trt

  1. madman

    Azoospermia on TRT? hCG vs Clomid for Fertility—Why Sperm Recovery May Not Depend on FSH

    Abstract INTRODUCTION AND OBJECTIVES: To evaluate FSH recovery rates and sperm production in men with testosterone therapy (TTh)-induced azoospermia treated with hCG alone versus hCG combined with clomiphene citrate, focusing on men with severely suppressed baseline FSH. METHODS...
  2. madman

    Why Normal Testosterone Levels May Still Cause Symptoms: The Hidden Role of CAG Repeat Length in TRT

    Abstract INTRODUCTION AND OBJECTIVES: The preferred treatment for hypogonadism, testosterone replacement therapy (TRT), has a varying efficacy that is currently not understood. This observation may be explained by polymorphism of the androgen receptor (AR), a ligand-binding transcription factor...
  3. madman

    Once-Weekly hCG Helps Preserve Fertility in Men on Testosterone Therapy (Largest Study Yet)

    Abstract INTRODUCTION AND OBJECTIVES: Testosterone therapy (TTh) is known to suppress spermatogenesis, but combination TTh with human chorionic gonadotropin (hCG) has been shown to maintain spermatogenesis in a small 26-patient case series. That study did not account for prior fertility (or...
  4. madman

    Dr Jeff Foster - Director of Men’s Health at Voy/Manual (UK)

    https://www.joinvoy.com/experts/dr-jeff-foster https://www.h3health.co.uk/ https://www.joinvoy.com/trt https://www.excelmale.com/threads/british-society-for-sexual-medicine-guidelines-on-male-adult-td.27188/...
  5. M

    Crashed E2 from eq

    Hello guys so recently I got my estrogen sensitive test back and it was 5 Side effect been sleep is trash no amount supplements such as melatonin or magnesium helping at all brain fog feeling tired over all And tbh I had gotten my estrogen back up and I noticed those side effects never went...
  6. madman

    Comparative review of the PK and PD of testosterone therapies in T2DM

  7. P

    Considering setting up an AI Agent for trt research and looking for input

    Been thinking about this for a while and might actually go through with the project. As someone in the tech field who has been interested in health and research for decades I’ve started to consider the combing the two now that tech has reached it’s current state(and only getting better). These...
  8. B

    Seeking Advice. Off Test Six Months. Test Still Low.

    Just done my 6 month blood test and my test remains unchanged since December 2025. Very low!!!! These are my results: Oestradiol <19 (pmol/L) Testosterone (total) 4.6 (nmol/L) Free Testosterone 0.09 (nmol/L) FSH 2.6 (IU/L) LH 1.3 (IU/L) SHBG 28.6 (nmol/L) For context, my pre-TRT baseline...
  9. madman

    Controversies with Testosterone Replacement Therapy

    Dr. Khera of course! * if you prescribe testosterone there are five controversies you have to know about! Mohit Khera, MD, MBA, MPH Professor of Urology F. Brantley Scott Chair in Urology Director, Laboratory for Andrology Research Faculty Group Practice Medical Director Baylor College...
  10. madman

    Experts react to FDA’s potential pathway for TRT label expansion

    Following the FDA’s announcement on a potential pathway to expand testosterone replacement therapy (TRT) labeling,1 leading experts in men’s health shared their perspectives on what this development could mean for patients and clinical practice.
  11. madman

    FDA Signals Potential Expansion of Testosterone Therapy to Treat Low Libido in Idiopathic Hypogonadism

    https://www.ajmc.com/view/fda-signals-potential-expansion-of-testosterone-therapy-to-treat-low-libido-in-idiopathic-hypogonadism https://www.fda.gov/news-events/press-announcements/fda-takes-step-forward-testosterone-therapy-men The U.S. Food and Drug Administration today is taking an...
  12. N

    Just found out I’m MTHFR

    Been on trt for 15 years. Results have been subpar, havnt really felt that great even with good testosterone levels and if I tried to get the number higher into the high end of normal I would feel real shitty within days. I now believe this was because of the double MTHFR gene mutation. I’ve...
  13. madman

    Gonadal recovery in men with prolactinomas on cabergoline

  14. madman

    Erectile Dysfunction: The TRUTH About Cialis, Viagra & Testosterone

    * Hormones are only one component of a complex system involving vascular function, neurologic signaling, metabolic health, medications, and psychosocial factors. Listen closely! 5:00 ED vs Low Testosterone: Why They’re Not the Same In Part 2 of this conversation on men’s health and...
  15. madman

    Erectile Dysfunction Isn’t Just About Sex — Here’s What It’s Really Telling You

    In this episode of Hormones and Hope, Dr. Chhaya Makhija begins a two-part series on men’s health and erectile dysfunction with urologist and sexual medicine specialist Dr. Katherine Klos. Key Takeaways: * What are the medical causes of erectile dysfunction? * Can erectile dysfunction...
  16. madman

    The $49 Test That Saves Lives: Dr. Mohit Khera’s Warning for Men Over 40

    You would mean the $49 test which includes the most critical blood marker free testosterone tested using the most accurate assay the gold standard Equilibrium Dialysis! https://www.discountedlabs.com/testosterone-free-dialysis-and-total-ms I agree Dr. Khera is a true powerhouse in the...
  17. C

    TRT which causes pelvic floor pain (CPPS)

    6'2", 246 lbs (111kg) male (with a decent frame). I have a 3mm L4-S1 protrusion, but my main issue is severe anal/perineal burning (CPPS) that is directly triggered by TRT (also have back pain). I’ve tried various esters (test p/e/c/nebido) and injection frequencies (daily/eod/weekly/biweekly)...
  18. I

    New man in trt

    Ciao, ho iniziato la terapia sostitutiva con testosterone (TRT). Ho iniziato con il Testosterone Undecanoato per via orale, assumendo due dosi da 40 mg al giorno. Inizialmente mi sentivo molto meglio: motivazione, erezione, libido, tutto perfetto... poi ho iniziato ad avere forti dolori allo...
  19. madman

    Spermatogenesis Recovery after Testosterone Use

    We do it big here!
  20. L

    Need some input / direction please <> Labs Attached

    Good afternoon! 53YO, been on TRT for almost 10 years. I switched to a local provider for my TRT. My E2 has spiked and I'm dealing with the usual ED, zero libido, no focus and indifferent on everything (again). But this round of ED is so much worse and I'm hoping an AI would bring the E2 down...
  21. madman

    Etiology of testosterone deficiency after radical prostatectomy

    Abstract Introduction Testosterone deficiency (TD) may occur after radical prostatectomy (RP). Guidance on prevalence, mechanisms, and testosterone-replacement therapy (TRT) safety remains limited. Objective To summarize contemporary evidence on the etiology of post-RP TD. Methods A...
  22. S

    Dr Rand just put out a new video on FB with ideal trough levels

    Dr Rand just put out a new video on FB with ideal trough levels. He claims that we have known since the 50s that test levels using exogenous testosterone are not the same as those with endogenous production. He said the IDEAL tough level on a once weekly injection is total T 800ng/dl and free...
  23. S

    I have to switch from TRT to HCG monotherapy every 6 to 9 months to get my libido back. Does anyone know what is happening and how I can avoid this?

    As the title says... after years and years I have figured out this vicious cycle and I do not understand it. Every 6 to 9 months my libido just tanks and I need to go on HCG monotherapy for 3/4 weeks at 1000iu MWF. My sex drive begins to build by the end of week 1 and then comes raging back...
  24. A

    Wondering what to do. 23m

    I am 23m 6’2 275 Recent blood tests have shown a total Test level of 260ngdl My doctors are very reluctant to give me a requisition for FH and LH, which would determine the cause of this borderline hypogonadism level. My diet and training is extremely locked in. 21-2300 cal with 200+ protein...
  25. T

    Sleep, HCG and elevated H&H

    Having issues with sleep and elevated H&H that came about 3 or 4 months after starting injections. Never had issues with sleep before TRT. On the following trough results, i was doing 40mg e3d IM Total T 631 Free T (direct) 23.5 (9.3-26.5) E2 sensitive 24 SHBG 10.4 HCT 52.1 HGB 17.9 Have since...
  26. J

    My TRT is at Risk due to shortage

    Been on TRT since 2015 when my Urologist put on TRT. My testosterone was 77. I was doing well on it but unfortunately my health insurance stopped paying for it because my Blood Work was NORMAL --- 700-800. My doctor appealed their decision but it was denied. I decided to use Cyp on my own...
  27. O

    Ideal protocol for trialing TRT?

    When looking through various TRT forums, I've noticed that the idea of performing a trial period for TRT is often looked down upon. The pervading notion is that it's a simply a lifelong commitment. I understand testosterone's potential for natural suppression, and I assume that's the reason for...
  28. C

    Post TRT - Libido is DEAD :(

    I was on TRT for 3 years and stopped 7 weeks ago. Since stopping, my libido has been completely dead. Symptoms: no wet dreams no morning erections zero libido zero interest in sex I can still get an erection if I want energy level is good Recovery meds: Clomid for 5 weeks past 2 weeks...
  29. madman

    Testosterone Replacement Therapy & Prostate Cancer

    Stop wasting your time on those kiddie forums, Nelson's house is where it's at! Dr. Omer Raheem Agenda Conclusions
  30. madman

    How to treat obesity and hypogonadism; The male hormone reset

    Professor Michael Zitzmann Testosterone Deficiency (TD). and its Effects https://www.excelmale.com/threads/the-male-hormone-reset-how-glp-1ras-lifestyle-and-testosterone-transform-obesity-linked-problems.33386/
  31. J

    Week one on kyzatrex: the “convenience” part is real

    Quick update since i posted last week. i’m about a week into kyzatrex (oral tu) and honestly the biggest change so far isn’t some crazy boost… it’s just that i’m not thinking about needles at all. i travel a lot and not having to pack pins / deal with airport stuff already feels like a win. As...
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