estradiol

Aromatase inhibitors in male: A literature review (2022) Mohsen Korania Abstract Aromatase (CYP19A1) is a monooxygenase from the family of cytochrome P450 that plays role in the androgens to estrogens conversion. Aromatase inhibitors prohibit the aromatase enzyme function. This study reviewed...

TESTOSTERONE AND OSTEOPOROSIS (2023) J.-M. Kaufman Department of Endocrinology, UZ Gent, Gent, Belgium Skeletal effects of testosterone are exerted in part via the androgen receptor and for a substantial part via the estrogen receptors following the aromatization of testosterone to...

Sex Hormones and Cardiovascular Disease in Relation to Menopause (2023) Catherine Kim, MD, MPH, Melissa Wellons, MD, MHS INTRODUCTION Natural menopause is defined as the cessation of menstruation among women who have not undergone a hysterectomy or bilateral oophorectomy. The cessation of...

Do you inject less than 50 mg of T per week? If so, how do you feel? What were/is your lab results before/after you started TRT? I am on 60 mg with high FT, T and E2. I am considering 50 mg, or even less. I'm on Enathate.

Intravaginal Drug Delivery Systems to Treat the Genitourinary Syndrome of Menopause: Towards the Design of Safe and Efficacious Estrogen-loaded Prototypes (2023) Ahmed Abdelgader, Mershen Govender, Pradeep Kumar, Yahya E. Choonara ABSTRACT Estrogens locally delivered to the vagina by tablets...

So this relates to all forums, Reddit, various YouTube videos from doctors, pretty much every internet information source. As of the past few years all the rage and focus is on FT. So much so that certain tests are referred to with derogatory names. “Piss poor”. That’s how important FT is to...

Comparison of Subcutaneous and Intramuscular Estradiol Regimens as part of Gender-Affirming Hormone Therapy (2023) Justine S Herndon, PA-C, Arvind K Maheshwari, MBBS, Todd B Nippoldt, MD, Sara J Carlson, RN CDE, Caroline J Davidge-Pitts, MBBCh, Alice Y Chang, MD Abstract Objective...

I am seeing my endocrinologist tomorrow, curious for initial recommendations as to correct course of action to feel better, low estradiol symptoms.... I had thought of asking about HCG, or estradiol supplementation. Thank you for the help.

Hello All, My name is Steve. I started TRT about 5 months ago and am trying to wrap my head around what my most recent blood testing results are telling me. First of all I am 33, have struggled with my weight for most of my adult life. I would be categorized as obese. I am 6' 2", currently 320...

Hello, I started TRT 11 weeks ago. My protocol is 35 mg of T Enanthate twice a week (Wednesday evening and Sunday morning). Initially I felt quite fine and even libido came earlier than expected (in 4 weeks). My lab results after 6 weeks (a few hours before next injection) were as follows: FT...

Treating where it hurts—a randomized comparative trial of vestibule estradiol for postmenopausal dyspareunia (2023) Martha F. Goetsch, MD, MPH, Bharti Garg, MBBS, MPH, Jen Lillemon, MD, and Amanda L. Clark, MD, MCR, NCMP Abstract Objective: To compare the efficacies of two strengths of...

I had what I believe to be serotonin syndrome, something I wouldn't wish on my own worst enemy, in December of 2021. It took me two months to feel normal, going through brain fog, brain zaps similar to those coming off antidepressant, blurry vision, anhedonia, exhaustion, panic attacks etc. By...

https://www.sciencedirect.com/book/9780128216767/human-gonadotropins#book-description Gonadotropins and steroidogenesis (2022) Estrogens and progestogens The sex steroids are androgen, estrogens, and progestogens. They are all made from the root steroid cholesterol (Fig. 14.1). Cholesterol...

https://etj.bioscientifica.com/view/journals/etj/11/6/ETJ-22-0145.xml Are we having fun yet?

After reading up a ton of literature on Estrogen effects on males, there's really a whole bunch of realisations about how extremely useful it is in male function and consequently how misunderstood and mishandled it is by men or TRT clinics. I'm glad Nelson seems to have a much better...

Struggling to understand this general situation… New doc has started me on enanthate 60mg SQ twice a week. Started monday (today is wed). Also prescribed anastasole 1mg “sometime in between the two doses”. It seems relevant that im 80-90 pounds overweight, carrying it all in belly. Ive read...

This study confirms that D-chiro-inositol raises Testosterone significantly and lowers E2 and Estrone : https://pubmed.ncbi.nlm.nih.gov/34078260/ Why is this not talked about anywhere ? Is there something wrong with the study ? Am I missing something ?

I recently read some discussion by Chris Masterjohn about the effects of biotin on testosterone, b12 and some other levels. Has anyone looked into this? Does it really effect results to a noticeable degree? I've been getting blood work done for 7 years while taking the amount in my multi the...

Hi All, My question is: Given my data below -- would you change anything? Me: 61yo, 5'10", 165lbs, TRT for nearly 2 years. I've titrated up over that time up to current .10mg test cyp SQ daily (last 6 months). Good body composition, good energy, good cognitive function, good libido/sexual...

I seem to have crashed my E2 earlier this month after anastrozole overuse. My E2 was <5.0 on 11/8, but has since bounced back to 30.7 on 11/16. However, I'm still not feeling much relief, specifically from the ed and low libido. I have been taking clomid and HCG since the crashed however (for...

Here is an interesting in vivo study with findings suggesting that lower levels of estrogen in the brain correlate to higher performance in varying forms of memory recall in men. @Cataceous @readalot @Nelson Vergel If a man were to experience brain fog and reduced memory recall while on TRT...

I’ve been struggling with low E2 for the longest time. Started off my TRT 36 mg daily test CYP, 200 IU HCG daily, and 0.0625 mg anastrozole twice per week. Dropped the AI due to low E2 symptoms (mostly achy knees, lethargy, difficulty maintaining/getting erection). Bloodwork showed T = 3100...

This study (Melatonin blocks the activation of estrogen receptor for DNA binding - PubMed) seems to show that melatonin hinders the action of estrogen-bound estrogen receptors. "The present study shows that melatonin prevents, within the first cell cycle, the estradiol-induced growth of...

Hello guys, I'm doing trt for 6 weeks now. 125mg Testosterone enanthate every 5 days. Before trt i was at testosterone levels ~300 (age 23). 185cm, 85kg, %BF ~20-25. Working out hard 3 x week. My diet is very healty, ~2800 kcal. I started trt, because my mood was shit. I was always sleepy...

I’ve come off of TRT, and been off since February. Total t: 534 ng/dl Free t: 62.5 pg/ml Estradiol: less than 15 Does my free T look bad? My whole reason for starting TRT years ago was because of my low free t and very high SHBG. But my estradiol is very low. I have very very low libido. No...

On TRT for just over 4 years. Lately I've been part of a XXXXXXXX group that also has a youtube channel: https://www.youtube.com/c/FoxPowerBasement They are all things TRT, however a very strong theme of the group is that NOBODY needs an AI. EVER. So for the past 6 months or so I have not...

Evaluation of an Anhydrous Permeation‑Enhancing Vehicle for Percutaneous Absorption of Hormones (2022) Guiyun Song · Daniel Banov · Hui Song · Yi Liu · Kendice Ip· August S. Bassani · Benigno C. Valdez Abstract The efficiency and safety of hormone delivery through the skin partly depend on...

To launch the Newson Health Menopause Society, Professor James Simon delivers an in-depth analysis of the 2002 WHI study.

Hei guys I am new here and done my first labtest on 150mg Test propionat per week (42mg Test prop e2d) with hcg 500iu e3d. I think i will higher the dose to 210mg per week with daily administration. So i think my shbg will go up and free and total T also. Because of high aromatase activity i...

Hi guys, I followed the advice of some of the members on here after I was put on 250mg a week and them that shall not be named and dropped my dose down to 118mg a week broken into daily doses on 16mg a day. After 7 weeks my bloods are as follows; SHBG - 25nmol/L Free T - 506 pmol/L (range -...