estradiol

It’s time to reconsider hormone therapy as a treatment for menopause, according to a new analysis of old data (WHI study) published in the Journal of the American Medical Association. This new review suggests that for women in early menopause, the benefits of hormone replacement therapy outweigh...

Hi there I posted a few months ago and took the advice to lower my dosages - thanks to those who advised. Currently on Sustanon, HCG and Anastrazole. This message isn't to have a debate on whether or not AIs are good or bad - we're all different and I understand that @Nelson Vergel doesn't want...

Not sure what thread to put this under— I have gained about 51 pounds since 2018 of mostly abdominal fat. I have noticed at a higher weight, I am not feeling as though my TRT is working long enough. I’m guessing it is getting converted into E2 and/or not hitting the receptor sites as my Free T...

I've finally gotten my results back and here they are (3 mth f/u): TT - 990 (MS) FT - 178 (Dialysis) Estradiol - 44 (LC/MS) Free T3 - 3.2 SHBG - 37 Hematocrit - 54 Hemoglobin - 17.2 LH - <0.2 Reference Range: 1.5-9.3 mIU/mL I'm feeling great and I would not change anything in my protocol...

Hi guys, I find myself outside the US and wanted to check on my estradiol, I can only find an Estradiol ECLIA test here in Italy. I suspect my E2 is gong down. Would this test methodology give me an understanding if my E2 is on the low side, or it would be just better to get back in the US for...

Hi guys, I have couple of questions about my TRT protocol. 1) In my last labs, SHBG came back low (1 unit below normal range). What effect does that have on things like libido, EQ, etc.? Is it necessary to raise it? 2) Unrelated to #1... from time to time my estradiol has been high. Doctor...

About vaginal dryness Vaginal dryness can affect any woman, however, after menopause it is very common, affecting over half of post-menopausal women aged between 51 and 60. This fact sheet will help you to understand vaginal dryness, the symptoms, causes, and treatment, and allow you to...

Studies examining associations of circulating sex steroids with mortality risk in men show inconsistent results for testosterone (T), with limited data for dihydrotestosterone (DHT) and estradiol (E2). We aimed to clarify associations of sex steroids, sex hormone-binding globulin (SHBG), and...

ABSTRACT Objectives Accuracy of estradiol measurements is important but conventional proficiency testing (PT) cannot assess accuracy when possibly non-commutable samples are used and method peer-group means are the targets. Accuracy-based assessment of estradiol measurements is needed...

ABSTRACT Estradiol (E2) has been implicated in sexual functioning in both sexes. E2 levels change distinctively over the menstrual cycle, peaking around ovulation. Data on the short-term effects of fluctuating E2 levels on sexual desire are however sparse and mostly based on observational...

The genitourinary symptoms of menopause encompass a range of changes and challenges that many women may experience as they transition through this natural phase of life. One of the primary manifestations is vaginal dryness, a result of declining estrogen levels that affect the moisture and...

Abstract Stable isotope dilution (SID) methodology coupled with liquid chromatography-tandem mass spectrometry (LC-MS) is rapidly becoming the gold standard for measuring estrogens in serum and plasma due to improved specificity, high accuracy, and the ability to conduct a more comprehensive...

Dr. James Simon discusses the lack of attention given to postmenopausal vulva and vagina health and the evidence-based approach to addressing this issue. He explains the clinical manifestations of hormonal-mediated vestibular denia (VVS) and genital urinary syndrome of menopause (GSM)...

Hello all, I was previously on 90 mg/week, divided in 3 weekly doses of 30 mg, M-W-F, IM on the deltoids. After 6 weeks on this protocol, the labs indicated: Total T: 1044 ng/dL Free T: 19.52 ng/dl Estradiol sensitive: 34 pg/mL SHBG: 36 nmol/L However, I had the following sides effects: -...

https://podcasts.apple.com/us/podcast/229-sex-med-advocate-and-isswsh-president-sue-goldstein/id1495710329?i=1000628147862 Sex Med Advocate and ISSWSH President - Sue Goldstein Sue Goldstein is an AASECT certified sexuality educator and certified clinical research coordinator. She serves as...

https://cms.megaphone.fm/channel/BTL2162345307?selected=BTL3168772379 This week on BackTable Urology, Dr. Suzette Sutherland and Dr. Rachel Rubin discuss the diagnosis and treatment of genitourinary syndrome of menopause (GSM) with vaginal estrogen.

In this video, urologists Dr. Rachel Rubin and Dr. Catherine Kloss discuss the topic of Genitourinary Syndrome of Menopause (GSM) or vaginal atrophy. They provide information on the symptoms, treatment options, safety, and the importance of using hormonal therapy for vaginal health. They also...

Abstract Objectives: In laboratory medicine, external quality assessment (EQA) schemes have become versatile tools for detecting analytical flaws. However, EQA schemes are lacking for pediatric sex steroid levels. We aimed to investigate the suitability of different estradiol and testosterone...

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9016457/ "These analyses were not prespecified and need confirmation in additional studies of other datasets. Our models were modestly predictive, with r-squared values ranging from 0.16 for HDL cholesterol to 0.27 for vBMD, indicating that there...

I've been on TRT for about 10 years. Every time I read the benefits I realize I've never really experienced them. I wondered if I'm on the right dose. It never helped with depression so I take Wellbutrin. I'm 65 yrs old. I was on 0.7 ml but I started to have some problems. I didn't feel great...

Hi there. I’ve been in trt for a year using gels two pumps daily. Also was using hcg twice a week. My challenge is that my E2 levels are really high compared to where I started and although they are not in the clinical danger zone I do find I’m having some issues ie no erections, feeling...

Hey there! I've been on TRT for a while due to secondary hypogonadism. Due to moving / no job, I was off TRT for 2-3 years and my levels dropped to "normal" which for me is <200 total T. Started seeing a new PCP last year who ran 2 morning T tests, both came back low, so he started me on...

Hello, I am 35 175lbs 5’11 and have been on TRT for 2 years. I have been trying to find my sweet spot and get dialed in the majority of the 2 years. I work out 6 days a week and eat very healthy etc…My current issues are: Back acne Oily face Low libido Testes and penis always feel cold and have...

Local estrogen therapy (LET) is the standard treatment for urogenital symptoms. Various formulations and molecules have been used with similar results. Low-dose LET is preferred for minimal systemic absorption. Patient preference is crucial, but dissatisfaction exists. Breast cancer survivors...

The pharmacological regimen increased E2 levels for more than 24 hours, affecting the HPG axis, LH, FSH, P4, TST, DHT, SHBG, and IGF-1. While E2 had similar effects to longer-term treatments, SHBG levels did not increase. TST and DHT changes could confound the effects of E2. These hormones have...

Estradiol: 64.2. (since this result, I started taking arimidex .5 mg (1/2. tablet) twice per week Testosterone total: 1,190 Testosterone free: 25.6 What is the best range for best results? I know the estrogen was too high...

I know everyone is different, but I would like to hear what you have found best for inj frequency, My SHBG is mid range at 45, E2 runs a bit high at 60, HCT and HGB has been a problem for me, last blood work it was 57 and 19 so I did go donate, in the past I have had issues when i donated 3...

When Intimacy hurts...Genitourinary Syndrome of Menopause, Vaginismus, and Vulvodynia // dyspareunia, or pain with intercourse, is a very common medical condition that affects millions of women. In this video, I break down three of the common reasons why there is pain with intercourse. The three...

https://www.issm.info/meetings/issm-podcasts/issm-podcast-season-1-episode-7 In episode 7 of the ISSM Podcast, Dr. Tami Rowen talks about the impact of female contraceptives (birth control) on one’s sexuality. Listen to this informative talk, hosted by Shelly Varod (Israel), certified sex...