estradiol

ABSTRACT Introduction Vulvovaginal atrophy (VVA) predominantly affects postmenopausal women due to hormonal decline but can also occur in premenopausal women with conditions such as primary ovarian insufficiency or exposure to anti-estrogen medications. Contributing factors include smoking and...

Hi everybody, I thought I would share something a bit interesting for me as I got advanced labs finally. Of note, my E2 which had been very high is now LOW after taking 0.40mg of anastrozole in the past week. From 300 to only 22 (81 pg/ml to 6 pg/ml). Meanwhile, my testosterone is excellent at...

Here's a post on X.com by Danny Roddy discussing the bioenergetic interpretation of high cholesterol, low TSH, low blood estrogen with high testosterone, and high SHBG.

In this talk from the Women’s Health Conversation Summit, hosted by Dr. ‪@vondawright‬ , I’m talking about Genitourinary Syndrome of Menopause (GSM) and why it’s a critical but often overlooked part of women’s health. Hormonal changes during menopause impact more than just hot flashes—they...

* This is the largest study to date characterizing testosterone to estradiol ratios in men presenting for fertility evaluation. We validated the 10/1 ratio that was previously established as the 20th percentile for fertile men. OBJECTIVE To validate the established normal testosterone to...

https://myadlm.org/advocacy-and-outreach/optimal-testing-guide-to-lab-test-utilization/a-f/estradiol-testing-in-men Estradiol in Men: Optimal Testing Recommendations Measurement of estradiol in men (and children) should be performed by a sensitive liquid chromatography-tandem mass...

Hello everybody, Have been doing some reading some reading thru archives about SHBG. Going over my blood results in the past 10 years, I noticed I always had very low SHBG. In my last bloodwork, it was around 14 and that was with a High Free Androgen Index (121.8, ref: 14-95) Testosterone was...

Kelly J. Casperson, MD, Pacific Northwest Urology Specialists, Bellingham, Washington, emphasizes the essential role of vaginal estrogen in treating genitourinary syndrome of menopause (GSM). In this 9-minute talk, she advocates for physicians to integrate vaginal estrogen as a first-line...

Could low-dose masteron be a better alternative to traditional AI medications for controlling estrogen on TRT? This experimental thread documents one user's attempt to manage elevated estradiol levels by adding 10 mg daily of masteron propionate to his testosterone protocol, inspired by...

Speakers: Dr Vikram Talaulikar - What is HRT? Prof Susan Davis - Should HRT include testosterone? Dr Juliet Balfour - Discussing starting HRT with your doctor Dr Jen Gunter - Controversies around HRT Question and Answers from the audience Dr Vikram Talaulikar is an associate specialist...

Hey everyone, I have been on 100mg of Testosterone Cypionate & 750 iu hCG for 8 weeks. My subcutaneous injection schedule is as follows: 20mg Test C - Monday, Wednesday, Friday, Saturday & Sunday 250 iu hCG - Tuesday, Thursday and Sunday I have never had acne this bad before. My back and...

I first started TRT with far too much for far too long 250mg of T Cyp/week. None of my symptoms (crippling fatigue, very low libido etc. improved) Browsing through the internet, I even tried Aromatase inhibitors incase high E conversion was preventing benefits, but that didn't work. When I...

Objectives Postmenopausal females often experience genitourinary symptoms like vulvovaginal dryness due to estrogen decline. Hormone replacement therapy is effective in alleviating vaginal atrophy and genitourinary syndrome in this population. Evaluate local estrogen’s safety and effectiveness...

We’re so excited to have renowned urologist Dr. Rachel Rubin back for another webinar! And this time, we’re talking about sex. She's joined by Alloy community manager Rachel Hughes! If you’re curious about the connection between menopause and sexual health, Dr. Rubin will be explaining the...

The role of testosterone, the androgen receptor, and hypothalamic-pituitary–gonadal axis in depression in ageing Men https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9789012/ Best review on this topic I have seen so far. Might be also very interesting for non-depressed ageing and young men. "In...

As we very well know T s metabolites estradiol and DHT are needed in order to reap full beneficial effects of testosterone. Ts metabolites estradiol and DHT are needed in healthy amounts to experience the full spectrum of testosterones beneficial effects on (cardiovascular health, brain health...

Join us for our 2-year anniversary episode! Host Chase Hendrickson, MD, from Vanderbilt University Medical Center; regular contributor Rich Comi, MD, from Dartmouth Hitchcock Medical Center; and male reproduction expert Mathis Grossman, MD, PhD, FRACP, from the University of Melbourne and Austin...

RR all day! Do you find it difficult to talk to your doctor about your sexual health? Where do you even begin finding the right doctor who will listen? And how can you empower yourself with the knowledge to understand your own sexual anatomy so you can advocate for yourself in the...

Subscribe to our playlist where we will answer every question we can find about vaginal hormones, genitourinary syndrome of menopause (GSM) and how to prevent urinary tract infections for good.

Abstract This review thoroughly explores the multifaceted roles of sexual hormones, emphasizing their impact beyond reproductive functions and underscoring their significant influence on cardiometabolic regulation. It analyzes the broader physiological implications of estrogen, testosterone...

Been on TRT for about 2 years @ 40mg twice per week. Recent bloodwork *(yesterday) shows my estradiol has risen to 54pg/mL (was 40).. At what point will my urologist introduce an AI? Or, is it symptom based? Or, is 54 no big deal?

The thread discusses the modulation of circulating free testosterone fraction during Testosterone Replacement Therapy (TRT) and its relationship with other hormones. Here are the main points from the discussion: Free Testosterone Fraction: The thread emphasizes the importance of the free...

https://www.monash.edu/news/articles/menopause-relief-in-the-spotlight-thanks-to-monash-university-led-studies Improved support and treatment for women experiencing serious physical and/or mental symptoms during menopause is the goal of innovative Monash University research. The cutting-edge...

This is going to upset a lot of women! Two camps at battle here! Stern in her stance she is when is comes to testosterone therapy let alone compounded HRT! Professor Susan Davis AO is a clinical researcher with a profound expertise in the role of sex hormones in women across their...

I am on the old Dr Crisler protocol: I do .25cc of HCG on day 1 and 2, and 0.5cc (100mg) injection of Test cypionate on day 3. It works well for me. The problem is on day 7 my T level is 580 which is OK for me, but my estradiol is 42. Any suggestions greatly appreciated. Many thanks for...

I'm wondering if anyone has experiences or data on the effect of different levels of body fat on aromatization. Right now I'm 18-19% body fat, and I'm wondering if I drop to 10-12% how much that will reduce my E2 if I kept my TRT dose constant. For example, if I drop from 19 to 11% body fat...

I saw this featured on Dr Thomas O'Connor's IG page the other day, and thought it was interesting - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11167061/

I always thought that estrogen helps the liver produce more IGF-1, however, was just researching the connection real quick on google, and it seems like everything states that increasing estrogen actually inhibits the liver from making IGF-1. So a person would actually want lower estrogen levels...

Gentlemen, there is a cure for Low SHBG FINALLY. And, It is tangible unlike the "keto diet and fasting". There is a newly approved drug that could easily more than double our SHBG and for many of us would mean a new life and TRT working. The drug is called Rezdiffra (Resmetirom) manufactured by...