continue to create unnecessary fear surrounding hormone therapy, often overshadowing the clinical benefits for postmenopausal women. Rachel Rubin, MD, and Kelly Casperson, MD, discuss the critical need for medical professionals to look beyond "clickbait"...

Why are so many women still being told estrogen is dangerous? In this episode, Dr Louise Newson is joined by oncologist and author of Estrogen Matters, Dr Avrum Bluming, to explore how fear around hormones took hold and why it persisted for so long. They also revisit the evidence behind the...

Abstract INTRODUCTION AND OBJECTIVES: Testosterone replacement therapy (TRT) is an established treatment for hyposexual desire in postmenopausal women, yet the broader effects of TRT on menopausal symptoms remain uncertain. Our research aims to define optimal testosterone levels for symptomatic...

Take Home Message

Important case study! Listen closely 10:40-40:35 * if you want to have a hard on you need ESTRADIOL! KEY POINTS * aromatase and estradiol are important for men's health * estradiol is an ESSENTIAL METABOLITE of T * I show you on this slide that most of the beneficial actions of...

Dr. Bhasin and Dr. Jasuja most recent paper! Estradiol binding to human serum albumin (HSA) is not a simple linear single-site interaction with a fixed dissociation constant (Kd) as assumed in traditional models (e.g., the Vermeulen/Södergård/Mazer equations for calculating free hormone...

I'd appreciate any advice on my labs. I am on the Crisler protocol. 25 units HCG on Tues Wed, .8cc Test cyp 200mg/ml on Thurs. Low libido wood issues persist. My Labs - pre Thurs testo shot: RBC - 6.58 Hemoglobin - 19.5 Hematocrit - 60.0 Testosterone - 700 Estradiol - 54.1 PSA - 1.9 Thanks...

* “d3-T is a novel, structurally identical form of testosterone where select hydrogen molecules have been substituted with deuterium. This small change creates a significant breakthrough.” * AVA-291 is a “next-generation testosterone designed to retain [testosterone]’s androgen activity while...

* The discovery of kisspeptin neurons in the early part of this century revolutionized our understanding of reproductive regulation. These neurons project to and control GnRH neuronal excitability. More recently, arcuate kisspeptin neurons (KNDy) have been identified as the command neurons...

Transform your approach to menopause care with the latest evidence and expert insights you can use tomorrow. Learn how to move beyond outdated WHI-era fears and confidently prescribe individualized, effective hormonal therapies. We’re joined by urologist and sexual medicine specialist Dr Rachel...

Rachel Rubin, MD

* For eligible customers, personalized menopause and perimenopause treatment plans through Hers may include prescription medication in pill, patch, or cream forms.6 Treatments for eligible customers may include estradiol, a hormone naturally made in the body, to help alleviate symptoms of...

Hot off the press! 25th Annual Fall Scientific Meeting of SMSNA! Grapevine, Texas! Great presentation! 1:29:40-1:43:30 Conclusions

MSACL 2025 Abstract Matthew R Chappell (1), Meghan N Bradley (1), Matthew L Crawford (1), Sven Groesgen (2), Philippe Metz (2), Russell P Grant (1) (1) Center for Esoteric Testing, Labcorp, Burlington NC 27215, (2) Roche Diagnostics GmbH, Mannheim, Germany Abstract INTRODUCTION The...

* Based on our preliminary data, we can conclude that if these values remain above 0.041 for an extended period of time, ED will occur in this group of young men. Figure 1. Тhe E2/T ratio and IEFI result. https://foliamedica.bg/article/143525/list/2/ Abstract Aim This study...

Just putting this out for discussion and comments. There have long been anecdotal suggestions that faster-acting testosterone leads to lower overall levels of estradiol. In particular, it's often claimed in regard to using testosterone propionate versus longer esters such as cypionate. It could...

The guidelines are in and the myths are out. In this episode of the BackTable Podcast, Dr. Suzette Sutherland hosts Dr. Melissa Kaufman and Dr. Giulia Ippolito to discuss the new 2025 AUA/SUFU guidelines on genitourinary syndrome of menopause (GSM). =========== SYNPOSIS The doctors delve...

https://thebms.org.uk/wp-content/uploads/2025/07/24-NEW-BMS-ToolsforClinicians-Measurement-of-serum-estradiol-JULY2025-B.pdf Summary In summary, it is easy to reach for a blood test when HRT is not perceived to be adequately managing symptoms of the menopause transition. Before an...

Abstract Oestradiol (E2), a steroid hormone derived from cholesterol, has long been recognized for its central role in female reproduction and pathobiology of menopause. However, accumulating evidence underscores a critical role for E2 in the regulation of systemic metabolism in both women and...

Hi, Since Maximus TRT+ (oral native Testosterone with enclomiphene) isn't available here, I created my own version using micronized native testosterone powder dissolved in 30g of olive oil, combined with enclomiphene. I've conducted two separate experiments: Baseline / Context: Healthy male...

Hi all..I have come to this forum just to ask a simple question in case anyone can have answers. What would be the reason why a few months before my 33rd birthday which was in May, have I been gaining thigh fat and putting on cellulite all down my thighs like a woman? I ran blood tests and my...

In this episode of the You Are Not Broken podcast, I dive into the new clinical guidelines for Genitourinary Syndrome of Menopause (GSM)—because you deserve facts, not fear. We cover: -- Why education around midlife hormonal changes isn’t optional -- The role of pelvic exams (and how to...

TLDR: I am experiencing wild mood swings and I think it's related to using compounded cream. Can you help me work through it?? I have not posted in a while, so to make up for lost time, I'll give you some diarrhea of the mouth (or keyboard). I'd love to hear some opinions on mood swings. I...

Managing the Testosterone-to-Estradiol Ratio in Men on TRT Introduction Testosterone replacement therapy (TRT) in hypogonadal men often leads to an increase in estradiol (E2) levels due to the aromatization of testosterone. This alters the testosterone-to-estradiol (T:E) ratio, a metric...

In this episode of the Sky Women’s Health Podcast, Dr. Carolyn Moyers, board-certified OB/GYN and Menopause Society Certified Provider, breaks down the newly released 2024 American Urological Association (AUA) Clinical Guideline on Genitourinary Syndrome of Menopause (GSM). What You’ll...

Introduction (00:00) Prof. Celine Bouchard (02:04) Dr. Premitha Damodaran (17:58) Q&A (37:28)